Results 251 to 260 of about 306,421 (309)

Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

Animal Models and Experimental Medicine, EarlyView.
Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley   +1 more source

Vaccination Against Pathogens Targeting Cell-Derived Cryptic Antigens. [PDF]

J Infect Dis
Clark ES, Garrido G, Levay A, Schrand B, Gilboa E.   +4 more
europepmc   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

RNA-based co-transfer of human CD8αβ with WT1-specific TCRαβ redirects tumor recognition by CD4 and γδ T-cells towards MHC class I-restricted WT1 epitopes and boosts CD8 T-cell responses with or without CD3 mRNA. [PDF]

Exp Hematol Oncol
Campillo-Davo D, Flumens D, Berneman ZN, Fujiki F, Roex G, Versteven M, Van Acker HH, Van Tendeloo VFI, Sugiyama H, Anguille S, Lion E.   +10 more
europepmc   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Modes of the initiation of T cell-mediated immune responses. [PDF]

Med Rev (2021)
Li L, Yao Z.
europepmc   +1 more source

Targeting Telomerase in Cancer: Vaccine-Based Strategies, Clinical Evidence, and Synergy with Immunotherapy. [PDF]

Diseases
Baliou S, Tzatzarakis MN, Tsantes AG, Vakonaki E, Ioannou P, Kyriakakis M, Hatzidaki E, Pelagiadis I, Stiakaki E, Tsatsakis A.   +9 more
europepmc   +1 more source

<i>Ascaris lumbricoides</i> antigen exposure modulates T cell activation via regulation of IL-15Rα expression, STAT5 phosphorylation, and promotes differentiation of BCL6^low B cells. [PDF]

Front Immunol
Pushpamithran G, Appelgren D, Gilman RH, Blomgran R.   +3 more
europepmc   +1 more source

Mutant KRAS vaccine with dual checkpoint blockade in resected pancreatic cancer: a phase I trial. [PDF]

Nat Commun
Huff AL, Haldar SD, Girgis AA, Wang HH, Danilova L, Heumann T, Berg M, Wang Y, Andaloori L, Hernandez A, Longway G, Barrett B, Zhu Z, Davis-Marcisak E, Thoburn C, Leatherman J, Mitchell S, Lee JW, Shu DH, Konig MF, Mog BJ, Montagne J, Coyne EM, Bever K, Baretti M, Yarchoan M, Anders RA, Kagohara LT, Laheru D, Thomas AM, Durham J, Nauroth JM, Lu J, Wang H, Fertig EJ, Ho WJ, Azad NS, Jaffee EM, Zaidi N.   +38 more
europepmc   +1 more source

The T-cell receptor repertoire of wild mice. [PDF]

Discov Immunol
Cohen JA, Hunter-Barnett S, Nageswaran G, Byrne S, Freeman G, Cowley MV, Chain B, Viney M.   +7 more
europepmc   +1 more source