Results 91 to 100 of about 28,152 (259)

Are hyaluronan receptors involved in three-dimensional cell migration. [PDF]

, 2000
Hyaluronan (HA), an unbranched polysaccharide consisting of repeated glucuronic acid/Nacetylglucosamine disaccharide units, is ubiquitously present in the extracellular matrix of many tissues (for a more comprehensive review see: Fraser et al., 1997).
Nehls, V., Hayen, W.
core  

NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury.

, 2009
Inflammation under sterile conditions is a key event in autoimmunity and following trauma. Hyaluronan, a glycosaminoglycan released from the extracellular matrix after injury, acts as an endogenous signal of trauma and can trigger chemokine release in ...
Grant, Ethan P, Amirhossein Misaghi, Kenshi Yamasaki, Kristen R. Taylor, Hoffman, Hal M, Richard L. Gallo, Taylor, Kristen R, Audish, David, Bertin, John, Jun Muto, Hal M. Hoffman, Anna L. Cogen, David Audish, John Bertin, Coyle, Anthony J, Misaghi, Amirhossein, Cogen, Anna L, Muto, Jun, Yamasaki, Kenshi, Gallo, Richard L, Anthony J. Coyle, Ethan P. Grant   +21 more
core   +1 more source

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

Sexual dimorphism in the nociceptive effects of hyaluronan [PDF]

, 2020
Intradermal administration of low-molecular-weight hyaluronan (LMWH) in the hind paw induced dose-dependent (0.1, 1, or 10 µg) mechanical hyperalgesia of similar magnitude in male and female rats. However, the duration of LMWH hyperalgesia was greater in
Ivan J.M. Bonet, Jon D. Levine, Bonet, Ivan JM, Green, Paul G, Paul G. Green, Levine, Jon D   +5 more
core   +1 more source

Hyaluronan–cisplatin conjugate nanoparticles embedded in Eudragit S100-coated pectin/alginate microbeads for colon drug delivery

International Journal of Nanomedicine, 2013
Shiao-Wen Tsai,1 Ding-Syuan Yu,2 Shu-Wei Tsao,1 Fu-Yin Hsu2,3 1Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan; 2Department of Life Science, 3Institute of Bioscience and Biotechnology, National Taiwan ...
Tsai SW, Yu DS, Tsao SW, Hsu FY
doaj  

Review of articular cartilage repair techniques and their application in the horse

Equine Veterinary Journal, EarlyView.
Abstract Articular cartilage lesions represent a significant career‐limiting problem in athletic horses. A healthy articular cartilage surface is vital for optimal joint function, and defects can result in irreversible degenerative changes. Successful treatment of cartilage lesions remains a long‐standing challenge for orthopaedic surgeons, prompting ...
Charlotte K. Barton, Brad B. Nelson, Laurie R. Goodrich   +2 more
wiley   +1 more source

Activated hyaluronan metabolism in the tumor matrix — Causes and consequences

, 2019
Hyaluronan accumulates in the stroma of several solid tumors and promotes their progression. Both enhanced synthesis and fragmentation of hyaluronan are required as a part of this inflammatory process resembling wound healing. Increased expression of the
Tammi, Markku I, Markku I. Tammi, Sanna Pasonen-Seppänen, Pasonen-Seppänen, Sanna, Kirsi Rilla, Auvinen, Päivi, Sanna Oikari, Päivi Auvinen, Rilla, Kirsi, Tammi, Raija H, Raija H. Tammi, Oikari, Sanna   +11 more
core   +1 more source

Molecular size-dependent specificity of hyaluronan on functional properties, morphology and matrix composition of mammary cancer cells

Matrix Biology Plus, 2019
High levels of hyaluronan (ΗΑ), a major extracellular matrix (ECM) glycosaminoglycan, have been correlated with poor clinical outcome in several malignancies, including breast cancer.
Anastasia-Gerasimoula Tavianatou, Zoi Piperigkou, Carlo Barbera, Riccardo Beninatto, Valentina Masola, Ilaria Caon, Maurizio Onisto, Marco Franchi, Devis Galesso, Nikos K. Karamanos   +9 more
doaj   +1 more source

Hydrogel‐based drug delivery systems for intracerebral hemorrhage with therapeutic advances and emerging roles of the bone–brain axis

Interdisciplinary Medicine, EarlyView.
Hydrogel‐based drug delivery systems offer a promising approach for treating intracerebral hemorrhage (ICH) by overcoming blood‐brain barrier limitations, enabling precise, sustained release of neuroprotective and anti‐inflammatory agents. These systems enhance treatment efficacy, but challenges remain in biosafety, drug penetration, and scalability ...
Haojun Shi, Min Chen, Yisheng Chen, MengYao Li, Jiale Ma, Zuozhen Yin, Li Wu, YangBao Miao, Zemin Ou, Ke Wu, Zhijie Xu, Lizhi Li, Shaocong Zhao, Shiwei He, Bin Huang, Guanwen He, Guanghui Wu, John H. Zhang, Liang Shi   +18 more
wiley   +1 more source

Dissecting the role of hyaluronan synthases in the tumor microenvironment

, 2019
The tumor microenvironment is becoming a crucial factor in determining the aggressiveness of neoplastic cells. The glycosaminoglycan hyaluronan is one of the principal constituents of both the tumor stroma and the cancer cell surfaces, and its ...
Renato V. Iozzo, Alberto Passi, Iozzo, Renato V., Simone Buraschi, Passi, Alberto, Vigetti, Davide, Buraschi, Simone, Davide Vigetti   +7 more
core   +1 more source