Immunity to intracellular Salmonella depends on surface-associated antigens. [PDF]
PLoS Pathogens, 2012 Invasive Salmonella infection is an important health problem that is worsening because of rising antimicrobial resistance and changing Salmonella serovar spectrum.
Somedutta Barat +9 more
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Antigens for CD4 and CD8 T Cells in Tuberculosis [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (MTB), represents an important cause of morbidity and mortality worldwide for which an improved vaccine and immunodiagnostics are urgently needed. CD4(+) and CD8(+) T cells play an important role in host defense to TB.
Cecilia S, Lindestam Arlehamn +3 more
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Synergy between CD8 T cells and Th1 or Th2 polarised CD4 T cells for adoptive immunotherapy of brain tumours. [PDF]
PLoS ONE, 2013 The feasibility of cancer immunotherapy mediated by T lymphocytes is now a clinical reality. Indeed, many tumour associated antigens have been identified for cytotoxic CD8 T cells, which are believed to be key mediators of tumour rejection.
Sabine Hoepner +6 more
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Epitopes of the CD4 Antigen and HIV Infection
Science, 1986 The CD4 (or T4) surface antigen of human T lymphocytes is an important part of the receptor for the human immunodeficiency virus (HIV). After binding to the receptor, the HIV may enter the T cell and induce the formation of syncytia. In an attempt to identify the receptor site more closely, monoclonal antibodies (Mab's) to CD4 were tested ...
Sattentau, Q +3 more
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CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells
Nature Communications, 2022 CD4 and CD8 co-receptors are routinely used to define distinct functional and phenotypic lineages of T cells. Here the authors show CD4 and CD8 also modulate the functional avidity of the CD1b-restricted response to mycobacterial lipid ...
Charlotte A. James +11 more
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QuilA-adjuvanted T. gondii lysate antigens trigger robust antibody and IFNγ+ T cell responses in pigs leading to reduction in parasite DNA in tissues upon challenge infection [PDF]
, 2019 Toxoplasma gondii is an intracellular parasite of all mammals and birds, responsible for toxoplasmosis. In healthy individuals T. gondii infections mostly remain asymptomatic, however this parasite causes severe morbidity and mortality in ...
Cox, Eric +6 more
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NK Cells Regulate CD4 Responses Prior to Antigen Encounter [PDF]
The Journal of Immunology, 2003 Abstract NK cells not only respond rapidly to infection, shaping subsequent adaptive immunity, but also play a role in regulating autoimmune disease. The ability of NK cells to influence adaptive immunity before Ag exposure was examined in a gender-dependent model of preferential Th1 and Th2 activation.
Kennichi C, Dowdell +3 more
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Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance T-cell receptor recognition of antigen is an essential first step in the initiation of a T-cell response. This report demonstrates that CD4 T cells responding during an infection can discriminate between antigen affinity and antigen dose, resulting in distinct types of effector and memory cell generation. Moreover, memory
Keck, Simone +7 more
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CD4+CD25hiFOXP3+ cells in cord blood of neonates born from filaria infected mother are negatively associated with CD4+Tbet+ and CD4+RORγt+ T cells. [PDF]
PLoS ONE, 2014 BACKGROUND:Children who have been exposed in utero to maternal filarial infection are immunologically less responsive to filarial antigens, have less pathology, and are more susceptible to acquire infection than offspring of uninfected mothers.
Ulysse Ateba-Ngoa +9 more
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Memorias do Instituto Oswaldo Cruz, 2014 The effects of human immunodeficiency virus (HIV) on the immune response in patients with cutaneous leishmaniasis have not yet been fully delineated.
Luana Leandro Gois +5 more
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