Results 1 to 10 of about 665,801 (300)

Immunopeptidomics reveals conserved and abundant Francisella tularensis proteins as immunogenic CD4 T cell antigens in mice. [PDF]

PLoS Pathogens
Human tularemia is caused by infection with the intracellular bacterium Francisella tularensis. The ability of the bacterium to cause a severe pneumonic form of the disease has led to concerns in the field of biodefense and efforts to develop a vaccine ...
Pavlina Laskova, Stanislava Porkertova, Ondrej Ballek, Lucie Balonova, Jana Pavloskova, Ales Neuwirth, Ivona Pavkova, Ivo Fabrik, Pavol Lukac, Luca Vannucci, Dominik Filipp, Jiri Stulik, Marek Link   +12 more
doaj   +2 more sources

A Mycobacterium tuberculosis rare variable antigen vaccine reduces lung pathology in hypersusceptible SP140−/− mice [PDF]

Frontiers in Tuberculosis
Mycobacterium tuberculosis is the leading cause of death globally due to a single infectious agent. Currently, no licensed vaccine protects against pulmonary tuberculosis, the primary adult disease caused by Mtb infection.
Zachary P. Howard, Alexander Mohapatra, Weihao Zheng, Joel D. Ernst   +3 more
doaj   +2 more sources

Multi-antigen coronavirus vaccine induces potent and durable cross-protection against multiple SARS-CoV-2 variants [PDF]

npj Vaccines
The first-generation Spike-based COVID-19 vaccines reduced the risk of hospitalization, serious illness, and death from SARS-CoV-2 infections. However, waning immunity failed to prevent immune escape, resulting in multiple variants of concern (VOCs) and ...
Swayam Prakash, Nisha R. Dhanushkodi, Afshana Quadiri, Hawa Vahed, Aziz A. Chentoufi, Pierre-Gregoire Coulon, Izabela Coimbra Ibraim, Assia El Babsiri, Delia F. Tifrea, Cesar J. Figueroa, Daniel Gil, Jeffrey B. Ulmer, Lbachir BenMohamed   +12 more
doaj   +2 more sources

Cysticercus cellulosae Regulates T-Cell Responses and Interacts With the Host Immune System by Excreting and Secreting Antigens

Frontiers in Cellular and Infection Microbiology, 2021
Cysticercus cellulosae (C. cellulosae) excretes and secretes antigens during the parasitic process to regulate the host immune response; however, resulting immune response and cytokine production in the host during infection still remains unclear.
Xianmin Fan, Yue Zhang, Renhui Ouyang, Bo Luo, Lizhu Li, Wei He, Meichen Liu, Nan Jiang, Fengjiao Yang, Lingjun Wang, Biying Zhou   +10 more
doaj   +1 more source

Identification of CD4+ T cell epitopes in C. burnetii antigens targeted by antibody responses. [PDF]

PLoS ONE, 2011
Coxiella burnetii is an obligate intracellular gram-negative bacterium that causes acute Q fever and chronic infections in humans. A killed, whole cell vaccine is efficacious, but vaccination can result in severe local or systemic adverse reactions ...
Chen Chen, Courtney Dow, Peng Wang, John Sidney, Amanda Read, Allen Harmsen, James E Samuel, Bjoern Peters   +7 more
doaj   +1 more source

Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinct

OncoImmunology, 2022
Tumor-specific T cells likely underpin effective immune checkpoint-blockade therapies. Yet, most studies focus on Treg cells and CD8+ tumor-infiltrating lymphocytes (TILs).
Shamin Li, Summer Zhuang, Antja Heit, Si-Lin Koo, Aaron C. Tan, I-Ting Chow, William W. Kwok, Iain Beehuat Tan, Daniel S.W. Tan, Yannick Simoni, Evan W. Newell   +10 more
doaj   +1 more source

Comprehensive analysis of mycobacterium tuberculosis antigen-specific CD4+ T cell responses restricted by single HLA class II allotype in an individual

Frontiers in Immunology, 2022
Mycobacterium tuberculosis infection is generally asymptomatic as latent tuberculosis, but it is still known as the world’s leading bacterial cause of death.
Yong-Hun Lee, Yong-Hun Lee, You-Seok Hyun, You-Seok Hyun, Hyeong-A Jo, Hyeong-A Jo, In-Cheol Baek, Sun-Mi Kim, Hyun-Jung Sohn, Tai-Gyu Kim, Tai-Gyu Kim, Tai-Gyu Kim   +11 more
doaj   +1 more source

Screening of human tumor antigens for CD4 T cell epitopes by combination of HLA-transgenic mice, recombinant adenovirus and antigen peptide libraries. [PDF]

PLoS ONE, 2010
BACKGROUND: As tumor antigen-specific CD4+ T cells can mediate strong therapeutic anti-tumor responses in melanoma patients we set out to establish a comprehensive screening strategy for the identification of tumor-specific CD4+ T cell epitopes suitable ...
Wolfram Osen, Sabine Soltek, Mingxia Song, Barbara Leuchs, Julia Steitz, Thomas Tüting, Stefan B Eichmüller, Xuan-Duc Nguyen, Dirk Schadendorf, Annette Paschen   +9 more
doaj   +1 more source

CD4+ T Cells of Prostate Cancer Patients Have Decreased Immune Responses to Antigens Derived From SARS-CoV-2 Spike Glycoprotein

Frontiers in Immunology, 2021
The adaptive immune response to severe acute respiratory coronavirus 2 (SARS-CoV-2) is important for vaccine development and in the recovery from coronavirus disease 2019 (COVID-19).
Pavla Taborska, Zuzana Strizova, Dmitry Stakheev, Ludek Sojka, Ludek Sojka, Jirina Bartunkova, Daniel Smrz   +6 more
doaj   +1 more source

A lentiviral vector encoding fusion of light invariant chain and mycobacterial antigens induces protective CD4+ T cell immunity

Cell Reports, 2022
Summary: Lentiviral vectors (LVs) are highly efficient at inducing CD8+ T cell responses. However, LV-encoded antigens are processed inside the cytosol of antigen-presenting cells, which does not directly communicate with the endosomal major ...
Jodie Lopez, François Anna, Pierre Authié, Alexandre Pawlik, Min-Wen Ku, Catherine Blanc, Philippe Souque, Fanny Moncoq, Amandine Noirat, David Hardy, Wladimir Sougakoff, Roland Brosch, Françoise Guinet, Pierre Charneau, Laleh Majlessi   +14 more
doaj   +1 more source