Results 31 to 40 of about 28,152 (259)

The molecular regulation of oligodendrocyte development and CNS myelination by ECM proteins

Frontiers in Cell and Developmental Biology, 2022
Oligodendrocytes are myelin-forming cells in the central nervous system (CNS). The development of oligodendrocytes is regulated by a large number of molecules, including extracellular matrix (ECM) proteins that are relatively less characterized. Here, we
Momona Yamada, Miho Iwase, Binri Sasaki, Nobuharu Suzuki   +3 more
doaj   +1 more source

The Content and Size of Hyaluronan in Biological Fluids and Tissues

Frontiers in Immunology, 2015
Hyaluronan is a simple repeating disaccharide polymer, synthesized at the cell surface by integral membrane synthases. The repeating sequence is perfectly homogeneous, and is the same in all vertebrate tissues and fluids.
Mary K. Cowman, Hong-Gee eLee, Kathryn L. Schwertfeger, James B. McCarthy, Eva A. Turley   +4 more
doaj   +1 more source

Dissecting the Dual Nature of Hyaluronan in the Tumor Microenvironment

Frontiers in Immunology, 2019
Hyaluronan (HA) is a glycosaminoglycan with a simple structure but diverse and often opposing functions. The biological activities of this polysaccharide depend on its molecular weight and the identity of interacting receptors.
Muhan Liu, Cornelia Tolg, Eva Turley, Eva Turley   +3 more
doaj   +1 more source

Natriuretic peptide receptors regulate cytoprotective effects in an ex vivo human 3D/bioreactor model [PDF]

, 2013
IntroductionThe present study examined the effect of C-type natriuretic peptide (CNP) and biomechanical signals on anabolic and catabolic activities in chondrocyte/agarose constructs.MethodsNatriuretic peptide (Npr) 2 and 3 expression were compared in ...
Salter, Donald M, Salter, Donald M., Ramachandran, Manoj, Adrian J Hobbs, Hobbs, Adrian J., Ramachandran, M, Moyes, AJ, Amie J Moyes, Peake, Nicholas, Bader, Dan L, Bader, DL, Chowdhury, Tina T., Donald M Salter, Pramod Achan, Bader, Dan L., Peake, N, Su, N, Achan, P, Hobbs, AJ, Salter, DM, Nyan Su, Achan, Pramod, Nicholas Peake, Chowdhury, TT, Moyes, Amie J., Dan L Bader, Tina T Chowdhury, Su, Nyan, Chowdhury, Tina T, Hobbs, Adrian J, Moyes, Amie J, Manoj Ramachandran   +31 more
core   +1 more source

Antitumor effect of 4MU on glioblastoma cells is mediated by senescence induction and CD44, RHAMM and p-ERK modulation

Cell Death Discovery, 2021
The extracellular matrix plays a key role in cancer progression. Hyaluronan, the main glycosaminoglycan of the extracellular matrix, has been related to several tumor processes. Hyaluronan acts through the interaction with cell membrane receptors as CD44
Matías Arturo Pibuel, Daniela Poodts, Mariángeles Díaz, Yamila Azul Molinari, Paula Gabriela Franco, Silvia Elvira Hajos, Silvina Laura Lompardía   +6 more
doaj   +1 more source

Hyaluronan goes to great length

Cell Stress, 2020
Hyaluronan is a major non-protein component of extracellular matrix that affects biomechanical properties of tissues and interacts with cell receptors.
Vera Gorbunova, Masaki Takasugi, Andrei Seluanov   +2 more
doaj   +1 more source

GBS hyaluronidase mediates immune suppression in a TLR2/4- and IL-10-dependent manner during pregnancy-associated infection

mBio, 2023
Bacterial infections remain a significant cause of adverse pregnancy outcomes. Ascending infection of group B streptococcus (GBS) or Streptococcus agalactiae from the lower genital tract to the amniotic cavity leads to fetal injury, preterm births, or ...
Michelle Coleman, Austyn Orvis, Alyssa Brokaw, Anna Furuta, Kavita Sharma, Phoenicia Quach, Avneet Bhullar, Rhea Sanghavi, Shayla Nguyen, Erin Sweeney, Ravin Seepersaud, Blair Armistead, Kristina M. Adams Waldorf, Lakshmi Rajagopal   +13 more
doaj   +1 more source

Versican—A Critical Extracellular Matrix Regulator of Immunity and Inflammation

Frontiers in Immunology, 2020
The extracellular matrix (ECM) proteoglycan, versican increases along with other ECM versican binding molecules such as hyaluronan, tumor necrosis factor stimulated gene-6 (TSG-6), and inter alpha trypsin inhibitor (IαI) during inflammation in a number ...
Thomas N. Wight, Inkyung Kang, Stephen P. Evanko, Ingrid A. Harten, Mary Y. Chang, Oliver M. T. Pearce, Carys E. Allen, Charles W. Frevert   +7 more
doaj   +1 more source

Ligand Binding and Signaling of HARE/Stabilin-2

Biomolecules, 2019
The Stabilin receptors are a two-member family in the type H class of scavenger receptors. These dynamic receptors bind and internalize multiple ligands from the cell surface for the purpose of clearing extracellular material including some synthetic ...
Edward N. Harris, Fatima Cabral
doaj   +1 more source

Hyaluronan in the Cancer Cells Microenvironment [PDF]

, 2023
The presence of the glycosaminoglycan hyaluronan in the extracellular matrix of tissues is the result of the cooperative synthesis of several resident cells, that is, macrophages and tumor and stromal cells.
Manuela Viola, Evgenia Karousou, Alberto Passi, Paola Moretto, Arianna Parnigoni, Davide Vigetti   +5 more
core   +1 more source