Results 1 to 10 of about 211,397 (266)

Rare variable M. tuberculosis antigens induce predominant Th17 responses in human infection [PDF]

JCI Insight
CD4 T cells are essential for immunity to M tuberculosis (Mtb), and emerging evidence indicates that IL-17–producing Th17 cells contribute to immunity to Mtb.
Paul Ogongo, Liya Wassie, Anthony Tran, Devin Columbus, Julia Huffaker, Lisa Sharling, Gregory Ouma, Samuel Gurrion Ouma, Kidist Bobosha, Cecilia S. Lindestam Arlehamn, Neel R. Gandhi, Sara C. Auld, Jyothi Rengarajan, Cheryl L. Day, Artur Queiroz, Mariana Araújo-Pereira, Eduardo Fukutani, Bruno B. Andrade, John D. Altman, Henry M. Blumberg, Joel D. Ernst, the TBRU ASTRa Study Group   +21 more
doaj   +2 more sources

Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses

Nature Communications, 2017
Antigen presentation is generally considered the domain of innate immune cells, but CD4+ T cells can transphagocytose bacteria from infected dendritic cells.
FRANCISCO Sanchez-Madrid, Aranzazu Cruz ADÁLIA, Balbino Alarcon   +2 more
exaly   +2 more sources

Cysticercus cellulosae Regulates T-Cell Responses and Interacts With the Host Immune System by Excreting and Secreting Antigens

Frontiers in Cellular and Infection Microbiology, 2021
Cysticercus cellulosae (C. cellulosae) excretes and secretes antigens during the parasitic process to regulate the host immune response; however, resulting immune response and cytokine production in the host during infection still remains unclear.
Xianmin Fan, Yue Zhang, Renhui Ouyang, Bo Luo, Lizhu Li, Wei He, Meichen Liu, Nan Jiang, Fengjiao Yang, Lingjun Wang, Biying Zhou   +10 more
doaj   +1 more source

Comprehensive analysis of mycobacterium tuberculosis antigen-specific CD4+ T cell responses restricted by single HLA class II allotype in an individual

Frontiers in Immunology, 2022
Mycobacterium tuberculosis infection is generally asymptomatic as latent tuberculosis, but it is still known as the world’s leading bacterial cause of death.
Yong-Hun Lee, Yong-Hun Lee, You-Seok Hyun, You-Seok Hyun, Hyeong-A Jo, Hyeong-A Jo, In-Cheol Baek, Sun-Mi Kim, Hyun-Jung Sohn, Tai-Gyu Kim, Tai-Gyu Kim, Tai-Gyu Kim   +11 more
doaj   +1 more source

Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinct

OncoImmunology, 2022
Tumor-specific T cells likely underpin effective immune checkpoint-blockade therapies. Yet, most studies focus on Treg cells and CD8+ tumor-infiltrating lymphocytes (TILs).
Shamin Li, Summer Zhuang, Antja Heit, Si-Lin Koo, Aaron C. Tan, I-Ting Chow, William W. Kwok, Iain Beehuat Tan, Daniel S.W. Tan, Yannick Simoni, Evan W. Newell   +10 more
doaj   +1 more source

Identification of CD4+ T cell epitopes in C. burnetii antigens targeted by antibody responses. [PDF]

PLoS ONE, 2011
Coxiella burnetii is an obligate intracellular gram-negative bacterium that causes acute Q fever and chronic infections in humans. A killed, whole cell vaccine is efficacious, but vaccination can result in severe local or systemic adverse reactions ...
Chen Chen, Courtney Dow, Peng Wang, John Sidney, Amanda Read, Allen Harmsen, James E Samuel, Bjoern Peters   +7 more
doaj   +1 more source

Screening of human tumor antigens for CD4 T cell epitopes by combination of HLA-transgenic mice, recombinant adenovirus and antigen peptide libraries. [PDF]

PLoS ONE, 2010
BACKGROUND: As tumor antigen-specific CD4+ T cells can mediate strong therapeutic anti-tumor responses in melanoma patients we set out to establish a comprehensive screening strategy for the identification of tumor-specific CD4+ T cell epitopes suitable ...
Wolfram Osen, Sabine Soltek, Mingxia Song, Barbara Leuchs, Julia Steitz, Thomas Tüting, Stefan B Eichmüller, Xuan-Duc Nguyen, Dirk Schadendorf, Annette Paschen   +9 more
doaj   +1 more source

Antigens for CD4 and CD8 T Cells in Tuberculosis [PDF]

Cold Spring Harbor Perspectives in Medicine, 2014
Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (MTB), represents an important cause of morbidity and mortality worldwide for which an improved vaccine and immunodiagnostics are urgently needed. CD4(+) and CD8(+) T cells play an important role in host defense to TB.
Cecilia S, Lindestam Arlehamn, David, Lewinsohn, Alessandro, Sette, Deborah, Lewinsohn   +3 more
openaire   +2 more sources

How Thymocyte Deletion in the Cortex May Curtail Antigen-Specific T-Regulatory Cell Development in the Medulla

Frontiers in Immunology, 2022
CD4+ T cell responses to self-antigens are pivotal for immunological self-tolerance. Activation of Foxp3– T-conventional (T-conv) cells can precipitate autoimmune disease, whereas activation of Foxp3+ T-regulatory (T-reg) cells is essential to prevent ...
Chenglong Wang, Stephen R. Daley
doaj   +1 more source

Blastic plasmacytoid dendritic cell neoplasm [PDF]

Anais Brasileiros de Dermatologia, 2013
Blastic plasmacytoid dendritic cell neoplasm is a rare and aggressive hematodermic neoplasia with frequent cutaneous involvement and leukemic dissemination.
André Lencastre, Joana Cabete, Alexandre João, Pedro Farinha, Gilda Ferreira, Sara Lestre   +5 more
doaj   +1 more source