Immunity to self co-generates regulatory T cells [PDF]
, 2008 Immune responses to self are kept in check by tolerance mechanisms, including suppression by regulatory T cells (Tregs). The defective generation of Tregs specific for self-antigens may lead to autoimmune disease.
Kent P. Jensen +8 more
core
CD4+ T cell proliferation following incubation of PBMCs with different antigens, plus IL-2.
, 2016 CD4+ T cell proliferation following incubation of PBMCs with different antigens, plus IL-2.
Muhammad Saleem (377032) +6 more
core +1 more source
Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis [PDF]
, 2010 Studies on Mycobacterium tuberculosis (MTB) antigens are important to improve immunodiagnostics and vaccine efficacy. A novel genome based strategy for antigen discovery is to relate what is highly expressed by bacilli in vivo or in vitro, to what is ...
Gideon, Hannah Priyadarshini
core +1 more source
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
CD4+CD25hiFOXP3+ cells in cord blood of neonates born from filaria infected mother are negatively associated with CD4+Tbet+ and CD4+RORγt+ T cells. [PDF]
PLoS ONE, 2014 BACKGROUND:Children who have been exposed in utero to maternal filarial infection are immunologically less responsive to filarial antigens, have less pathology, and are more susceptible to acquire infection than offspring of uninfected mothers.
Ulysse Ateba-Ngoa +9 more
doaj +1 more source
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity [PDF]
, 1987 We have shown in a murine model system for acute, lethal cytomegalovirus (CMV) disease in the immunocompromised natural host that control of virus multiplication in tissues, protection from virus-caused tissue destruction, and survival are mediated by ...
Reddehase, Matthias J. +4 more
core +1 more source
CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells
Nature Communications, 2022 CD4 and CD8 co-receptors are routinely used to define distinct functional and phenotypic lineages of T cells. Here the authors show CD4 and CD8 also modulate the functional avidity of the CD1b-restricted response to mycobacterial lipid ...
Charlotte A. James +11 more
doaj +1 more source
In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans
FEBS Open Bio, EarlyView.In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller +3 more
wiley +1 more source
Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination. [PDF]
, 2007 Mycobacterium bovis BCG is widely used as a vaccine against tuberculosis (TB), despite its variable protective efficacy. Relatively little is known about the immune response profiles following BCG vaccination in relation to protection against TB. Here we
Klein, Michèl R +12 more
core +1 more source