Results 51 to 60 of about 665,801 (300)
Identification of protective antigens for vaccination against systemic salmonellosis [PDF]
, 2014 There is an urgent medical need for improved vaccines with broad serovar coverage and high efficacy against systemic salmonellosis. Subunit vaccines offer excellent safety profiles but require identification of protective antigens, which remains a ...
Dirk eBumann +3 more
core +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Freeze-thaw lysates of Plasmodium falciparum-infected red blood cells induce differentiation of functionally competent regulatory T cells from memory T cells. [PDF]
, 2012 In addition to naturally occurring regulatory T (nTreg) cells derived from the thymus, functionally competent Treg cells can be induced in vitro from peripheral blood lymphocytes in response to TCR stimulation with cytokine costimulation.
Finney, Olivia C +11 more
core +1 more source
Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease
FEBS Letters, EarlyView.Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim +4 more
wiley +1 more source
Revista da Sociedade Brasileira de Medicina Tropical, 2013 Introduction CD4+CD25+ T lymphocytes have been implicated in the regulation of host inflammatory response against Trypanosoma cruzi, and may be involved in the clinical course of the disease.
Suellen Carvalho de Moura Braz +4 more
doaj +3 more sources
Molecular Therapy: OncologyCD4+ T helper antigens are essential components of cancer vaccines, but the relevance of the source of these MHC class II-restricted antigens remains underexplored. To compare the effectiveness of tumor-specific versus tumor-unrelated helper antigens, we
Joanna Fréderique de Graaf +12 more
doaj +1 more source
Flow Cytometric Analysis of T, B, and NK Cells Antigens in Patients with Mycosis Fungoides
Journal of Immunology Research, 2015 We retrospectively analyzed the clinicopathological correlation and prognostic value of cell surface antigens expressed by peripheral blood mononuclear cells in patients with mycosis fungoides (MF). 121 consecutive MF patients were included in this study.
Serkan Yazıcı +9 more
doaj +1 more source
Retrovirology, 2007 Background Expression levels of cell surface antigens such as CD38 and HLA-DR are related to HIV disease stages. To date, the immunophenotyping of cell surface antigens relies on flow cytometry, allowing estimation of 3–6 markers at a time.
Cunningham Anthony L +9 more
doaj +1 more source
Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance T-cell receptor recognition of antigen is an essential first step in the initiation of a T-cell response. This report demonstrates that CD4 T cells responding during an infection can discriminate between antigen affinity and antigen dose, resulting in distinct types of effector and memory cell generation. Moreover, memory
Keck, Simone +7 more
openaire +6 more sources
Endogenous human cytomegalovirus gB is efficiently presented by MHC class II molecules to CD4+ CTL [PDF]
, 2005 Human cytomegalovirus (HCMV) infects endothelial, epithelial, and glial cells in vivo. These cells can express MHC class II proteins, but are unlikely to play important roles in priming host immunity.
Nelson, JA +5 more
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