Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells [PDF]
Journal of Experimental Medicine, 2012 Dendritic cells (DCs) can initiate and shape host immune responses toward either immunity or tolerance by their effects on antigen-specific CD4(+) T cells.
Akira +66 more
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Blastic plasmacytoid dendritic cell neoplasm [PDF]
Anais Brasileiros de Dermatologia, 2013 Blastic plasmacytoid dendritic cell neoplasm is a rare and aggressive hematodermic neoplasia with frequent cutaneous involvement and leukemic dissemination.
André Lencastre +5 more
doaj +1 more source
To respond or not to respond - a personal perspective of intestinal tolerance [PDF]
, 2018 For many years, the intestine was one of the poor relations of the immunology world, being a realm inhabited mostly by specialists and those interested in unusual phenomena.
A Besredka +142 more
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Virus and autoantigen-specific CD4+ T cells are key effectors in a SCID mouse model of EBV-associated post-transplant lymphoproliferative disorders. [PDF]
PLoS Pathogens, 2014 Polyclonal Epstein-Barr virus (EBV)-infected B cell line (lymphoblastoid cell lines; LCL)-stimulated T-cell preparations have been successfully used to treat EBV-positive post-transplant lymphoproliferative disorders (PTLD) in transplant recipients, but ...
Stefanie Linnerbauer +5 more
doaj +1 more source
CD4+ T-cell epitope prediction using antigen processing constraints [PDF]
Journal of Immunological Methods, 2016 T-cell CD4+ epitopes are important targets of immunity against infectious diseases and cancer. State-of-the-art methods for MHC class II epitope prediction rely on supervised learning methods in which an implicit or explicit model of sequence specificity is constructed using a training set of peptides with experimentally tested MHC class II binding ...
Ramgopal R, Mettu +2 more
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New perspective on dextran sodium sulfate colitis: antigen-specific T cell development during intestinal inflammation. [PDF]
PLoS ONE, 2013 CD4+ T cell responses against oral antigens can develop in inflammatory bowel disease (IBD) patients, which may modulate disease. Dextran sodium sulfate (DSS) colitis is commonly used to study IBD, however, it is not considered the best model in which to
Mary E Morgan +8 more
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Controversies concerning thymus-derived regulatory T cells: fundamental issues and a new perspective [PDF]
, 2015 Thymus-derived regulatory T cells (Tregs) are considered to be a distinct T-cell lineage that is genetically programmed and specialised for immunosuppression.
Ono, M, Tanaka, RJ
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PLoS ONE, 2013 Toxoplasma gondii is an opportunistic intracellular parasite that is highly prevalent in human and warm-blooded animals throughout the world, leading to potentially severe congenital infections. Although the abortion caused by T. gondii is believed to be
Jin-ling Chen +6 more
doaj +1 more source
Simultaneous expression of CD4 and CD8 antigens by a substantial proportion of resting porcine T lymphocytes [PDF]
, 1987 The existence of four subpopulations in resting porcine T lymphocytes is documented. In addition to the two known subpopulations which are typified by a mutually exclusive expression of either the CD8 or the CD4 differentiation antigen, CD4-CD8+ and CD4 ...
Bevan +19 more
core +3 more sources
BMC Infectious Diseases, 2020 Background Extra pulmonary manifestation of tuberculosis (TB) accounts for approximately one-half of TB cases in HIV-infected individuals with pleural TB as the second most common location. Even though mycobacteria are cleared, mycobacterial antigens may
Tehmina Mustafa +5 more
doaj +1 more source