Results 131 to 140 of about 9,091 (172)

CD46 in Meningococcal Disease

Science, 2003
The human-specific bacterial pathogen Neisseria meningitidis is a major cause of sepsis and/or meningitis. The pili of N. meningitidis interact with CD46, a human cell-surface protein involved in regulation of complement activation.
Linda, Johansson, Anne, Rytkonen, Peter, Bergman, Barbara, Albiger, Helena, Källström, Tomas, Hökfelt, Birgitta, Agerberth, Roberto, Cattaneo, Ann-Beth, Jonsson   +8 more
openaire   +2 more sources

CD46 in Neisseria pathogenesis

Trends in Molecular Medicine, 2004
CD46 is a complement regulator that serves as a cellular pilus receptor for the human pathogens Neisseria gonorrhoeae and Neisseria meningitidis . The role of CD46 in N. gonorrhoeae infection has been further characterized through the identification of domains that are required for bacterial adhesion, as well as the delineation of CD46-dependent ...
Darcy B, Gill, John P, Atkinson
openaire   +2 more sources

CD46: The ‘multitasker’ of complement proteins

The International Journal of Biochemistry & Cell Biology, 2013
Complement is undeniably quintessential for innate immunity by detecting and eliminating infectious microorganisms. Recent work, however, highlights an equally profound impact of complement on the induction and regulation of a wide range of immune cells.
Yamamoto, Hidekazu; Fara, Antonella Francesca; Dasgupta, Prokar; Kemper, Claudia   +4 more
openaire   +3 more sources

Measles Virus and CD46

2008
Measles virus (MV) was isolated in 1954 (Enders and Peeble 1954). It is among the most contagious of viruses and a leading cause of mortality in children in developing countries (Murray and Lopez 1997; Griffin 2001; Bryce et al. 2005). Despite intense research over decades on the biology and pathogenesis of the virus and the successful development in ...
C, Kemper, J P, Atkinson
openaire   +2 more sources

Interaction of Measles Virus (Hallé Strain) with CD46: Evidence That a Common Binding Site on CD46 Facilitates Both CD46 Downregulation and MV Infection

Biochemical and Biophysical Research Communications, 1999
CD46 acts as a cellular receptor for vaccine strains of measles virus (MV). The MV/CD46 interaction-mediated by the MV attachment glycoprotein, the hemagglutinin (H)-not only facilitates infection but also induces CD46 downregulation. A conflict of opinion exists as to whether a single MVH binding site on CD46, or two separate sites, facilitates the ...
V, Lecouturier, A, Rizzitelli, J, Fayolle, L, Daviet, F T, Wild, R, Buckland   +5 more
openaire   +2 more sources

Measles virus receptors: SLAM and CD46

Reviews in Medical Virology, 2004
AbstractThe success of vaccination against measles in developed countries has significantly reduced the incidence of measles‐related morbidity and mortality. However, measles is still the leading cause of mortality in children from underdeveloped countries due to low vaccination coverage, high transmissibility of the measles virus as well as primary ...
Neelam, Dhiman, Robert M, Jacobson, Gregory A, Poland   +2 more
openaire   +2 more sources

CD46: expanding beyond complement regulation

Trends in Immunology, 2004
During the 1980s CD46 was discovered in a search for C3b binding proteins of human peripheral blood cells. Its role as an inactivator of C3b and C4b deposited on self-tissue is highlighted by the observation that partial deficiency of CD46 is a predisposing factor to hemolytic uremic syndrome.
Rebecca C, Riley-Vargas, Darcy B, Gill, Claudia, Kemper, M Kathryn, Liszewski, John P, Atkinson   +4 more
openaire   +2 more sources

Emerging roles and new functions of CD46

Springer Seminars in Immunopathology, 2005
In the past 20 years, our understanding of the workings of complement regulatory protein, CD46 (membrane cofactor protein), has grown as has the impressive list of pathogens interacting with this membrane-bound complement inhibitor. Referred to as a "pathogen magnet," CD46 serves as a receptor for seven human pathogens. Initially discovered as a widely
M Kathryn, Liszewski, Claudia, Kemper, Jeffrey D, Price, John P, Atkinson   +3 more
openaire   +2 more sources

Adenovirus 11p downregulates CD46 early in infection

Virology, 2010
Adenovirus 11 prototype (Ad11p), belonging to species B, uses CD46 as an attachment receptor. CD46, a complement regulatory molecule, is expressed on all human nucleated cells. We show here that Ad11p virions downregulate CD46 on the surface of K562 cells as early as 5min p.i.
Yafang Mei, Kristina Lindman
exaly   +3 more sources

Linking Immune Responses by CD46

Science Signaling, 2002
Marie et al. proposed that the transmembrane glycoprotein CD46, which functions in the activation of complement in the innate immune system, also regulates inflammatory responses of T cells in acquired immunity. CD46 not only binds the C3b and C4b complement products, but is also a receptor for measles and other ...
openaire   +2 more sources