Results 91 to 100 of about 27,596 (198)

Matrix Viscoelasticity: The Overlooked Architect of Solid Tumour Evolution

Organ Medicine, EarlyView.
Ruixi Huang, Yupeng Guan
wiley   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Detection of the Hyaluronan Receptor CD44 in the Bovine Oviductal Epithelium

Journal of Reproduction and Development, 2005
Hyaluronan is involved in fundamental reproductive events such as sperm storage in the female reproductive tract, fertilization, and early embryo development, these functions are presumably mediated by its major cell surface receptor, CD44. The present study was conducted to investigate the presence and localization of CD44 in the bovine oviductal ...
BERGQVIST, Ann-Sofi, YOKOO, Masaki, BÅGE, Renée, SATO, Eimei, RODRÍGUEZ-MARTÍNEZ, Heriberto   +4 more
openaire   +3 more sources

Transcriptome Analysis Reveals Distinct Molecular Signatures Between Erosive and Non‐Erosive Oral Lichen Planus

Oral Diseases, EarlyView.
ABSTRACT Objectives To identify molecular mechanisms distinguishing the erosive subtype of oral lichen planus (EOLP) from the non‐erosive subtype (NEOLP) through transcriptomic analysis. Methods We analysed bulk RNA‐seq data from 30 buccal mucosa samples (13 EOLP, 17 NEOLP) using differential expression, Gene Set Enrichment Analysis (GSEA ...
Kisung Sheen, Chaerim Song, Kanghyun Kwon, Seoyeon Kim, Hye‐Ji Park, Man S. Kim   +5 more
wiley   +1 more source

Crohn’s Disease Fibroblasts Overproduce the Novel Protein KIAA1199 to Create Proinflammatory Hyaluronan FragmentsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2016
Background & Aims: Crohn’s Disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. Fibrosis, a serious complication of CD, occurs when activated intestinal fibroblasts deposit excessive amounts of extracellular matrix (ECM) in ...
Artin Soroosh, Sami Albeiroti, Gail A. West, Belinda Willard, Claudio Fiocchi, Carol A. de la Motte   +5 more
doaj   +1 more source

The High‐Intensity Zone: A Dynamic Inflammatory Hub in Lumbar Disc Degeneration

Orthopaedic Surgery, EarlyView.
The HIZ, a dynamic inflammatory hub in lumbar disc degeneration, links inflammation‐degeneration‐pain; integrating advanced diagnostics and targeted therapies offers precise management for discogenic low back pain. ABSTRACT The lumbar intervertebral disc high‐intensity zone (HIZ), a focal hyperintensity within the annulus fibrosus on T2‐weighted ...
Qi Zhou, Jingyi Cai, Weijian Zhu, Sirui Zhou, Liling Zhou, Yiyao Pei, Gang Wu   +6 more
wiley   +1 more source

Hyaluronic acid metabolism and chemotherapy resistance: recent advances and therapeutic potential

Molecular Oncology
Hyaluronic acid (HA) is a major component of the extracellular matrix, providing essential mechanical scaffolding for cells and, at the same time, mediating essential biochemical signals required for tissue homeostasis.
Zhanhong Liu, Pengbo Hou, Jiankai Fang, Changshun Shao, Yufang Shi, Gerry Melino, Angelo Peschiaroli   +6 more
doaj   +1 more source

Layilin: a multifunctional hyaluronan receptor in physiology and pathology

Frontiers in Oncology
Layilin (encoded by LAYN ), a C-type lectin transmembrane receptor, serves as a critical molecular bridge between extracellular matrix (ECM) sensing and intracellular signaling through its interaction with cytoskeletal adaptors. Initially identified for its cytoskeletal functions, layilin has
Jin, Chenchen, Zong, Yunfeng
openaire   +2 more sources

Understanding exosomes in facial esthetics and skin aging

Periodontology 2000, EarlyView.
Abstract Background Skin aging is a multifactorial process mediated by intrinsic (genetic and metabolic) and extrinsic (environmental) factors leading to functional and structural deterioration, including wrinkles, loss of collagen and elastin, as well as various pigmentation disorders.
Richard J. Miron, Catherine Davies, Anton Sculean, Paras Ahmad   +3 more
wiley   +1 more source

Impacts of Hyaluronan on Extracellular Vesicle Production and Signaling

Cells
Hyaluronan (HA) is a critical component of cell and tissue matrices and an important signaling molecule. The enzymes that synthesize and process HA, as well as the HA receptors through which the signaling properties of HA are transmitted, have been ...
Melanie A. Simpson
doaj   +1 more source