Results 51 to 60 of about 27,596 (198)

A Blocking Antibody to the Hyaluronan Receptor for Endocytosis (HARE) Inhibits Hyaluronan Clearance by Perfused Liver [PDF]

Journal of Biological Chemistry, 2003
Hyaluronan (HA) and chondroitin sulfate clearance from lymph and blood is mediated by the hyaluronan receptor for endocytosis (HARE). The purification and molecular cloning (Zhou, B., Weigel, J. A., Saxena, A., and Weigel, P. H. (2002) Mol. Biol. Cell 13, 2853-2868) of this cell surface receptor were finally achieved after we developed monoclonal ...
Janet A, Weigel, Robert C, Raymond, Carl, McGary, Anil, Singh, Paul H, Weigel   +4 more
openaire   +2 more sources

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Prognostic significance of receptor for hyaluronan acid-mediated motility (CD168) in acute pediatric leukemias – assessment of clinical outcome, post induction, end of treatment and minimal residual disease

Hematology, Transfusion and Cell Therapy, 2018
Introduction: The extracellular matrix protein hyaluronan acid plays an active in role in tumor cell proliferation and invasion. Hyaluronan acid receptors, namely CD168 or the receptor for hyaluronan acid-mediated motility (RHAMM) and CD44 have been ...
Chinnathambi Narayanan Sai Shalini, Febe Renjitha Suman, Jerusha Samuela Jacob, Rithika Rajendran, Julius Xavier Scott, Magadha Sneha Latha   +5 more
doaj   +1 more source

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, EarlyView.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

HIV infection is associated with elevated biomarkers of immune activation in Ugandan adults with pneumonia.

PLoS ONE, 2019
IntroductionPneumonia is an important cause of morbidity and mortality in persons living with human immunodeficiency virus (HIV) infection. How immune activation differs among HIV-infected and HIV-uninfected adults with pneumonia is unknown.MethodsThe ...
Richard J Wang, Julia Moore, Daniela Moisi, Emily G Chang, Patrick Byanyima, Sylvia Kaswabuli, Emmanuel Musisi, Ingvar Sanyu, Abdulwahab Sessolo, Rejani Lalitha, William Worodria, J Lucian Davis, Kristina Crothers, Jue Lin, Michael M Lederman, Peter W Hunt, Laurence Huang   +16 more
doaj   +1 more source

Identification of two hyaluronan-binding domains in the hyaluronan receptor RHAMM.

Journal of Biological Chemistry, 1993
We have identified two discrete hyaluronan- (HA) binding domains in the HA receptor RHAMM (Receptor for HA-Mediated Motility) that mediates the locomotion of H-ras transformed fibroblasts. A complete RHAMM cDNA (1.43 kilobases (kb)) was expressed as a fusion protein with pGEX-2T in Escherichia coli HB101 and was shown to bind specifically to both ...
B, Yang, L, Zhang, E A, Turley
openaire   +2 more sources

Localization of hyaluronan and the hyaluronan receptor ICAM-1 in rheumatoid synovia—a histochemical study [PDF]

Acta Orthopaedica Scandinavica, 1995
The major site for elimination of HA from the bloodstream is via receptor mediated endocytosis by liver endothelial cells (LEC) (Fraser and Laurent 1989, Laurent and Fraser 1992). The HA receptor (HAR) on LEC has been characterized and isolated from rat LEC membranes (Forsberg and Gustafson 1991).
Stefan Gustafson, Anna Engström-Laurent, Tarja Wikström, Ann-Marie Gustafson   +3 more
openaire   +1 more source

Review of articular cartilage repair techniques and their application in the horse

Equine Veterinary Journal, EarlyView.
Abstract Articular cartilage lesions represent a significant career‐limiting problem in athletic horses. A healthy articular cartilage surface is vital for optimal joint function, and defects can result in irreversible degenerative changes. Successful treatment of cartilage lesions remains a long‐standing challenge for orthopaedic surgeons, prompting ...
Charlotte K. Barton, Brad B. Nelson, Laurie R. Goodrich   +2 more
wiley   +1 more source

Hyaluronan, a Crucial Regulator of Inflammation

Frontiers in Immunology, 2014
Hyaluronan (HA), a major component of the extracellular matrix (ECM), plays a key role in regulating inflammation. Inflammation is associated with accumulation and turnover of hyaluronan polymers by multiple cell types. Increasingly through the years, HA
Aaron C Petrey, Carol A. de la Motte
doaj   +1 more source