Results 51 to 60 of about 306,421 (309)

Antigen-armed antibodies targeting B lymphoma cells effectively activate antigen-specific CD4+ T cells [PDF]

Blood, 2015
Key PointsEpitopes in antigen-armed antibodies that target B-cell receptors are efficiently presented by B lymphoma cells to cytotoxic CD4+ T cells. Memory T cells activated by AgAbs ex vivo are able to kill targeted B lymphoma cells.
Yu, X., Ilecka, M., Bartlett, E.J., Schneidt, V., Bhat, R., Mautner, J., Feederle, R., Delecluse, H.J.   +7 more
openaire   +3 more sources

Expression of CCR6 on Helicobacter pylori-specific circulating CD4+ T cells

Инфекция и иммунитет
Introduction. Helicobacter pylori can infect human gastric mucosa and cause various pathological conditions. In the blood of H. pylori-infected patients, the level of mature CD4+CCR6+ T-lymphocytes, especially pro-inflammatory CCR6+ T-helper types 1 and ...
Vladimir Yu. Talayev, I. Ye. Zaichenko, M. V. Svetlova, E. V. Voronina, O. N. Babaykina, N. V. Neumoina, K. M. Perfilova   +6 more
doaj   +1 more source

Polyfunctional T cell responses in children in early stages of chronic Trypanosoma cruzi infection contrast with monofunctional responses of long-term infected adults [PDF]

, 2013
Background: Adults with chronic Trypanosoma cruzi exhibit a poorly functional T cell compartment, characterized by monofunctional (IFN-γ-only secreting) parasite-specific T cells and increased levels of terminally differentiated T cells.
Alejandro Armenti, Alicia Serjan, AN Akbar, Ana M. De Rissio, CL Day, D Sauce, Daniel Potente, DE Kaufmann, DE Perez-Mazliah, DM Vitelli-Avelar, E Kuschnir, Eric Dumonteil, GA Schmunis, GC Olivera, GL Bertocchi, Gonzalo Tomas, HW Virgin, J Hernández-Ruiz, J Nikolich-Zugich, JA Fiuza, JP Gigley, Laura E. Fichera, LMG Bahia-Oliveira, M Frentsch, M Samudio, María C. Albareda, María G. Alvarez, MC Albareda, MC Albareda, MC Albareda, MG Alvarez, MJ Yellin, Mónica I. Esteva, NS Joshi, PA Barrett, PA Darrah, PM Odorizzi, R Sathler-Avelar, R Viotti, RA Cutrullis, RA Seder, Rick L. Tarleton, RJ Arguello, RL Tarleton, Rodolfo Viotti, S Le Saux, S Sosa-Estani, S Vigano, SA Laucella, SA Laucella, SA Laucella, SM Henson, Susana A. Laucella, WO Dutra   +53 more
core   +3 more sources

Antigen-Dependent and Antigen-Independent Pathways Modulate CD4 ⁺ CD28 ^null T-Cells During Atherosclerosis [PDF]

Circulation Research, 2012
To the Editor: We read with interest the article by Dumitriu et al1 that characterized the alternative costimulatory pathways of CD4+CD28null T cells, a terminally differentiated effector T-cell population, in patients with acute coronary syndromes (ACS).
E. Ammirati, C. Monaco, G.D. Norata
openaire   +5 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Fighting viral infections and virus-driven tumors with cytotoxic CD4+ T cells [PDF]

, 2017
CD4+ T cells have been and are still largely regarded as the orchestrators of immune responses, being able to differentiate into distinct T helper cell populations based on differentiation signals, transcription factor expression, cytokine secretion, and
Adhikary, Adhikary, Adhikary, Ahn, Anderson, Annunziato, Appay, Appay, Aslan, Balfour, Battaglia, Baumjohann, Bickham, Bosselut, Britt, Brown, Brown, Brown, Brown, Brown, Bui, Cao, Cao, Cao, Carpenter, Casazza, Chen, Cheroutre, Chiu, Coler, de Souza, Deligeoroglou, Demachi-Okamura, Depil, Devarajan, Di Mitri, Dillon, Draenert, Duftner, Dumitriu, Endo, Enssle, Eshima, Facchinetti, Farrar, Faè, Fishman, Fleischer, Fontenot, Freeman, Fu, Fu, Gamadia, Gao, Garcia-Chagollan, Gasser, Geginat, Gelband, Goonetilleke, Grabowska, Grakoui, Grant, Grant, Groh, Ha, Haigh, Haque, Heaton, Hegde, Heller, Heusinkveld, Hildemann, Hislop, Hohler, Homma, Houser, Hua, Huz, Icheva, James, Jameson, Jeitziner, Johnson, Jones, Jones, Jonjic, Kadish, Kannanganat, Kaufmann, Kayagaki, Kenter, Kenter, Khanolkar, King, King, Kobayashi, Koel, Krensky, Kroesen, Kruger, Kuroda, Lazdina, Li, Libri, Lin, Loewendorf, Long, Long, Long, Long, Luckheeram, Lunemann, MacArthur, Mackay, Magnani, Malnati, Man, Manzke, Marshall, Martorelli, Mattapallil, McKinstry, McMichael, Merlo, Merlo, Metkar, Miamen, Moormann, Morales, Mosmann, Mucida, Munz, Munz, Murphy, Musey, Namekawa, Nemes, Nikiforow, Nixon, Norris, Oestreich, Omiya, O’Shea, Pachnio, Pachnio, Paludan, Pender, Peng, Penna, Piriou, Plata, Porakishvili, Qui, Quigley, Ratto-Kim, Reis, Rentenaar, Rerks-Ngarm, Ressing, Rosenberg, Sacha, Sakaguchi, Sallusto, Sandbulte, Savic, Scherrenburg, Schueller, Schulze zur Wiesch, Schulze Zur Wiesch, Schwartz, Seresini, Seresini, Soghoian, Soghoian, Spaete, Stacey, Steele, Streeck, Stuller, Su, Sun, Tagawa, Takeuchi, Tenzer, Terahara, Tewari, Thursz, Todryk, Tong, Toussirot, Trautmann, Trautmann, Trifari, Tscharke, Turnbull, Ulsenheimer, Vacchio, van de Berg, van den Hende, van Leeuwen, Vasin, Veldhoen, Ventura, Verma, Veronese, Voo, Voo, Vossen, Walker, Walton, Wang, Wang, Welters, Welters, WHO, Wilkinson, Wilson, Wilson, Wintermeyer, Workman, Xie, Xue, Yan, Yewdell, Zaunders, Zaunders, Zheng, Zhou, Zuo, zur Hausen   +229 more
core   +2 more sources

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Neoantigen-specific T cell help outperforms non-specific help in multi-antigen DNA vaccination against cancer

Molecular Therapy: Oncology
CD4+ T helper antigens are essential components of cancer vaccines, but the relevance of the source of these MHC class II-restricted antigens remains underexplored. To compare the effectiveness of tumor-specific versus tumor-unrelated helper antigens, we
Joanna Fréderique de Graaf, Tamara Pesic, Felicia S. Spitzer, Koen Oosterhuis, Marcel G.M. Camps, Iris Zoutendijk, Bram Teunisse, Wahwah Zhu, Tsolere Arakelian, Gerben C. Zondag, Ramon Arens, Jeroen van Bergen, Ferry Ossendorp   +12 more
doaj   +1 more source

Immunogenicity of targeted lentivectors [PDF]

, 2014
To increase the safety and possibly efficacy of HIV-1 derived lentivectors (LVs) as an anti-cancer vaccine, we recently developed the Nanobody (Nb) display technology to target LVs to antigen presenting cells (APCs).
Adotévi, Bennett, Bevan, Bhardwaj, Bhardwaj, Bhardwaj, Blander, Bonehill, Bonehill, Breckpot, Breckpot, Breckpot, Charleston, Chuah, Collins, Collins, Collins, Collins, Cosset, Diebold, Donckier, Eggermont, Enk, Figdor, Gajewski, Garcia, Groettrup, Inaba, Kast, Lahoutte, Lévy, McCullough, Medzhitov, Melief, Mellman, Mortha, Moser, Moser, Munn, Naldini, Neyns, Noguiez-Hellin, Nussenzweig, Palena, Raes, Reis e Sousa, Reiser, Reiser, Richardson, Romani, Roncarolo, Sakuma, Schroyens, Semesyuk, Song, Storm, Thielemans, Thielemans, Thielemans, Thielemans, Torretta, Turk, Van Kooyk, Wang, Wang, Yamaguchi, Yewdell, Yu   +67 more
core   +3 more sources

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source