Results 71 to 80 of about 28,152 (259)

Advances in Hyaluronan Biology: Signaling, Regulation, and Disease Mechanisms [PDF]

, 2015
Hyaluronan is an extracellular glycosaminoglycan polymer consisting of linear disaccharide units containing alternating glucuronate and N-acetylglucosamine.Many cell types make hyaluronan, which unlike most other macromolecules is assembled at the ...
Larry S. Sherman, Simpson, Melanie A., Carol de la Motte, Sherman, Larry S., Paul H. Weigel, Weigel, Paul H., la Motte, Carol de, Melanie A. Simpson   +7 more
core   +1 more source

Layilin, a Novel Integral Membrane Protein, Is a Hyaluronan Receptor [PDF]

Molecular Biology of the Cell, 2001
The actin cytoskeleton plays a significant role in changes of cell shape and motility, and interactions between the actin filaments and the cell membrane are crucial for a variety of cellular processes. Several adaptor proteins, including talin, maintain the cytoskeleton-membrane linkage by binding to integral membrane proteins and to the cytoskeleton.
P, Bono, K, Rubin, J M, Higgins, R O, Hynes   +3 more
openaire   +2 more sources

CD44‐Targeting Hydroxyapatite Nanoparticles (HAP) Induce Mitochondrial Dysfunction‐Driven PANoptosis and Immunogenic Cell Death (ICD) via Ca Overload in Colorectal Cancer

Advanced Science, EarlyView.
ABSTRACT Colorectal cancer (CRC) remains therapeutically challenging due to high metastasis, recurrence, and immunotherapy resistance driven by tumor microenvironment‐mediated immune evasion. Immunogenic cell death (ICD) offers a promising strategy to reshape the immune microenvironment, yet existing ICD inducers suffer from poor targeting efficiency ...
Yao Xiao, Yuxuan Yang, Haosen Qiu, Jia Yang, Hao Liang, Zhaojun Jiang, Xiao Tong, Yongying Li, Qunfeng Huang, Jiaming Wu, Tian Lin, Jiang Yu, Min Liang   +12 more
wiley   +1 more source

Deregulation of hyaluronan synthesis, degradation and binding promotes breast cancer

, 2013
Clinical and experimental data indicate that hyaluronan accumulates in breast cancer compared with normal breast epithelium, which correlates to poor prognosis.
Kozlova, Inna,, Olofsson, Berit,, Porsch, Helena,, Heldin, Paraskevi,, Kahata, Kaoru,, Basu, Kaustuv,   +5 more
core   +1 more source

HIV infection is associated with elevated biomarkers of immune activation in Ugandan adults with pneumonia.

PLoS ONE, 2019
IntroductionPneumonia is an important cause of morbidity and mortality in persons living with human immunodeficiency virus (HIV) infection. How immune activation differs among HIV-infected and HIV-uninfected adults with pneumonia is unknown.MethodsThe ...
Richard J Wang, Julia Moore, Daniela Moisi, Emily G Chang, Patrick Byanyima, Sylvia Kaswabuli, Emmanuel Musisi, Ingvar Sanyu, Abdulwahab Sessolo, Rejani Lalitha, William Worodria, J Lucian Davis, Kristina Crothers, Jue Lin, Michael M Lederman, Peter W Hunt, Laurence Huang   +16 more
doaj   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Hyaluronan, a Crucial Regulator of Inflammation

Frontiers in Immunology, 2014
Hyaluronan (HA), a major component of the extracellular matrix (ECM), plays a key role in regulating inflammation. Inflammation is associated with accumulation and turnover of hyaluronan polymers by multiple cell types. Increasingly through the years, HA
Aaron C Petrey, Carol A. de la Motte
doaj   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Hyaluronan-oligosaccharide-induced transcription of metalloproteases

, 2022
S.359-367Activated dendritic epidermal Langerhans cells and metastatic tumour cells share many properties. Both cell types can invade the surrounding tissue, enter the lymphatic system and travel to regional lymph nodes.
Angel, P., Termeer, C., Fieber, C., Baumann, P., Herrlich, P., Sleeman, J.P., Simon, J.C., Hofmann, M., Vallon, R.   +8 more
core   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source