Results 31 to 40 of about 221,142 (316)

The Effect of a Linear Tuning between the Antigenic Stimulations of CD4+ T Cells and CD4+ Tregs [PDF]

Mathematics, 2020
We study the equilibria of an Ordinary Differencial Equation (ODE) system where CD4 + effector or helper T cells and Regulatory T cells (Tregs) are present. T cells trigger an immune response in the presence of their specific antigen. Regulatory T cells (Tregs) play a role in limiting auto-immune diseases due to their immune-suppressive ability.
Aliyu Yusuf, Isabel Figueiredo, Atefeh Afsar, Nigel Burroughs, Alberto Pinto, Bruno Oliveira   +5 more
openaire   +4 more sources

Tracking Virus-Specific CD4+ T Cells during and after Acute Hepatitis C Virus Infection [PDF]

, 2007
Background. CD4+ T cell help is critical in maintaining antiviral immune responses and such help has been shown to be sustained in acute resolving hepatitis C.
Paul Klenerman, GRÜNER N, Thimme, R., J. Tilman Gerlach, Weber, Jonathan N., Ulsenheimer, Axel, Helmut M. Diepolder, PFAFFEROT K, Semmo, N, Scriba, Thomas J, Silvana Gaudieri, Hans Nitschko, Grüner Norbert, SANTANTONIO, TERESA ANTONIA, Haberstroh, Anita, Diepolder Helmut M., Pfafferot, Katja, Jung, Maria-Christina, Rauch, A, Norbert Grüner, Andri Rauch, Scriba, T.J., Obermeier, M., Diepolder, HM, Pape Gerd R., Jonathan N Weber, Gaudieri Silvana, Malte H. J. Heeg, OBERMEIER M, Anita Haberstroh, SCHRAUT W, Jung, M-C, Gerd R Pape, Michaela Lucas, FIDLER S, RAUCH A, DAY C, Phillips, Rodney, Malte H.J. Heeg, Gaudieri, S., Maria-Christina Jung, Thimme Robert, Pape, Gerd R., Obermeier, Martin, Obermeier Martin, Day Cheryl, Obermeier, M, Rodney Phillips, Klenerman Paul, Heeg, MH, Martin Obermeier, Haberstroh, A., Day, C., Klenerman, Paul, Grüner, Norbert, Zachoval, R., Thimme, Robert, Baumert, Thomas F., Phillips, R., Gerlach, JT, Haberstroh Anita, Gerlach, J Tilman, Klenerman, P, Santantonio, T., ZACHOVAL R, Ulsenheimer, A., Nitschko, Hans, Lucas, Michaela, Nasser Semmo, Zachoval Reinhart, KLENERMAN P, Weber, J.N., Baumert Thomas F., Bowyer, S., Fidler, Sarah, Phillips Rodney, Haberstroh, A, Heeg Malte H.J., ULSENHEIMER A, Thomas F. Baumert, Baumert, TF, Diepolder, Helmut M, Axel Ulsenheimer, Thomas F Baumert, Gruener, N, Pfafferot, K, Pape, GR, Helmut M Diepolder, BAUMERT TF, Winfried Schraut, Jung, M.C., Zachoval, R, Gerlach, J.T., Thimme, R, Phillips, R, LUCAS M, Semmo, N., Heeg, Malte H. J., Semmo Nasser, HEEG MH, Gerlach J. Tilman, Nitschko Hans, HABERSTROH A, Santantonio Teresa, Robert Thimme, Grüner, N., Santantonio, T, Schraut Winfried, Klenerman, P., Pape, Gerd R, J. Tilman, Santantonio, Teresa, Scriba, Thomas J., Nitschko, H., Jung, MC, Jonathan N. Weber, Reinhart Zachoval, Scriba, TJ, NITSCHKO H, Lucas, M., Katja Pfafferot, Jung Maria-Christina, Fidler, S., Heeg, M., Schraut, Winfried, Malte H J Heeg, J Tilman Gerlach, Pfafferot Katja, Weber Jonathan N., Diepolder, H.M., Baumert, T.F., Gaudieri, S, Cheryl Day, GAUDIERI S, PAPE GR, Lucas, M, Fidler Sarah, WEBER JN, DIEPOLDER HM, Weber, Jonathan N, Schraut, W., Day, C, Ulsenheimer, A, Gerlach, J. Tilman, SEMMO N, Thomas J Scriba, Ulsenheimer Axel, Day, Cheryl, Lucas Michaela, PHILLIPS R, Diepolder, Helmut M., Pfafferott, K., Heeg, MHJ, Fidler, S, Rauch, A., Thomas J. Scriba, GERLACH JT, Gruner, N, Nitschko, H, Heeg, Malte H J, Gerd R. Pape, Sarah Fidler, Rauch Andri, Rauch, Andri, Baumert, Thomas F, Scriba Thomas J., Pape, G.R., Schraut, W, THIMME R, Semmo, Nasser, Weber, JN, JUNG MC, Teresa Santantonio, Gaudieri, Silvana, Zachoval, Reinhart, SCRIBA TJ   +175 more
core   +1 more source

Decreased memory T-cell response and function in human immunodeficiency virus-infected patients with tegumentary leishmaniasis

Memorias do Instituto Oswaldo Cruz, 2014
The effects of human immunodeficiency virus (HIV) on the immune response in patients with cutaneous leishmaniasis have not yet been fully delineated.
Luana Leandro Gois, Sanjay Mehta, Maria Zilma Andrade Rodrigues, Robert T Schooley, Roberto Badaro, Maria Fernanda Rios Grassi   +5 more
doaj   +1 more source

CD4+CD25hiFOXP3+ cells in cord blood of neonates born from filaria infected mother are negatively associated with CD4+Tbet+ and CD4+RORγt+ T cells. [PDF]

PLoS ONE, 2014
BACKGROUND:Children who have been exposed in utero to maternal filarial infection are immunologically less responsive to filarial antigens, have less pathology, and are more susceptible to acquire infection than offspring of uninfected mothers.
Ulysse Ateba-Ngoa, Ghyslain Mombo-Ngoma, Eva Zettlmeissl, Luciën E P M van der Vlugt, Sanne E de Jong, Pierre-Blaise Matsiegui, Michael Ramharter, Peter G Kremsner, Maria Yazdanbakhsh, Ayola Akim Adegnika   +9 more
doaj   +1 more source

Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses [PDF]

, 2008
Alum is used as a vaccine adjuvant and induces T_h2 responses and T_h2-driven antibody isotype production against co-injected antigens.
White, Janice, Kappler, John W., McKee, Amy S., Marrack, Philippa, Macleod, Megan, P. Marrack, J. White, J. W. Kappler, F. Crawford, A. S. McKee, M. MacLeod, Crawford, Frances   +11 more
core   +1 more source

Sézary Syndrome with CD4/CD8 Double-Negative Neoplastic T Cells in Peripheral Blood

Case Reports in Hematology, 2021
Sézary syndrome is a rare leukemic type of cutaneous T-cell lymphoma characterized by the presence of neoplastic T cells with cerebriform nuclei (Sézary cells) in the skin, lymph nodes, and peripheral blood.
Yuki Kageyama, Kenshiro Tsuda, Yuma Nato, Keiki Nagaharu, Kazutaka Suzuki, Akihiko Sawaki, Hiroyuki Miyashita   +6 more
doaj   +1 more source

Secretory Microneme Proteins Induce T-Cell Recall Responses in Mice Chronically Infected with Toxoplasma gondii

mSphere, 2019
Microneme (MIC) proteins play important roles in the recognition, adhesion, and invasion of host cells by Toxoplasma gondii. Previous studies have shown that MIC proteins are highly immunogenic in the mouse and recognized by human serum antibodies.
Iti Saraav, Qiuling Wang, Kevin M. Brown, L. David Sibley   +3 more
doaj   +1 more source

Intratumor childhood vaccine-specific CD4+ T-cell recall coordinates antitumor CD8+ T cells and eosinophils

Journal for ImmunoTherapy of Cancer, 2023
Background Antitumor mechanisms of CD4+ T cells remain crudely defined, and means to effectively harness CD4+ T-cell help for cancer immunotherapy are lacking. Pre-existing memory CD4+ T cells hold potential to be leveraged for this purpose.
Daniel Landi, Annick Desjardins, Matthias Gromeier, Darell D Bigner, Smita K Nair, Michael C Brown, Georgia M Beasley, David M Ashley, Yuanfan Yang, Zachary P McKay, Dina M Randazzo   +10 more
doaj   +1 more source

CD4+CD25+ TR cells suppress innate immune pathology through cytokine-dependent mechanisms [PDF]

, 2003
Copyright @ 2003 The Rockefeller University PressCD4+CD25+ regulatory T (TR) cells can inhibit a variety of autoimmune and inflammatory diseases, but the precise mechanisms by which they suppress immune responses in vivo remain unresolved.
Maloy, Kevin, Fiona Powrie, Maloy, Kevin J., Gordon Dougan, Powrie, Fiona, Dougan, Gordon, Saunders, Nigel, Laurence Salaun, Cahill, R, Saunders, NJ, Saunders, Nigel J., Nigel J. Saunders, Salaun, L, Powrie, F, Rachel Cahill, Kevin J. Maloy, Salaun, Laurence, Maloy, KJ, Dougan, G, Cahill, Rachel   +19 more
core   +1 more source

Production of Proinflammatory Cytokines by CD4+ and CD8+ T Cells in Response to Mycobacterial Antigens among Children and Adults with Tuberculosis

Pathogens, 2023
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of pediatric morbidity and mortality. Young children are at high risk of TB following Mtb exposure, and this vulnerability is secondary to insufficient host immunity ...
Erin Morrow, Qijia Liu, Sarah Kiguli, Gwendolyn Swarbrick, Mary Nsereko, Megan D. Null, Meghan Cansler, Harriet Mayanja-Kizza, W. Henry Boom, Phalkun Chheng, Melissa R. Nyendak, David M. Lewinsohn, Deborah A. Lewinsohn, Christina L. Lancioni   +13 more
doaj   +1 more source