Results 11 to 20 of about 211,397 (266)

Virus and autoantigen-specific CD4+ T cells are key effectors in a SCID mouse model of EBV-associated post-transplant lymphoproliferative disorders. [PDF]

PLoS Pathogens, 2014
Polyclonal Epstein-Barr virus (EBV)-infected B cell line (lymphoblastoid cell lines; LCL)-stimulated T-cell preparations have been successfully used to treat EBV-positive post-transplant lymphoproliferative disorders (PTLD) in transplant recipients, but ...
Stefanie Linnerbauer, Uta Behrends, Dinesh Adhikary, Klaus Witter, Georg W Bornkamm, Josef Mautner   +5 more
doaj   +1 more source

New perspective on dextran sodium sulfate colitis: antigen-specific T cell development during intestinal inflammation. [PDF]

PLoS ONE, 2013
CD4+ T cell responses against oral antigens can develop in inflammatory bowel disease (IBD) patients, which may modulate disease. Dextran sodium sulfate (DSS) colitis is commonly used to study IBD, however, it is not considered the best model in which to
Mary E Morgan, Bin Zheng, Pim J Koelink, Hendrick J G van de Kant, Lizette C J M Haazen, Manon van Roest, Johan Garssen, Gert Folkerts, Aletta D Kraneveld   +8 more
doaj   +1 more source

The dysfunction of CD4(+)CD25(+) regulatory T cells contributes to the abortion of mice caused by Toxoplasma gondii excreted-secreted antigens in early pregnancy.

PLoS ONE, 2013
Toxoplasma gondii is an opportunistic intracellular parasite that is highly prevalent in human and warm-blooded animals throughout the world, leading to potentially severe congenital infections. Although the abortion caused by T. gondii is believed to be
Jin-ling Chen, Yi-yue Ge, Jie Zhang, Xiao-yan Qiu, Jing-fan Qiu, Jiang-ping Wu, Yong Wang   +6 more
doaj   +1 more source

Epitopes of the CD4 Antigen and HIV Infection

Science, 1986
The CD4 (or T4) surface antigen of human T lymphocytes is an important part of the receptor for the human immunodeficiency virus (HIV). After binding to the receptor, the HIV may enter the T cell and induce the formation of syncytia. In an attempt to identify the receptor site more closely, monoclonal antibodies (Mab's) to CD4 were tested ...
Sattentau, Q, Dalgleish, A, Weiss, R, Beverley, P   +3 more
openaire   +3 more sources

Dynamic Adoption of Anergy by Antigen-Exhausted CD4+ T Cells [PDF]

The Journal of Immunology, 2021
Abstract Exhausted immune responses to chronic diseases represent a major challenge to global health. To explore their cell fate and plasticity in exhaustion, we analyzed CD4+T cells in a mouse model with regulatable antigen presentation.
Trefzer, A., Kadam, P., Wang, S.H., Pennavaria, S., Lober, B., Akçabozan, B., Kranich, J., Brocker, T., Nakano, N., Irmler, M., Beckers, J., Straub, T., Obst, R.   +12 more
openaire   +4 more sources

Mycobacterial antigens in pleural fluid mononuclear cells to diagnose pleural tuberculosis in HIV co-infected patients

BMC Infectious Diseases, 2020
Background Extra pulmonary manifestation of tuberculosis (TB) accounts for approximately one-half of TB cases in HIV-infected individuals with pleural TB as the second most common location. Even though mycobacteria are cleared, mycobacterial antigens may
Tehmina Mustafa, Ida Wergeland, Kamaldeen Baba, Sharad Pathak, Anwar A. Hoosen, Anne Margarita Dyrhol-Riise   +5 more
doaj   +1 more source

Immunity to intracellular Salmonella depends on surface-associated antigens. [PDF]

PLoS Pathogens, 2012
Invasive Salmonella infection is an important health problem that is worsening because of rising antimicrobial resistance and changing Salmonella serovar spectrum.
Somedutta Barat, Yvonne Willer, Konstantin Rizos, Beatrice Claudi, Alain Mazé, Anne K Schemmer, Dennis Kirchhoff, Alexander Schmidt, Neil Burton, Dirk Bumann   +9 more
doaj   +1 more source

CD4 T cells and their antigens in the pathogenesis of autoimmune diabetes [PDF]

Current Opinion in Immunology, 2011
Pathogenesis of type 1 diabetes (T1D) is mediated by effector T cells and CD4 Th1 and Th17T cells have important roles in this process. While effector function of Th1 cells is well established, because of their inherent plasticity Th17 cells have been more controversial.
Kathryn, Haskins, Anne, Cooke
openaire   +2 more sources

The Effect of a Linear Tuning between the Antigenic Stimulations of CD4+ T Cells and CD4+ Tregs [PDF]

Mathematics, 2020
We study the equilibria of an Ordinary Differencial Equation (ODE) system where CD4 + effector or helper T cells and Regulatory T cells (Tregs) are present. T cells trigger an immune response in the presence of their specific antigen. Regulatory T cells (Tregs) play a role in limiting auto-immune diseases due to their immune-suppressive ability.
Aliyu Yusuf, Isabel Figueiredo, Atefeh Afsar, Nigel Burroughs, Alberto Pinto, Bruno Oliveira   +5 more
openaire   +4 more sources

Synergy between CD8 T cells and Th1 or Th2 polarised CD4 T cells for adoptive immunotherapy of brain tumours. [PDF]

PLoS ONE, 2013
The feasibility of cancer immunotherapy mediated by T lymphocytes is now a clinical reality. Indeed, many tumour associated antigens have been identified for cytotoxic CD8 T cells, which are believed to be key mediators of tumour rejection.
Sabine Hoepner, Jacelyn M S Loh, Cristina Riccadonna, Madiha Derouazi, Céline Yacoub Maroun, Pierre-Yves Dietrich, Paul R Walker   +6 more
doaj   +1 more source