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Hyaluronan: Metabolism and Function
Biomolecules, 2020 As a major polysaccharide component of the extracellular matrix, hyaluronan plays essential roles in the organization of tissue architecture and the regulation of cellular functions, such as cell proliferation and migration, through interactions with ...
Takashi Kobayashi +2 more
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Cells, 2020 Hyaluronan is an extracellular matrix component that absorbs water in tissues and engages cell surface receptors, like Cluster of Differentiation 44 (CD44), to promote cellular growth and movement.
Zhengcheng He +3 more
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Chain Gangs: New Aspects of Hyaluronan Metabolism [PDF]
Biochemistry Research International, 2012 Hyaluronan is a matrix polymer prominent in tissues undergoing rapid growth, development, and repair, in embryology and during malignant progression. It reaches 107 Daltons in size but also exists in fragmented forms with size-specific actions.
Michael Erickson, Robert Stern
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Lipid raft-mediated regulation of hyaluronan-CD44 interactions in inflammation and cancer
Frontiers in Immunology, 2015 Hyaluronan is a major component of the extracellular matrix and plays pivotal roles in inflammation and cancer. Hyaluronan oligomers are frequently found in these pathological conditions, in which they exert their effects via association with the ...
Toshiyuki eMurai
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SPERM SELECTION WITH HYALURONAN AND BLASTOCYST DEVELOPMENT AFTER ICSI
Zdravniški Vestnik, 2018 Background. Selection of mature sperm for intracytoplasmic sperm injection (ICSI) has recently been made possible by hyaluronan, a naturally occurring substance found in the cumulus cells.
Lili Bačer Kermavner +4 more
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Hyaluronan Regulates Cell Behavior: A Potential Niche Matrix for Stem Cells
Biochemistry Research International, 2012 Hyaluronan is a linear glycosaminoglycan that has received special attention in the last few decades due to its extraordinary physiological functions.
Mairim Alexandra Solis +5 more
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Localization of CD44 (Hyaluronan Receptor) and Hyaluronan in Rat Mandibular Condyle [PDF]
Journal of Histochemistry & Cytochemistry, 2005 CD44 is a multifunctional adhesion molecule that binds to hyaluronan (HA), type I collagen, and fibronectin. We investigated localization of CD44 and HA in mandibular condylar cartilage compared with the growth plate and the articular cartilage, to clarify the characteristics of chondrocytes.
Hiroaki, Nakamura +4 more
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Knock-down of CD44 regulates endothelial cell differentiation via NFκB-mediated chemokine production. [PDF]
PLoS ONE, 2014 A striking feature of microvascular endothelial cells is their capacity to fuse and differentiate into tubular structures when grown in three-dimensional (3D) extracellular matrices, in collagen or Matrigel, mimicking the in vivo blood vessel formation ...
Berit Olofsson +2 more
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Cell Adhesion & Migration, 2023 The sensitivity to cold plasma is specific to tumor cells while leaving normal tissue cells unaffected. This is the desired challenge in cancer therapy. Therefore, the focus of this work was a comparative study concerning the plasma sensitivity of dermal
Anna-Christin Golz +5 more
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The hyaluronan receptor (CD44) participates in the uptake and degradation of hyaluronan. [PDF]
The Journal of cell biology, 1992 The hyaluronan receptor belongs to the polymorphic family of CD44 glycoproteins, which have been implicated in a variety of cellular functions including adhesion to hyaluronan and collagen, the binding of lymphocytes to high endothelial cells during extravasation, and conferring metastatic potential to carcinoma cells.
M, Culty, H A, Nguyen, C B, Underhill
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