Results 231 to 240 of about 665,801 (300)

Defective IL-17 production is associated with reduced IL-1β levels in response to <i>Mycobacterium tuberculosis</i> in HIV+ children with latent tuberculosis infection. [PDF]

Front Immunol
Devalraju KP, Mallidi V, Vankayalapati A, Radhakrishnan RK, Bogam AK, Prasad S, Dangatla SV, Joshi S, Nandicoori VK, Valluri VL, Vankayalapati R, Neela VSK.   +11 more
europepmc   +1 more source

TREM2+ Macrophages Promote Immune Evasion in Endometriosis Through BAG3‐Associated Regulation of CD8+ T Cell Autophagy

Advanced Science, EarlyView.
TREM2+ macrophages are enriched in endometriosis and suppress CD8+ T cell function through SPP1–CD44 communication and BAG3‐associated autophagy regulation. Genetic TREM2 deficiency restores cytotoxic lymphocyte activity, whereas antibody‐mediated TREM2 blockade reduces ectopic lesion growth, highlighting TREM2 as a potential non‐hormonal therapeutic ...
Ming Yuan, Xue Jiao, Le Xu, Qianhui Ren, Shuang Wang, Zhaoyang Zhong, Na Li, Qiuju Li, Xiaoli Meng, Guoyun Wang   +9 more
wiley   +1 more source

Cholesterol 25-Hydroxylase Deficiency Provides an Optimal and Durable Protective T Helper 1 Immunity via Interleukin-12-Interleukin-2 Axis in BCG-Vaccinated Mice. [PDF]

MedComm (2020)
Kim H, Choi E, Kwon KW, Choi HH, Kim K, Jung W, Shin SJ.   +6 more
europepmc   +1 more source

In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma

Advanced Science, EarlyView.
By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He, Duo Yu, Fei Xie, Kaisheng Hou, Zhaozhao Li, Meifang Dai, Jingyi Yun, Haiyan Cao, Yang Xiao, Yueyuan Qiu, Gege Shi, Wangqian Zhang, Shuning Wang, Qiang Hao, Jieyu Zhang, Zhaowei Wang, Yingqi Zhang, Kuo Zhang, Jintao Gu, Haichen Du, Meng Li   +20 more
wiley   +1 more source

Human leukocyte antigen genotype modulates cytomegalovirus- and Epstein-Barr virus-specific T-cell response in healthy donors for optimized virus-specific T-cell donor selection. [PDF]

Front Immunol
Mora-Buch R, Pasamar H, Tomás-Marín M, Enrich E, Andrés-Rozas M, Peña-Gómez C, García Bosca M, Rudilla F.   +7 more
europepmc   +1 more source

Combined Immune‐Peptide Nanofiber with HSP70/AKT/mTOR Axis Blockade Enhances Photothermal Immunotherapy, Inhibiting Tumor Growth and Recurrence

Advanced Science, EarlyView.
A carrier‐free peptide‐guided PSP@IR‐CF3 nanofiber system integrates PD‐L1 targeting and photothermal immunotherapy for enhanced cancer treatment. By revealing PTIT‐induced activation of the HSP70/AKT/mTOR pathway and incorporating mTOR inhibition, this strategy effectively overcomes therapeutic resistance and prevents tumor recurrence, providing a ...
Xinyu Zhang, Zhenqi Jiang, Wenjia Zhang, Juncheng Wu, Haozhuo Guo, Changlei Li, Mingwei Sun, Xiaoying Tang, Yue Zhang, Wei Huang, Huadan Xue, Yang Du   +11 more
wiley   +1 more source

Next-Generation Cancer Nanovaccines: Reprogramming the Tumor Microenvironment from Rational Design Toward Clinical Translation. [PDF]

Int J Nanomedicine
Tabibzadeh S, Meng F, Asghariazar V, Safarzadeh E, Esmaeili A, Ten Hagen TLM, Farhoudi L, Cai Y.   +7 more
europepmc   +1 more source

BRCA1 Mutation‐Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING‐Associated Antitumor Immunity in Ovarian Cancer

Advanced Science, EarlyView.
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang, Mengying Yao, Jinhui Xie, Dingjie Wang, Yashi Shi, Xiaodan Mao, Chunhua Lu, Pengming Sun   +7 more
wiley   +1 more source

Recombinant Antibody Vaccines for Targeted Antigen Delivery: Design Principles and Immunological Applications. [PDF]

Vaccines (Basel)
Pirogovsky KM, Hawiger D.
europepmc   +1 more source

An adenovirus-based multiantigen vaccine protects against tuberculosis by coordinating adaptive immunity and curbing immunosuppressive mechanisms. [PDF]

Microbiol Spectr
Wei L, Wang P, Li Y, Li X, Shen X, He F, Guo Y, Xing M, Zhou D.   +8 more
europepmc   +1 more source