Results 21 to 30 of about 665,801 (300)

Epitopes of the CD4 Antigen and HIV Infection

Science, 1986
The CD4 (or T4) surface antigen of human T lymphocytes is an important part of the receptor for the human immunodeficiency virus (HIV). After binding to the receptor, the HIV may enter the T cell and induce the formation of syncytia. In an attempt to identify the receptor site more closely, monoclonal antibodies (Mab's) to CD4 were tested ...
Sattentau, Q, Dalgleish, A, Weiss, R, Beverley, P   +3 more
openaire   +3 more sources

Dynamic Adoption of Anergy by Antigen-Exhausted CD4+ T Cells [PDF]

The Journal of Immunology, 2021
Abstract Exhausted immune responses to chronic diseases represent a major challenge to global health. To explore their cell fate and plasticity in exhaustion, we analyzed CD4+T cells in a mouse model with regulatable antigen presentation.
Trefzer, A., Kadam, P., Wang, S.H., Pennavaria, S., Lober, B., Akçabozan, B., Kranich, J., Brocker, T., Nakano, N., Irmler, M., Beckers, J., Straub, T., Obst, R.   +12 more
openaire   +4 more sources

Correlation of memory T cell responses against TRAP with protection from clinical malaria, and CD4+ CD25high T cells with susceptibility in Kenyans [PDF]

, 2008
Background - Immunity to malaria develops naturally in endemic regions, but the protective immune mechanisms are poorly understood. Many vaccination strategies aim to induce T cells against diverse pre-erythrocytic antigens, but correlates of protection ...
Magdalena Plebanski, Stephen M. Todryk, Plebanski Magdalena, Hill, Adrian, Tabitha Mwangi, Kevin Marsh, Urban Britta, Flanagan Katie L., Mwangi Tabitha, Plebanski, Magdalena, Britta Urban, Todryk, Stephen, Hill Adrian V. S., Urban, Britta, Katie L Flanagan, Philip Bejon, Bejon, Philip, Marsh Kevin, Mwangi, Tabitha, Flanagan, Katie, Bejon Philip, Katie L. Flanagan, Adrian V S Hill, Todryk Stephen M., Adrian V. S. Hill, Stephen M Todryk, Marsh, Kevin   +26 more
core   +1 more source

Expansion of T regulatory lymphocytes by murine bone marrow dendritic cells previously stimulated with Anisakis simplex larval antigens [PDF]

Memorias do Instituto Oswaldo Cruz, 2021
BACKGROUND Anisakis simplex antigens present immunomodulatory properties by the induction of tolerogenic dendritic cells (DCs) in mice. OBJECTIVES To study the capacity of DCs stimulated with A. simplex excretory-secretory (ES) or crude extract (CE) to
Vega Zamora, Marta Rodero, Alexandra Ibáñez-Escribano, Juan C Andreu-Ballester, Susana Mendez, Carmen Cuéllar   +5 more
doaj   +1 more source

CD4 T cells and their antigens in the pathogenesis of autoimmune diabetes [PDF]

Current Opinion in Immunology, 2011
Pathogenesis of type 1 diabetes (T1D) is mediated by effector T cells and CD4 Th1 and Th17T cells have important roles in this process. While effector function of Th1 cells is well established, because of their inherent plasticity Th17 cells have been more controversial.
Kathryn, Haskins, Anne, Cooke
openaire   +2 more sources

The Effect of a Linear Tuning between the Antigenic Stimulations of CD4+ T Cells and CD4+ Tregs [PDF]

Mathematics, 2020
We study the equilibria of an Ordinary Differencial Equation (ODE) system where CD4 + effector or helper T cells and Regulatory T cells (Tregs) are present. T cells trigger an immune response in the presence of their specific antigen. Regulatory T cells (Tregs) play a role in limiting auto-immune diseases due to their immune-suppressive ability.
Aliyu Yusuf, Isabel Figueiredo, Atefeh Afsar, Nigel Burroughs, Alberto Pinto, Bruno Oliveira   +5 more
openaire   +4 more sources

CD4 expression decrease by antisense oligonucleotides. Inhibition of rat T CD4+ cell reactivity [PDF]

, 2012
In previous studies, we have demonstrated the inhibition of CD4 expression in rat lymphocytes treated with phorbol myristate acetate (PMA) by antisense oligonucleotides (AS-ODNs) directed against the AUG start region of the cd4 gene.
Ciudad i Gómez, Carlos Julián, Castellote i Bargalló, M. Cristina, Castell, Margarida, Noé Mata, Verónica, Rabanal i Tornero, Manel, Pelegrí, Carme, Franch, Àngels   +6 more
core   +1 more source

Mycobacterial antigens in pleural fluid mononuclear cells to diagnose pleural tuberculosis in HIV co-infected patients

BMC Infectious Diseases, 2020
Background Extra pulmonary manifestation of tuberculosis (TB) accounts for approximately one-half of TB cases in HIV-infected individuals with pleural TB as the second most common location. Even though mycobacteria are cleared, mycobacterial antigens may
Tehmina Mustafa, Ida Wergeland, Kamaldeen Baba, Sharad Pathak, Anwar A. Hoosen, Anne Margarita Dyrhol-Riise   +5 more
doaj   +1 more source

How Thymocyte Deletion in the Cortex May Curtail Antigen-Specific T-Regulatory Cell Development in the Medulla

Frontiers in Immunology, 2022
CD4+ T cell responses to self-antigens are pivotal for immunological self-tolerance. Activation of Foxp3– T-conventional (T-conv) cells can precipitate autoimmune disease, whereas activation of Foxp3+ T-regulatory (T-reg) cells is essential to prevent ...
Chenglong Wang, Stephen R. Daley
doaj   +1 more source

Simultaneous expression of CD4 and CD8 antigens by a substantial proportion of resting porcine T lymphocytes [PDF]

, 1987
The existence of four subpopulations in resting porcine T lymphocytes is documented. In addition to the two known subpopulations which are typified by a mutually exclusive expression of either the CD8 or the CD4 differentiation antigen, CD4-CD8+ and CD4 ...
Saalmüller, Armin, Reddehase, Matthias J., Koszinowski, Ulrich H., Hans‐Jörg Bühring, Bühring, Hans‐Jörg, Koszinowski, Ulrich, Stipan Jonjić, Armin Saalmüller, Bühring, Hans-Jörg, Jonjic, Stipan, Matthias J. Reddehase, Ulrich H. Koszinowski   +11 more
core   +3 more sources