Results 11 to 20 of about 221,142 (316)
Immunodominance of lytic cycle antigens in Epstein-Barr virus-specific CD4+ T cell preparations for therapy. [PDF]
PLoS ONE, 2007 BackgroundEpstein-Barr virus (EBV) is associated with a number of human malignancies. EBV-positive post-transplant lymphoproliferative disease in solid organ and hematopoietic stem cell transplant recipients has been successfully treated by the adoptive ...
Dinesh Adhikary +8 more
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Frontiers in Cellular and Infection Microbiology, 2021 Cysticercus cellulosae (C. cellulosae) excretes and secretes antigens during the parasitic process to regulate the host immune response; however, resulting immune response and cytokine production in the host during infection still remains unclear.
Xianmin Fan +10 more
doaj +1 more source
Frontiers in Immunology, 2022 Mycobacterium tuberculosis infection is generally asymptomatic as latent tuberculosis, but it is still known as the world’s leading bacterial cause of death.
Yong-Hun Lee +11 more
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Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinct
OncoImmunology, 2022 Tumor-specific T cells likely underpin effective immune checkpoint-blockade therapies. Yet, most studies focus on Treg cells and CD8+ tumor-infiltrating lymphocytes (TILs).
Shamin Li +10 more
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Identification of CD4+ T cell epitopes in C. burnetii antigens targeted by antibody responses. [PDF]
PLoS ONE, 2011 Coxiella burnetii is an obligate intracellular gram-negative bacterium that causes acute Q fever and chronic infections in humans. A killed, whole cell vaccine is efficacious, but vaccination can result in severe local or systemic adverse reactions ...
Chen Chen +7 more
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Antigens for CD4 and CD8 T Cells in Tuberculosis [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (MTB), represents an important cause of morbidity and mortality worldwide for which an improved vaccine and immunodiagnostics are urgently needed. CD4(+) and CD8(+) T cells play an important role in host defense to TB.
Cecilia S, Lindestam Arlehamn +3 more
openaire +2 more sources
Screening of human tumor antigens for CD4 T cell epitopes by combination of HLA-transgenic mice, recombinant adenovirus and antigen peptide libraries. [PDF]
PLoS ONE, 2010 BACKGROUND: As tumor antigen-specific CD4+ T cells can mediate strong therapeutic anti-tumor responses in melanoma patients we set out to establish a comprehensive screening strategy for the identification of tumor-specific CD4+ T cell epitopes suitable ...
Wolfram Osen +9 more
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Frontiers in Immunology, 2022 CD4+ T cell responses to self-antigens are pivotal for immunological self-tolerance. Activation of Foxp3– T-conventional (T-conv) cells can precipitate autoimmune disease, whereas activation of Foxp3+ T-regulatory (T-reg) cells is essential to prevent ...
Chenglong Wang, Stephen R. Daley
doaj +1 more source
Blastic plasmacytoid dendritic cell neoplasm [PDF]
Anais Brasileiros de Dermatologia, 2013 Blastic plasmacytoid dendritic cell neoplasm is a rare and aggressive hematodermic neoplasia with frequent cutaneous involvement and leukemic dissemination.
André Lencastre +5 more
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Dynamic Adoption of Anergy by Antigen-Exhausted CD4+ T Cells [PDF]
The Journal of Immunology, 2021 Abstract Exhausted immune responses to chronic diseases represent a major challenge to global health. To explore their cell fate and plasticity in exhaustion, we analyzed CD4+T cells in a mouse model with regulatable antigen presentation.
Trefzer, A. +12 more
openaire +4 more sources