Results 21 to 30 of about 221,142 (316)

CD4 T cells and their antigens in the pathogenesis of autoimmune diabetes [PDF]

Current Opinion in Immunology, 2011
Pathogenesis of type 1 diabetes (T1D) is mediated by effector T cells and CD4 Th1 and Th17T cells have important roles in this process. While effector function of Th1 cells is well established, because of their inherent plasticity Th17 cells have been more controversial.
Kathryn, Haskins, Anne, Cooke
openaire   +2 more sources

Virus and autoantigen-specific CD4+ T cells are key effectors in a SCID mouse model of EBV-associated post-transplant lymphoproliferative disorders. [PDF]

PLoS Pathogens, 2014
Polyclonal Epstein-Barr virus (EBV)-infected B cell line (lymphoblastoid cell lines; LCL)-stimulated T-cell preparations have been successfully used to treat EBV-positive post-transplant lymphoproliferative disorders (PTLD) in transplant recipients, but ...
Stefanie Linnerbauer, Uta Behrends, Dinesh Adhikary, Klaus Witter, Georg W Bornkamm, Josef Mautner   +5 more
doaj   +1 more source

New perspective on dextran sodium sulfate colitis: antigen-specific T cell development during intestinal inflammation. [PDF]

PLoS ONE, 2013
CD4+ T cell responses against oral antigens can develop in inflammatory bowel disease (IBD) patients, which may modulate disease. Dextran sodium sulfate (DSS) colitis is commonly used to study IBD, however, it is not considered the best model in which to
Mary E Morgan, Bin Zheng, Pim J Koelink, Hendrick J G van de Kant, Lizette C J M Haazen, Manon van Roest, Johan Garssen, Gert Folkerts, Aletta D Kraneveld   +8 more
doaj   +1 more source

Epitopes of the CD4 Antigen and HIV Infection

Science, 1986
The CD4 (or T4) surface antigen of human T lymphocytes is an important part of the receptor for the human immunodeficiency virus (HIV). After binding to the receptor, the HIV may enter the T cell and induce the formation of syncytia. In an attempt to identify the receptor site more closely, monoclonal antibodies (Mab's) to CD4 were tested ...
Sattentau, Q, Dalgleish, A, Weiss, R, Beverley, P   +3 more
openaire   +3 more sources

The dysfunction of CD4(+)CD25(+) regulatory T cells contributes to the abortion of mice caused by Toxoplasma gondii excreted-secreted antigens in early pregnancy.

PLoS ONE, 2013
Toxoplasma gondii is an opportunistic intracellular parasite that is highly prevalent in human and warm-blooded animals throughout the world, leading to potentially severe congenital infections. Although the abortion caused by T. gondii is believed to be
Jin-ling Chen, Yi-yue Ge, Jie Zhang, Xiao-yan Qiu, Jing-fan Qiu, Jiang-ping Wu, Yong Wang   +6 more
doaj   +1 more source

Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue [PDF]

, 2011
The upper respiratory tract mucosa is the location for commensal Streptococcus (S.) pneumoniae colonization and therefore represents a major site of contact between host and bacteria.
Mitchell, T.J., Pido-Lopez Jeffrey, Pido-Lopez, J., Mitchell, TJ, Williams Neil A., Kwok, William W, Robert S. Heyderman, Neil A. Williams, Mitchell, Timothy J, Heyderman Robert S., Robert S Heyderman, Williams, NA, Pido, J, Neil A Williams, Mitchell Timothy J., Timothy J. Mitchell, Timothy J Mitchell, Heyderman, R.S., Pido-Lopez, Jeffrey, Kwok, W, Kwok William W., Williams, N.A., Heyderman, RS, William W Kwok, Jeffrey Pido-Lopez, Williams, Neil A, Kwok, W.W., William W. Kwok, Heyderman, Robert S   +28 more
core   +1 more source

Mycobacterial antigens in pleural fluid mononuclear cells to diagnose pleural tuberculosis in HIV co-infected patients

BMC Infectious Diseases, 2020
Background Extra pulmonary manifestation of tuberculosis (TB) accounts for approximately one-half of TB cases in HIV-infected individuals with pleural TB as the second most common location. Even though mycobacteria are cleared, mycobacterial antigens may
Tehmina Mustafa, Ida Wergeland, Kamaldeen Baba, Sharad Pathak, Anwar A. Hoosen, Anne Margarita Dyrhol-Riise   +5 more
doaj   +1 more source

Synergy between CD8 T cells and Th1 or Th2 polarised CD4 T cells for adoptive immunotherapy of brain tumours. [PDF]

PLoS ONE, 2013
The feasibility of cancer immunotherapy mediated by T lymphocytes is now a clinical reality. Indeed, many tumour associated antigens have been identified for cytotoxic CD8 T cells, which are believed to be key mediators of tumour rejection.
Sabine Hoepner, Jacelyn M S Loh, Cristina Riccadonna, Madiha Derouazi, Céline Yacoub Maroun, Pierre-Yves Dietrich, Paul R Walker   +6 more
doaj   +1 more source

Analysis of host responses to Mycobacterium tuberculosis antigens in a multi-site study of subjects with different TB and HIV infection states in sub-Saharan Africa. [PDF]

, 2013
BACKGROUND: Tuberculosis (TB) remains a global health threat with 9 million new cases and 1.4 million deaths per year. In order to develop a protective vaccine, we need to define the antigens expressed by Mycobacterium tuberculosis (Mtb), which are ...
Kaufmann, S.H.E., Ambrose, Lyn R., Gomez, M., Martin Ota (198869), Lalor, M., Donkor Simon, Novel N Chegou, Kees Franken, Willem Hanekom (23103), Gerhard Walzl (149313), Mihret, A., Crampin, Amelia C, Simon Donkor (343534), Parida, S., Thiel Bonnie A., Hazel M Dockrell, Hanekom, Willem, GCGH Biomarkers for TB consortium, Amelia C Crampin, Parida, Shreemanta K., Kassa, Desta, Loxton, Andre G., Gomez, M.P., Martin Ota, Crampin, Amelia C., Loxton, Andre G, Rawleigh Howe (456745), Hanekom Willem, Parida Shreemanta K., W. Henry Boom (125099), Simon Donkor, Lalor, Maeve K., Ambrose, Lyn R, Andre G. Loxton (160294), Howe Rawleigh, Dockrell Hazel M., Kassa Desta, Gomez, Marie P., Boom, W. Henry, Sutherland, Jayne S, Franken Kees, Ota, Martin, Stefan H E Kaufmann, GCGH Biomarkers TB Consortium, Stefan H. E. Kaufmann (149315), Walzl, G., Crampin, A.C., Mayanja-Kizza Harriet, Sutherland, Jayne S., Michel R. Klein (160302), Lalor Maeve K., Black, Gillian F, Chegou Novel N., Black, G., Harriet Mayanja-Kizza (78637), Donkor, S., Maeve K Lalor, Gomez Marie P., Boom, W.H., Donkor, Simon, Kassa, D., Loxton, A.G., Kees Franken (456747), Amelia C. Crampin (239427), Ambrose, L.R., Desta Kassa (456743), Crampin, A., Black, Gillian F., Thiel, Bonnie A., Ambrose Lyn R., Dockrell, Hazel M., Lyn R Ambrose, Adane Mihret, Hazel M. Dockrell (255469), Klein Michel R., Parida, Shreemanta K, Franken, K., Dockrell, H.M., Walzl Gerhard, Kaufmann, Stefan H.E., Boom, W Henry, Shreemanta K. Parida (149299), Klein, Michel R., Chegou, Novel N, Klein, M.R., Bonnie A Thiel, Lyn R. Ambrose (456742), Ota Martin, Thiel, B.A., Andre G Loxton, Sutherland, J., Shreemanta K Parida, Harriet Mayanja-Kizza, Ottenhoff Tom H. M., Ota, M., Loxton, A., Howe, R., Mayanja-Kizza, H., Ottenhoff, Tom HM, Tom H M Ottenhoff, Cardona, Pere-Joan, Ottenhoff, T.H.M., Willem Hanekom, Crampin Amelia C., Gomez, Marie P, Novel N. Chegou (160288), Chegou, Novel N., Klein, M., Sutherland, J.S., Lalor, M.K., Thiel, Bonnie A, Bonnie A. Thiel (456748), Maeve K. Lalor (356874), Ottenhoff, T., Walzl, Gerhard, Gillian F. Black (149301), Boom W. Henry, Ambrose, L., Hanekom, W., Marie P Gomez, Lalor, Maeve K, Adane Mihret (456744), Chegou, N.N., Marie P. Gomez (456746), Jayne S Sutherland, Sutherland Jayne S., Klein, Michel R, Chegou, N., Jayne S. Sutherland (334202), Kaufmann, Stefan HE, Parida, S.K., Mihret Adane, Kaufmann Stefan H. E., Ottenhoff, Tom H.M., W Henry Boom, Rawleigh Howe, Thiel, B., Gerhard Walzl, Tom H. M. Ottenhoff (160303), Gillian F Black, Dockrell, H., Black Gillian F., Howe, Rawleigh, Boom, W., Black, G.F., Loxton Andre G., Desta Kassa, Ottenhoff, Tom H M, Kaufmann, S., Mihret, Adane, Franken, Kees, Mayanja-Kizza, Harriet, Michel R Klein, Kaufmann, Stefan H E, Dockrell, Hazel M   +154 more
core   +1 more source

CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells

Nature Communications, 2022
CD4 and CD8 co-receptors are routinely used to define distinct functional and phenotypic lineages of T cells. Here the authors show CD4 and CD8 also modulate the functional avidity of the CD1b-restricted response to mycobacterial lipid ...
Charlotte A. James, Yuexin Xu, Melissa S. Aguilar, Lichen Jing, Erik D. Layton, Martine Gilleron, Adriaan J. Minnaard, Thomas J. Scriba, Cheryl L. Day, Edus H. Warren, David M. Koelle, Chetan Seshadri   +11 more
doaj   +1 more source