Results 251 to 260 of about 665,801 (300)

Modulation of CD4 by antigenic activation.

The Journal of Immunology, 1987
Abstract Cell surface expression of CD4, an invariant membrane glycoprotein, is characteristic of the MHC class II-restricted T cell helper/inducer subset. Although the specificity and restriction patterns of T lymphocytes are determined by the T cell receptor for antigen, CD4 might represent an additional "interaction" molecule that is ...
C M, Weyand, J, Goronzy, C G, Fathman
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Polymorphism of the CD4 and CD5 differentiation antigens in cattle

Veterinary Immunology and Immunopathology, 1991
Monoclonal antibodies (mAbs) specific for bovine CD4 and CD5 antigens have been found to identify polymorphic determinants on these molecules. In the case of CD5, mAb IL-A67 recognises one allotypic form of the antigen while four other CD5-specific mAbs in the workshop (CC17, CC29, BLT-1 and 8C11) recognise a second allotype.
W I, Morrison, C J, Howard, C A, Hinson
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Characterization of Mouse CD4 TCR and Its Targeting Antigen

2022
The initial step of activation and differentiation of naïve CD4+ T cells is the TCR-antigenic stimulation. The specific antigen peptides (>11 residues) are presented by the class II MHC (MHC II) protein which expresses professional antigen-presenting cells (APCs).
Wenhua, Liang, Feng, Wang
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Antigen Presentation by the CD4 Positive Monocyte Subset

Journal of Leukocyte Biology, 1990
Abstract Although CD4 antigen is expressed on monocytes (MØ), its functional role is uncharacterized. In this study, isolated human MØ were separated into CD4+ and CD4- MØ subsets and assessed for presentation of tetanus toxoid. The CD4- MØ subset had decreased antigen presenting cell (APC) capacity as well as increased PGE2 production ...
Szabo, Gyongyi, Miller-Graziano, Carol L., Kodys, Karen   +2 more
openaire   +3 more sources

Mining the CD4 Antigen Repertoire for Next-Generation Tuberculosis Vaccines

Cell
Tuberculosis (TB) is the leading cause of death from infectious disease worldwide, and Bacillus Calmette-Guérin (BCG) remains the only clinically approved vaccine. An enduring challenge in TB vaccine development is systematic antigen selection from a large repertoire of potential candidates.
Dan H. Barouch, Erica N Borducchi, Alejandro A Espinosa Perez   +2 more
exaly   +4 more sources

Species Heterogeneity in Macrophage Expression of the CD4 Antigen. [PDF]

Journal of Experimental Medicine, 1987
The CD4 antigen is expressed on T cells of all mammalian species examined and appears to play an important role in the response of T cells to antigen. In humans, the molecule acts as a receptor for the AIDS virus. Previous studies have demonstrated that M phi in the rat and human also express the CD4 antigen, which is indistinguishable from that on T ...
Siamon Gordon, P R Crocker
exaly   +3 more sources

Structure prediction and antigenic site determination of CD4 antigen

International Journal of Medical Engineering and Informatics, 2010
CD antigen are playing vital role in many diseases. The human CD4 molecule binds both human immunodeficiency virus (HIV) envelope protein gp120 and class II major histocompatibility complex (MHC) molecules. This binding help for the internalisation of HIV and its replication in host CD4 T-cells concentration fall drastically, a disastrous fall in CD4 T-
openaire   +1 more source

An immunoglobulin light chain dimer with cd4 antigen specificity

Molecular Immunology, 1987
A subclone that had lost its IgG1 heavy chain was derived from a hybridoma cell line G17-2 that produces an anti-CD4 monoclonal antibody. This subclone was found to secrete a kappa light chain dimer (LCD) that could bind to the CD4 antigen expressed on a subset of human T lymphocytes.
J A, Ledbetter, H P, Fell, L S, Grosmaire, N A, Norris, T T, Tsu   +4 more
openaire   +2 more sources

Analysis of monoclonal antibodies reactive with the porcine CD4 antigen

Veterinary Immunology and Immunopathology, 1994
As result of the First International Swine CD Workshop, four monoclonal antibodies (mAb) (#002, 054, 118, and 127) clustered closely to the internal standard anti-porcine CD4 mAb, 74-12-4. To further characterize the relationship between these mAb, they were used in flow cytometry to inhibit binding of 74-12-4 to porcine lymphocytes. mAb #002 (74-12-4)
Pescovitz, M. D., Aasted, B., Canals, A., Domínguez, Javier, Sánchez-Vizcaíno, J. M., Pospisil, R., Trebichavsky, I., Salmon, H., Valpotic, I., Davis, William, Arn, S., Sachs, David H., Lunney, J. K., Zuckermann, F., Weiland, E., Saalmüller, A.   +15 more
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The Role of CD4 Antigen in HIV Infection

1989
Ever since the initial description of acquired immune deficiency syndrome (AIDS), it has been known that a specific depletion of CD4+ T-lymphocytes in the peripheral blood accompanies the onset of immunodeficiency (Gottlieb et al 1981). Following the discovery of HIV-1, Klatzmann et al (1984a) showed that the virus had a distinct tropism for and ...
R. A. Weiss, P. R. Clapham, J. A. McKeating   +2 more
openaire   +1 more source