Diverse Roles for Hyaluronan and Hyaluronan Receptors in the Developing and Adult Nervous System [PDF]
International Journal of Molecular Sciences, 2020 Hyaluronic acid (HA) plays a vital role in the extracellular matrix of neural tissues. Originally thought to hydrate tissues and provide mechanical support, it is now clear that HA is also a complex signaling molecule that can regulate cell processes in the developing and adult nervous systems.
Alec Peters +2 more
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Hyaluronan Receptors as Mediators and Modulators of the Tumor Microenvironment. [PDF]
Adv Healthc Mater, 2023 AbstractThe tumor microenvironment (TME) is a dynamic and complex matter shaped by heterogenous cancer and cancer‐associated cells present at the tumor site. Hyaluronan (HA) is a major TME component that plays pro‐tumorigenic and carcinogenic functions.
Carvalho AM, Reis RL, Pashkuleva I.
europepmc +4 more sources
In Vivo Molecular Optical Coherence Tomography of Lymphatic Vessel Endothelial Hyaluronan Receptors [PDF]
Scientific Reports, 2017 Optical Coherence Tomography (OCT) imaging of living subjects offers increased depth of penetration while maintaining high spatial resolution when compared to other optical microscopy techniques.
Peng Si +7 more
doaj +2 more sources
Matrix: a complex amalgam of structures and functions in tumor microenvironment [PDF]
FEBS Open BioCancer cells surrounded by a rich diversity of nonmalignant cell types are collectively embedded in the matrix, which is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties.
Spyros S. Skandalis +3 more
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Cells, 2021 Entry to the afferent lymphatics marks the first committed step for immune cell migration from tissues to draining lymph nodes both for the generation of immune responses and for timely resolution of tissue inflammation.
Louise A Johnson +2 more
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Immunological functions of hyaluronan and its receptors in the lymphatics
Immunological Reviews, 2009 Summary: The lymphatic system is best known for draining interstitial fluid from the tissues and returning it to the blood circulation. However, the lymphatic system also provides the means for immune surveillance in the immune system, acting as conduits that convey soluble antigens and antigen‐presenting cells from the tissues to the lymph nodes ...
David G Jackson
exaly +3 more sources
Effective Cryopreservation of Post Mortem-Collected Roe Deer Gametes by Evaluation of Post-Thaw Oocyte and Sperm Characteristics and In Vitro Fertilization [PDF]
AnimalsThe aim was to evaluate the effectiveness of semen cryopreservation and oocyte vitrification in roe deer as a potential method of gamete preservation for endangered deer species.
Anna Justyna Korzekwa +5 more
doaj +2 more sources
Role of hyaluronan in endometrial receptivity: key insights for implantation and reproductive success [PDF]
Reproductive Biology and EndocrinologyInfertility affects millions worldwide, and implantation failure remains a critical barrier in assisted reproduction. Endometrial receptivity, a fundamental prerequisite for successful implantation, involves precise regulation of extracellular matrix ...
Eva Krivakova +6 more
doaj +2 more sources
Frontiers in Immunology, 2015 The glycosaminoglycan hyaluronan (HA), a major component of extracellular matrices (ECMs), and cell surface receptors of HA have been proposed to have pivotal roles in cell proliferation, migration, and invasion, which are necessary for inflammation and ...
Suniti Misra +2 more
exaly +3 more sources
Signaling Properties of Hyaluronan Receptors [PDF]
Journal of Biological Chemistry, 2002 Eva A Turley +2 more
exaly +3 more sources