Results 61 to 70 of about 27,596 (198)

Hyaluronan in the lymphatics: The key role of the hyaluronan receptor LYVE-1 in leucocyte trafficking [PDF]

Matrix Biology, 2019
LYVE-1, a close relative of the leucocyte receptor, CD44, is the main receptor for hyaluronan (HA) in lymphatic vessel endothelium and a widely used marker for distinguishing between blood and lymphatic vessels. Enigmatic for many years because of its anomalous HA-binding characteristics, the function of LYVE-1 has just recently been identified as that
openaire   +3 more sources

What is special about 200 kDa hyaluronan that activates hyaluronan receptor signaling? [PDF]

Glycobiology, 2017
The polydispersity of hyaluronan (HA) presents challenges for analyzing its solution properties, such as the relationship between mass and particle size. The broad mass range of natural HA (≤50-fold) makes molecular characterization difficult and ambiguous compared to molecules with known molecular weights (e.g., proteins).
Paul H, Weigel, Bruce A, Baggenstoss
openaire   +2 more sources

Purification and molecular identification of the human hyaluronan receptor for endocytosis [PDF]

Glycobiology, 2002
The clearance of hyaluronan (HA) and chondroitin sulfates from the circulating blood and lymph in the body is mediated by the membrane-bound HA receptor for endocytosis (HARE). Previously, we found that two HARE species of approximately 175 kDa and approximately 300 kDa are abundant in the sinusoidal endothelial cells in rat liver, spleen, and lymph ...
Bin, Zhou, Carl T, McGary, Janet A, Weigel, Amit, Saxena, Paul H, Weigel   +4 more
openaire   +2 more sources

Ginsenoside Rg1 Ameliorates LPS‐Induced Sepsis‐Associated Lung Injury in Mice via VEGFC/D‐VEGFR3 Signaling‐Mediated Lymphangiogenesis and Lymphatic Remodeling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐induced acute lung injury (ALI) remains challenging to treat, with conventional anti‐inflammatory therapies offering limited efficacy. The lymphatic system is crucial for removing edema and inflammatory mediators, and its impairment can exacerbate lung injury.
He Wang, Lan Hu, Chun‐Pan Zhang, Wen‐Jie Qi, Yu‐Guo Song   +4 more
wiley   +1 more source

Effects of Ferrostatin‐1 on Vocal Folds in Aging Rats

The Laryngoscope, EarlyView.
Age‐related vocal fold degeneration is associated with oxidative stress, and ferroptosis may contribute to structural changes in aging vocal folds. In this aged rat model, intracordal injection of the antioxidant ferrostatin‐1 attenuated ferroptosis‐related changes and was associated with modulation of collagen accumulation, hyaluronic acid ...
Yong‐Il Cheon, Soo‐Young Bang, Ji Min Kim, Ha‐Nee Kwon, Minhyung Lee, Eui‐Suk Sung, Jin‐Choon Lee, Byung‐Joo Lee, Sung‐Chan Shin   +8 more
wiley   +1 more source

Fluid bolus increases plasma hyaluronan concentration compared to follow-up strategy without a bolus in oliguric intensive care unit patients

Scientific Reports
Fluid therapy is a fundamental part of supportive therapy in critical care. However, it is also a suspected risk for endothelial glycocalyx degradation which is associated with poor clinical outcomes.
Maija Serlo, Nina Inkinen, Päivi Lakkisto, Miia Valkonen, Anni Pulkkinen, Tuomas Selander, Ville Pettilä, Suvi T. Vaara   +7 more
doaj   +1 more source

Utilization of Glycosaminoglycans/Proteoglycans as Carriers for Targeted Therapy Delivery

International Journal of Cell Biology, 2015
The outcome of patients with cancer has improved significantly in the past decade with the incorporation of drugs targeting cell surface adhesive receptors, receptor tyrosine kinases, and modulation of several molecules of extracellular matrices (ECMs ...
Suniti Misra, Vincent C. Hascall, Ilia Atanelishvili, Ricardo Moreno Rodriguez, Roger R. Markwald, Shibnath Ghatak   +5 more
doaj   +1 more source

Divergent temporal expression of hyaluronan metabolizing enzymes and receptors with craniotomy vs. controlled cortical impact injury in rat brain: A pilot study

Frontiers in Neurology, 2014
Traumatic brain injury triggers many secondary changes in tissue biology which ultimately determine the extent of injury and clinical outcome. Hyaluronan (hyaluronic acid, HA) is a protective cementing gel present in the intercellular spaces whose ...
Guoqiang eXing, Ming eRen, Ajay eVerma
doaj   +1 more source

Hyaluronic Acid (HA) Receptors and the Motility of Schwann Cell(-Like) Phenotypes

Cells, 2020
The cluster of differentiation 44 (CD44) and the hyaluronan-mediated motility receptor (RHAMM), also known as CD168, are perhaps the most studied receptors for hyaluronic acid (HA); among their various functions, both are known to play a role in the ...
Sihem Ouasti, Alessandro Faroni, Paul J. Kingham, Matilde Ghibaudi, Adam J. Reid, Nicola Tirelli   +5 more
doaj   +1 more source

Diagnostic Value of Glycocalyx Shedding in Blood for Differentiating between Parkinson's Disease and Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Blood–brain barrier disruption is increasingly recognized in synucleinopathies, but the role of the endothelial glycocalyx (GLX) in Parkinson's disease (PD) and multiple system atrophy (MSA) remains unclear. Objectives The aim was to determine whether plasma GLX markers differ between PD, MSA, and healthy controls (HC), relate to ...
Jonas Folke, Brian DellaValle, Mathias Lindh Jørgensen, Phillip Bredahl Mogensen, Casper Hempel, Jørgen Rungby, Anne‐Mette Hejl, Annemette Løkkegaard, Lisette Salvesen, Sara Bech, Mette Møller, Erik Hvid Danielsen, Morten Blaabjerg, Matthias Bode, Tomasz Brudek, Susana Aznar   +15 more
wiley   +1 more source