Results 261 to 270 of about 665,801 (300)

Antigen presentation and the regulation of CD4 memory generation to influenza

Expert Review of Clinical Immunology, 2006
Influenza virus epidemics are responsible for approximately 1 million human deaths annually, and a pandemic caused by H5N1 avian influenza viruses could result in over 50 million deaths. Current vaccine strategies cannot prevent the first wave of an influenza pandemic because their formulation is virus-strain specific and requires advance knowledge of ...
Dawn, Jelley-Gibbs, Laura, Haynes, Susan, Swain   +2 more
openaire   +2 more sources

Down-regulation of lymphocyte CD4 antigen expression by administration of anti-CD4 monoclonal antibody

Clinical Immunology and Immunopathology, 1992
Modulation of surface CD4 antigen expression was assessed by flow cytometry after calibration with 125I-labeled anti-CD4 monoclonal antibodies (mAbs). Three patients with severe psoriasis treated with BB14 (anti-CD4 mouse IgG1) and five patients with rheumatoid arthritis treated with BL4 (anti-CD4 mouse IgG2a) were analyzed for sequential changes in ...
P, Morel, J F, Nicolas, J, Wijdenes, J P, Revillard   +3 more
openaire   +2 more sources

Antigen-Specific CD4+ Regulatory T Cells in the Intestine

Inflammation & Allergy-Drug Targets, 2006
Mucosal surfaces, especially the gastrointestinal (GI) tract, are obligatory sites for tolerance induction against numerous exogenous antigens. Therefore, the mucosal surface seems to provide a microenvironment conductive to the induction of antigen-specific regulatory T cells.
openaire   +2 more sources

Original Antigenic Sin in CD4 + T Cells

Immunology
ABSTRACT Original antigenic sin (OAS) describes the phenomenon in which prior exposure to an antigen weakens the adaptive antibody response to a subsequent heterologous infection. This phenomenon can diminish the effectiveness of immunity acquired through vaccination or previous infections.
Mingran Zhang, Junling Ma, Meili Li
openaire   +2 more sources

CD4+ T cell antigen discovery in sarcoidosis

The Journal of Immunology, 2019
Abstract Sarcoidosis is an inflammatory granulomatous disease that primarily affects the lung. It has a worldwide distribution and affects individuals of all ages, races and both sexes. Despite the prevalence of the disease and continued investigation, the cause of sarcoidosis remains unknown.
Sarah A Greaves, Angela Mitchell, Michael Falta, Radleigh Santos, Clemencia A Pinilla, Andrew P Fontenot   +5 more
openaire   +1 more source

Molecular Analysis of the Interaction of p56lck with the CD4 and CD8 Antigens

1991
The CD4 and CD8 antigens on the surface of T cells appear to bind to major histocompatibility complex (MHC) class II and I antigens, respectively. These antigens also synergize with the Ti(TcR)/CD3 complex in the potentiation of T-cell proliferation. Our earlier work demonstrated that the CD4 and CD8 receptors are coupled to a protein-tyrosine kinase ...
C E, Rudd, E K, Barber, K E, Burgess, J Y, Hahn, A D, Odysseos, M S, Sy, S F, Schlossman   +6 more
openaire   +2 more sources

Antigen processing and CD4+ T cell depletion in AIDS

Cell, 1988
e infection of T lymphocytes by HIV-1 can be blocked by anti-CD4 monoclonal antibodies (Dalgleish et al., Nature 372,763-767,1984; Klatzmann et al., ibid., 767-768); * HIV-1 envelope (env) giycoprotein (gp120) binds specifically to the CD4 molecule present on helper/inducer T lymphocytes (McDougal et al., Science 237, 382-385, 1986); and expression of ...
openaire   +2 more sources

Down-regulation of CD4 molecules by the expression of Nef: a quantitative analysis of CD4 antigens on the cell surfaces

International Immunology, 1993
Nef is one of the non-structural genes encoded by human immunodeficiency viruses. The protein product is associated with the cellular and plasma membranes, and is synthesized soon after entry of the virus. However, little is known about its functions relevant to viral replication and cytopathogenesis.
M, Inoue, Y, Koga, D, Djordjijevic, T, Fukuma, E P, Reddy, M M, Yokoyama, K, Sagawa   +6 more
openaire   +2 more sources

NEOSPORA CANINUM ANTIGENS DEFINED BY ANTIGEN-DEPENDENT BOVINE CD4⁺T CELLS

Journal of Parasitology, 2005
Neosporosis is an important cause of pregnancy loss in cattle worldwide. The objective of the present study was to identify Neospora caninum antigens as vaccine candidates using antigen-specific, short-term CD4+ T cells established from N. caninum-immunized and -challenged cows. Whole N.
Wenbin, Tuo, Raymond H, Fetterer, William C, Davis, Mark C, Jenkins, J P, Dubey   +4 more
openaire   +2 more sources

Characteristics of antigen‐independent and antigen‐dependent interaction of dendritic cells with CD4⁺ T cells

European Journal of Immunology, 1995
AbstractDendritic cells (DC) are the main antigen‐presenting cells for the initiation of primary T cell‐mediated immune responses. In the first stage of activation, T cells bind to DC in an antigen‐independent manner. We studied the adhesion characteristics of human CD4+ T cells to DC generated from CD34+ hematopoietic progenitors following 12 to 13 ...
P, Hauss, F, Selz, M, Cavazzana-Calvo, A, Fischer   +3 more
openaire   +3 more sources