Results 281 to 290 of about 221,142 (316)

An immunoglobulin light chain dimer with cd4 antigen specificity

Molecular Immunology, 1987
A subclone that had lost its IgG1 heavy chain was derived from a hybridoma cell line G17-2 that produces an anti-CD4 monoclonal antibody. This subclone was found to secrete a kappa light chain dimer (LCD) that could bind to the CD4 antigen expressed on a subset of human T lymphocytes.
J A, Ledbetter, H P, Fell, L S, Grosmaire, N A, Norris, T T, Tsu   +4 more
openaire   +2 more sources

Structure prediction and antigenic site determination of CD4 antigen

International Journal of Medical Engineering and Informatics, 2010
CD antigen are playing vital role in many diseases. The human CD4 molecule binds both human immunodeficiency virus (HIV) envelope protein gp120 and class II major histocompatibility complex (MHC) molecules. This binding help for the internalisation of HIV and its replication in host CD4 T-cells concentration fall drastically, a disastrous fall in CD4 T-
openaire   +1 more source

Antigen presentation and the regulation of CD4 memory generation to influenza

Expert Review of Clinical Immunology, 2006
Influenza virus epidemics are responsible for approximately 1 million human deaths annually, and a pandemic caused by H5N1 avian influenza viruses could result in over 50 million deaths. Current vaccine strategies cannot prevent the first wave of an influenza pandemic because their formulation is virus-strain specific and requires advance knowledge of ...
Dawn, Jelley-Gibbs, Laura, Haynes, Susan, Swain   +2 more
openaire   +2 more sources

Down-regulation of lymphocyte CD4 antigen expression by administration of anti-CD4 monoclonal antibody

Clinical Immunology and Immunopathology, 1992
Modulation of surface CD4 antigen expression was assessed by flow cytometry after calibration with 125I-labeled anti-CD4 monoclonal antibodies (mAbs). Three patients with severe psoriasis treated with BB14 (anti-CD4 mouse IgG1) and five patients with rheumatoid arthritis treated with BL4 (anti-CD4 mouse IgG2a) were analyzed for sequential changes in ...
P, Morel, J F, Nicolas, J, Wijdenes, J P, Revillard   +3 more
openaire   +2 more sources

The Role of CD4 Antigen in HIV Infection

1989
Ever since the initial description of acquired immune deficiency syndrome (AIDS), it has been known that a specific depletion of CD4+ T-lymphocytes in the peripheral blood accompanies the onset of immunodeficiency (Gottlieb et al 1981). Following the discovery of HIV-1, Klatzmann et al (1984a) showed that the virus had a distinct tropism for and ...
R. A. Weiss, P. R. Clapham, J. A. McKeating   +2 more
openaire   +1 more source

Antigen-Specific CD4+ Regulatory T Cells in the Intestine

Inflammation & Allergy-Drug Targets, 2006
Mucosal surfaces, especially the gastrointestinal (GI) tract, are obligatory sites for tolerance induction against numerous exogenous antigens. Therefore, the mucosal surface seems to provide a microenvironment conductive to the induction of antigen-specific regulatory T cells.
openaire   +2 more sources

Original Antigenic Sin in CD4+ T Cells

Immunology
ABSTRACTOriginal antigenic sin (OAS) describes the phenomenon in which prior exposure to an antigen weakens the adaptive antibody response to a subsequent heterologous infection. This phenomenon can diminish the effectiveness of immunity acquired through vaccination or previous infections.
Mingran Zhang, Junling Ma, Meili Li
openaire   +2 more sources

CD4+ T cell antigen discovery in sarcoidosis

The Journal of Immunology, 2019
Abstract Sarcoidosis is an inflammatory granulomatous disease that primarily affects the lung. It has a worldwide distribution and affects individuals of all ages, races and both sexes. Despite the prevalence of the disease and continued investigation, the cause of sarcoidosis remains unknown.
Sarah A Greaves, Angela Mitchell, Michael Falta, Radleigh Santos, Clemencia A Pinilla, Andrew P Fontenot   +5 more
openaire   +1 more source

Molecular Analysis of the Interaction of p56lck with the CD4 and CD8 Antigens

1991
The CD4 and CD8 antigens on the surface of T cells appear to bind to major histocompatibility complex (MHC) class II and I antigens, respectively. These antigens also synergize with the Ti(TcR)/CD3 complex in the potentiation of T-cell proliferation. Our earlier work demonstrated that the CD4 and CD8 receptors are coupled to a protein-tyrosine kinase ...
C E, Rudd, E K, Barber, K E, Burgess, J Y, Hahn, A D, Odysseos, M S, Sy, S F, Schlossman   +6 more
openaire   +2 more sources

Antigen processing and CD4+ T cell depletion in AIDS

Cell, 1988
e infection of T lymphocytes by HIV-1 can be blocked by anti-CD4 monoclonal antibodies (Dalgleish et al., Nature 372,763-767,1984; Klatzmann et al., ibid., 767-768); * HIV-1 envelope (env) giycoprotein (gp120) binds specifically to the CD4 molecule present on helper/inducer T lymphocytes (McDougal et al., Science 237, 382-385, 1986); and expression of ...
openaire   +2 more sources