Results 21 to 30 of about 27,596 (198)
Biomedicines, 2022 Background: Hyaluronan (HA), a component of the extracellular matrix, is frequently increased under pathological conditions including cancer. Not only stroma cells but also cancer cells themselves synthesize HA, and the interaction of HA with its cognate
Leticia Oliveira-Ferrer +5 more
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Identification of the Hyaluronan Receptor for Endocytosis (HARE) [PDF]
Journal of Biological Chemistry, 2000 Rat liver sinusoidal endothelial cells (LECs) express two hyaluronan (HA) receptors, of 175 and 300 kDa, responsible for the endocytic clearance of HA. We have characterized eight monoclonal antibodies (mAbs) raised against the 175-kDa HA receptor partially purified from rat LECs. These mAbs also cross-react with the 300-kDa HA receptor. The 175-kDa HA
B, Zhou +3 more
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Anticancer Therapeutics: Targeting Macromolecules and Nanocarriers to Hyaluronan or CD44, a Hyaluronan Receptor [PDF]
Molecular Pharmaceutics, 2008 The complex system involved in the synthesis, degradation and binding of the high molecular weight glycosaminoglycan hyaluronic acid (hyaluronan or HA) provides a variety of structures that can be exploited for targeted cancer therapy. In many cancers of epithelial origin there is an upregulation of CD44, a receptor that binds HA.
Virginia M, Platt, Francis C, Szoka
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Chain Gangs: New Aspects of Hyaluronan Metabolism
Biochemistry Research International, 2012 Hyaluronan is a matrix polymer prominent in tissues undergoing rapid growth, development, and repair, in embryology and during malignant progression. It reaches 107 Daltons in size but also exists in fragmented forms with size-specific actions.
Michael Erickson, Robert Stern
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The molecular regulation of oligodendrocyte development and CNS myelination by ECM proteins
Frontiers in Cell and Developmental Biology, 2022 Oligodendrocytes are myelin-forming cells in the central nervous system (CNS). The development of oligodendrocytes is regulated by a large number of molecules, including extracellular matrix (ECM) proteins that are relatively less characterized. Here, we
Momona Yamada +3 more
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The Content and Size of Hyaluronan in Biological Fluids and Tissues
Frontiers in Immunology, 2015 Hyaluronan is a simple repeating disaccharide polymer, synthesized at the cell surface by integral membrane synthases. The repeating sequence is perfectly homogeneous, and is the same in all vertebrate tissues and fluids.
Mary K. Cowman +4 more
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SPERM SELECTION WITH HYALURONAN AND BLASTOCYST DEVELOPMENT AFTER ICSI
Zdravniški Vestnik, 2018 Background. Selection of mature sperm for intracytoplasmic sperm injection (ICSI) has recently been made possible by hyaluronan, a naturally occurring substance found in the cumulus cells.
Lili Bačer Kermavner +4 more
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Dissecting the Dual Nature of Hyaluronan in the Tumor Microenvironment
Frontiers in Immunology, 2019 Hyaluronan (HA) is a glycosaminoglycan with a simple structure but diverse and often opposing functions. The biological activities of this polysaccharide depend on its molecular weight and the identity of interacting receptors.
Muhan Liu +3 more
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Hyaluronan Regulates Cell Behavior: A Potential Niche Matrix for Stem Cells
Biochemistry Research International, 2012 Hyaluronan is a linear glycosaminoglycan that has received special attention in the last few decades due to its extraordinary physiological functions.
Mairim Alexandra Solis +5 more
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Cell Death Discovery, 2021 The extracellular matrix plays a key role in cancer progression. Hyaluronan, the main glycosaminoglycan of the extracellular matrix, has been related to several tumor processes. Hyaluronan acts through the interaction with cell membrane receptors as CD44
Matías Arturo Pibuel +6 more
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