Results 291 to 300 of about 221,142 (316)

Down-regulation of CD4 molecules by the expression of Nef: a quantitative analysis of CD4 antigens on the cell surfaces

International Immunology, 1993
Nef is one of the non-structural genes encoded by human immunodeficiency viruses. The protein product is associated with the cellular and plasma membranes, and is synthesized soon after entry of the virus. However, little is known about its functions relevant to viral replication and cytopathogenesis.
M, Inoue, Y, Koga, D, Djordjijevic, T, Fukuma, E P, Reddy, M M, Yokoyama, K, Sagawa   +6 more
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NEOSPORA CANINUM ANTIGENS DEFINED BY ANTIGEN-DEPENDENT BOVINE CD4⁺T CELLS

Journal of Parasitology, 2005
Neosporosis is an important cause of pregnancy loss in cattle worldwide. The objective of the present study was to identify Neospora caninum antigens as vaccine candidates using antigen-specific, short-term CD4+ T cells established from N. caninum-immunized and -challenged cows. Whole N.
Wenbin, Tuo, Raymond H, Fetterer, William C, Davis, Mark C, Jenkins, J P, Dubey   +4 more
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Characteristics of antigen‐independent and antigen‐dependent interaction of dendritic cells with CD4⁺ T cells

European Journal of Immunology, 1995
AbstractDendritic cells (DC) are the main antigen‐presenting cells for the initiation of primary T cell‐mediated immune responses. In the first stage of activation, T cells bind to DC in an antigen‐independent manner. We studied the adhesion characteristics of human CD4+ T cells to DC generated from CD34+ hematopoietic progenitors following 12 to 13 ...
P, Hauss, F, Selz, M, Cavazzana-Calvo, A, Fischer   +3 more
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Antigen presentation to naive CD4 T cells in the lymph node

Nature Immunology, 2003
Although the presentation of peptide-major histocompatibility complex class II (pMHC class II) complexes to CD4 T cells has been studied extensively in vitro, knowledge of this process in vivo is limited. Unlike the in vitro situation, antigen presentation in vivo takes place within a complex microenvironment in which the movements of antigens, antigen-
Andrea A, Itano, Marc K, Jenkins
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Interaction of CD4 with HLA class II antigens and HIV gp120

Immunogenetics, 1991
We have developed a cellular adhesion assay in which B lymphocytes expressing HLA class II antigens form rosettes with COS cells expressing high levels of cell surface CD4 upon transient transfection with a CDM8-CD4 plasmid construct. The assay is specific, quantitative, and overcomes the difficulties encountered with a previously described system ...
PIATIERTONNEAU, D, GASTINEL, LN, AMBLARD, F, WOJCIK, M, VAIGOT, P, AUFFRAY, C   +5 more
openaire   +3 more sources

The Generation and Antigen-Specificity of CD4+CD25+ Regulatory T Cells

Inflammation & Allergy-Drug Targets, 2006
CD4+CD25+ regulatory T cells are essential components of the immune system. They help to maintain immune tolerance by exerting suppressive effects on cells of the adaptive and innate immune system. In the last few years there has been an abundance of papers addressing the suppressive effects of CD4+CD25+ regulatory T cells and their putative role in ...
Taams, L, Curnow, SJ, Vukmanovic-Stejic, M, Akbar, AN   +3 more
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Antigen-Induced T Cell Death Is Regulated by CD4 Expression

International Reviews of Immunology, 2001
Activation induced cell death (AICD) is a major physiologic pathway that regulates T cell homeostasis. In CD4 T cells, AICD is mediated mainly through Fas/FasL interactions. Although TCR occupancy triggers AICD, the contribution of its tightly associated CD4 coreceptor to the process that leads to AICD is not known. Here we show that CD4 molecule plays
A R, Hamad, J P, Schneck
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Production of monoclonal antibody to CD4 antigen and development of reagent for CD4+ lymphocyte enumeration.

Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1999
A hybridoma secreting monoclonal antibody (mAb) specific to CD4 protein was generated. This monoclonal antibody, named MT4, was proved to be specific to CD4 protein as it reacted with CD4-DNA transfected COS cells, CD4+ cell lines and CD4+ lymphocytes.
W, Kasinrerk, N, Tokrasinwit, P, Naveewongpanit   +2 more
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Inhibition of T‐cell responses by CD4 on an antigen‐presenting cell

APMIS, 2006
In addition to T‐helper cells, CD4 is expressed on monocytes, macrophages and dendritic cells. To see whether CD4 molecules on antigen‐presenting cells affect T‐cell responses, we expressed CD4 on Raji cells, and compared positive and negative cells as stimulator cells for peripheral blood mononuclear cells in mixed lymphocyte reactions.
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Antigen processing for presentation to CD4+ T cells.

The New biologist, 1992
The immune system surveys the organism for the presence of foreign or abnormal structures. An important role in the immune response is assumed by T lymphocytes that recognize foreign antigen while tolerating self-proteins. T lymphocytes can recognize only peptide fragments that are presented to them by molecules of the major histocompatibility complex (
openaire   +1 more source