Results 191 to 200 of about 139,619 (346)

Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR

Advanced Science, EarlyView.
The tumor microenvironment supports colorectal cancer (CRC) progression by maintaining cancer stem cells (CSCs) through progastrin (PG). This study identifies Protein Zero‐Related protein (PZR) as an essential receptor for PG activity, promoting CSC‐like signaling via SHP2/SRC/β‐catenin.
Julie Nguyen, Marie Lafitte, Maud Barbery, Kevin Espie, Maya Jeitany, Romain Larive, Jihane Vitre, Conception Paul, Yvan Boublik, Elise Fourgous, Valérie Simon, Audrey Sirvent, Madeline Neiveyans, Steeve Thirard, Lucile Bansard, Morgan Maillard, Nathalie Coutry, Jacques Colinge, Philippe Jay, Pierre Martineau, Michael Hahne, Julie Pannequin, Serge Roche   +22 more
wiley   +1 more source

Interaction between the Adhesion Receptor, CD44, and the Oncogene Product, p185 , Promotes Human Ovarian Tumor Cell Activation [PDF]

, 1997
Lilly Bourguignon, Hongbo Zhu, Arthur J. Chu, Naoko Iida, Lisha Zhang, Mien‐Chie Hung   +5 more
openalex   +1 more source

Forms and functions of CD44

Immunology, 1998
G Borland, James A. Ross, K Guy
openaire   +3 more sources

Novel Quaternary Ammonium Salt‐Linked STING Agonist Antibody‐Drug Conjugate: Synergistic Activation of Tumor Immunity with Mitigated Off‐Target Toxicity

Advanced Science, EarlyView.
Novel quaternary ammonium salt‐linked STING agonist ADC demonstrates high potency, stability, enhanced solubility, and reduced off‐target toxicity, potently activating the STING pathway in the tumor microenvironment through the synergistic action of the Fab and Fc regions of antibodies (activity switch‐on) while exhibiting ≈20 fold lower activity in ...
Yu Long, Borui Tang, Fei Xie, Lianqi Liu, Yangyihua Zhou, Jingwen Dong, Jianfeng Wang, Cuicui Sun, Yuting Wang, Ruoqi Li, Na Zhang, Liping Li, Longlong Luo, Junhai Xiao, Wu Zhong, Dian Xiao, Hongbin Deng, Xinbo Zhou   +17 more
wiley   +1 more source

Regulated clustering of variant CD44 proteins increases their hyaluronate binding capacity. [PDF]

, 1996
Jonathan P. Sleeman, W. Rudy, Martin Hofmann‐Apitius, Jürgen Moll, Peter Herrlich, Helmut Ponta   +5 more
openalex   +1 more source

Dual‐Targeted Nanovesicles Induced Cancer Stem‐Like Cell Differentiation to Sensitize Hepatocellular Carcinoma Radiotherapy

Advanced Science, EarlyView.
The existence of Pin1 and Notch1 crosstalk is identified and verified in HCC, and the crucial function of this crosstalk in sustaining the aggressive phenotypes of CSCs and radioresistance. A biomimetic nanovesicle is now developed to block the crosstalk between Pin1 and Notch1 for inducing CSCs differentiation and sensitizing HCC radiotherapy ...
Hongmei Cao, Qian Wang, Yanan Niu, Shuxiang Wang, Haixue Jia, Dianyu Wang, Jinjian Liu, Wei Yuan, Lijun Yang, Jianfeng Liu   +9 more
wiley   +1 more source

The Cell Adhesion Molecule, GP116, Is a New CD44 Variant (ex14/v10) Involved in Hyaluronic Acid Binding and Endothelial Cell Proliferation [PDF]

, 1996
Vinata B. Lokeshwar, Naoko Iida, Lilly Bourguignon   +2 more
openalex   +1 more source

Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C

Advanced Science, EarlyView.
The release of COL6A3 by fibroblasts is sensed by the CD44 receptor on melanocytes, activating glutathione (GSH) metabolism and increasing melanocyte survival during skin organoid culture. SEMA3C released by bulge cells binds to the NRP1 receptor on melanocytes, regulating microtubule stability and promoting melanocyte recruitment and function during ...
Tingting Li, Xinzhu Li, Xiao Xiang, Jundong Huang, Xinyu Shen, Mengyue Wang, Jingwei Jiang, Shiwen Shao, Zeming Li, Tian Xie, Deming Liu, Yiping Zhao, Rui Ma, Wenyu Wu, Wei Shi, Cheng‐Ming Chuong, Ji Li, Mingxing Lei   +17 more
wiley   +1 more source

Universal Fab-Fc masked cytokine prodrug platform: αPD-L1/IL-15 prodrug activates CD44⁺ CD8⁺ T cells in tumor-draining lymph nodes to enhance antitumor immunity. [PDF]

J Immunother Cancer
Song L, Qi G, Shi W, Zeng Q, Qin Y, Wang Z, Li W, Song Z, Zhang A, Lu H.   +9 more
europepmc   +1 more source

Acute lung injury fibroblast migration and invasion of a fibrin matrix is mediated by CD44. [PDF]

, 1996
K Svee, James G. White, Pierre Vaillant, José Jessurun, Urvashi V. Roongta, M Krumwiede, Donald E. Johnson, Craig A. Henke   +7 more
openalex   +1 more source