Results 21 to 30 of about 211,397 (266)

CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells

Nature Communications, 2022
CD4 and CD8 co-receptors are routinely used to define distinct functional and phenotypic lineages of T cells. Here the authors show CD4 and CD8 also modulate the functional avidity of the CD1b-restricted response to mycobacterial lipid ...
Charlotte A. James, Yuexin Xu, Melissa S. Aguilar, Lichen Jing, Erik D. Layton, Martine Gilleron, Adriaan J. Minnaard, Thomas J. Scriba, Cheryl L. Day, Edus H. Warren, David M. Koelle, Chetan Seshadri   +11 more
doaj   +1 more source

Decreased memory T-cell response and function in human immunodeficiency virus-infected patients with tegumentary leishmaniasis

Memorias do Instituto Oswaldo Cruz, 2014
The effects of human immunodeficiency virus (HIV) on the immune response in patients with cutaneous leishmaniasis have not yet been fully delineated.
Luana Leandro Gois, Sanjay Mehta, Maria Zilma Andrade Rodrigues, Robert T Schooley, Roberto Badaro, Maria Fernanda Rios Grassi   +5 more
doaj   +1 more source

Secretory Microneme Proteins Induce T-Cell Recall Responses in Mice Chronically Infected with Toxoplasma gondii

mSphere, 2019
Microneme (MIC) proteins play important roles in the recognition, adhesion, and invasion of host cells by Toxoplasma gondii. Previous studies have shown that MIC proteins are highly immunogenic in the mouse and recognized by human serum antibodies.
Iti Saraav, Qiuling Wang, Kevin M. Brown, L. David Sibley   +3 more
doaj   +1 more source

CD4+CD25hiFOXP3+ cells in cord blood of neonates born from filaria infected mother are negatively associated with CD4+Tbet+ and CD4+RORγt+ T cells. [PDF]

PLoS ONE, 2014
BACKGROUND:Children who have been exposed in utero to maternal filarial infection are immunologically less responsive to filarial antigens, have less pathology, and are more susceptible to acquire infection than offspring of uninfected mothers.
Ulysse Ateba-Ngoa, Ghyslain Mombo-Ngoma, Eva Zettlmeissl, Luciën E P M van der Vlugt, Sanne E de Jong, Pierre-Blaise Matsiegui, Michael Ramharter, Peter G Kremsner, Maria Yazdanbakhsh, Ayola Akim Adegnika   +9 more
doaj   +1 more source

Immunodominance of lytic cycle antigens in Epstein-Barr virus-specific CD4+ T cell preparations for therapy.

PLoS ONE, 2007
BackgroundEpstein-Barr virus (EBV) is associated with a number of human malignancies. EBV-positive post-transplant lymphoproliferative disease in solid organ and hematopoietic stem cell transplant recipients has been successfully treated by the adoptive ...
Dinesh Adhikary, Uta Behrends, Heike Boerschmann, Andrea Pfünder, Stefan Burdach, Andreas Moosmann, Klaus Witter, Georg W Bornkamm, Josef Mautner   +8 more
doaj   +1 more source

Sézary Syndrome with CD4/CD8 Double-Negative Neoplastic T Cells in Peripheral Blood

Case Reports in Hematology, 2021
Sézary syndrome is a rare leukemic type of cutaneous T-cell lymphoma characterized by the presence of neoplastic T cells with cerebriform nuclei (Sézary cells) in the skin, lymph nodes, and peripheral blood.
Yuki Kageyama, Kenshiro Tsuda, Yuma Nato, Keiki Nagaharu, Kazutaka Suzuki, Akihiko Sawaki, Hiroyuki Miyashita   +6 more
doaj   +1 more source

Involvement of Different CD4+ T Cell Subsets Producing Granzyme B in the Immune Response to Leishmania major Antigens

Mediators of Inflammation, 2014
The nature of effector cells and the potential immunogenicity of Leishmania major excreted/secreted proteins (LmES) were evaluated using peripheral blood mononuclear cells (PBMCs) from healed zoonotic cutaneous leishmaniasis individuals (HZCL) and ...
Ikbel Naouar, Thouraya Boussoffara, Melika Ben Ahmed, Nabil Belhaj Hmida, Adel Gharbi, Sami Gritli, Afif Ben Salah, Hechmi Louzir   +7 more
doaj   +1 more source

Intratumor childhood vaccine-specific CD4+ T-cell recall coordinates antitumor CD8+ T cells and eosinophils

Journal for ImmunoTherapy of Cancer, 2023
Background Antitumor mechanisms of CD4+ T cells remain crudely defined, and means to effectively harness CD4+ T-cell help for cancer immunotherapy are lacking. Pre-existing memory CD4+ T cells hold potential to be leveraged for this purpose.
Daniel Landi, Annick Desjardins, Matthias Gromeier, Darell D Bigner, Smita K Nair, Michael C Brown, Georgia M Beasley, David M Ashley, Yuanfan Yang, Zachary P McKay, Dina M Randazzo   +10 more
doaj   +1 more source

Flow Cytometric Analysis of T, B, and NK Cells Antigens in Patients with Mycosis Fungoides

Journal of Immunology Research, 2015
We retrospectively analyzed the clinicopathological correlation and prognostic value of cell surface antigens expressed by peripheral blood mononuclear cells in patients with mycosis fungoides (MF). 121 consecutive MF patients were included in this study.
Serkan Yazıcı, Emel Bülbül Başkan, Ferah Budak, Barbaros Oral, Şaduman Balaban Adim, Zübeyde Ceylan Kalin, Güven Özkaya, Kenan Aydoğan, Hayriye Saricaoğlu, Şükran Tunali   +9 more
doaj   +1 more source

EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture

eLife, 2013
Splenic dendritic cells (DCs) present blood-borne antigens to lymphocytes to promote T cell and antibody responses. The cues involved in positioning DCs in areas of antigen exposure in the spleen are undefined.
Tangsheng Yi, Jason G Cyster
doaj   +1 more source