Results 41 to 50 of about 665,801 (300)

Secretory Microneme Proteins Induce T-Cell Recall Responses in Mice Chronically Infected with Toxoplasma gondii

mSphere, 2019
Microneme (MIC) proteins play important roles in the recognition, adhesion, and invasion of host cells by Toxoplasma gondii. Previous studies have shown that MIC proteins are highly immunogenic in the mouse and recognized by human serum antibodies.
Iti Saraav, Qiuling Wang, Kevin M. Brown, L. David Sibley   +3 more
doaj   +1 more source

Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses

Nature Communications, 2017
Antigen presentation is generally considered the domain of innate immune cells, but CD4+ T cells can transphagocytose bacteria from infected dendritic cells.
Aránzazu Cruz-Adalia, Guillermo Ramirez-Santiago, Jesús Osuna-Pérez, Mónica Torres-Torresano, Virgina Zorita, Ana Martínez-Riaño, Viola Boccasavia, Aldo Borroto, Gloria Martínez del Hoyo, José María González-Granado, Balbino Alarcón, Francisco Sánchez-Madrid, Esteban Veiga   +12 more
doaj   +1 more source

CD4+ T Responses Other Than Th1 Type Are Preferentially Induced by Latency-Associated Antigens in the State of Latent Mycobacterium tuberculosis Infection

Frontiers in Immunology, 2019
Mycobacterium tuberculosis (M. tuberculosis) produces a diverse range of antigenic proteins in its dormant phase. The cytokine profiles of CD4+ T cell responses, especially subsets other than Th1 type (non-Th1 type), against these latency-associated M ...
Yoshiro Yamashita, Toshiyuki Oe, Kenji Kawakami, Mayuko Osada-Oka, Yuriko Ozeki, Kazutaka Terahara, Ikkoh Yasuda, Tansy Edwards, Takeshi Tanaka, Takeshi Tanaka, Yasuko Tsunetsugu-Yokota, Yasuko Tsunetsugu-Yokota, Sohkichi Matsumoto, Sohkichi Matsumoto, Koya Ariyoshi, Koya Ariyoshi   +15 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Expression of CCR6 on Helicobacter pylori-specific circulating CD4+ T cells

Инфекция и иммунитет
Introduction. Helicobacter pylori can infect human gastric mucosa and cause various pathological conditions. In the blood of H. pylori-infected patients, the level of mature CD4+CCR6+ T-lymphocytes, especially pro-inflammatory CCR6+ T-helper types 1 and ...
Vladimir Yu. Talayev, I. Ye. Zaichenko, M. V. Svetlova, E. V. Voronina, O. N. Babaykina, N. V. Neumoina, K. M. Perfilova   +6 more
doaj   +1 more source

Synergy between CD8 T cells and Th1 or Th2 polarised CD4 T cells for adoptive immunotherapy of brain tumours. [PDF]

PLoS ONE, 2013
The feasibility of cancer immunotherapy mediated by T lymphocytes is now a clinical reality. Indeed, many tumour associated antigens have been identified for cytotoxic CD8 T cells, which are believed to be key mediators of tumour rejection.
Sabine Hoepner, Jacelyn M S Loh, Cristina Riccadonna, Madiha Derouazi, Céline Yacoub Maroun, Pierre-Yves Dietrich, Paul R Walker   +6 more
doaj   +1 more source

CD4⁺ T cells reactive to Epstein-Barr virus late lytic antigens are enriched in individuals with multiple sclerosis. [PDF]

Sci Transl Med
Multiple sclerosis (MS) pathogenesis is linked to Epstein-Barr virus (EBV), but the underlying immune mechanisms remain unclear. Using an optimized T cell assay, we demonstrate that CD4 + T ...
Bjornevik K, Mahler JV, Bilodeau PA, Rød BE, Romanow G, Mikami T, Anderson M, Bobrowski-Khoury N, Zhu H, Nguyen J, Sun Y, Matiello M, Housman D, Nourbakhsh B, Myhr KM, Torkildsen Ø, Sollid LM, Levy M, Drosu N.   +18 more
europepmc   +2 more sources

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Identification of DRG-1 As a Melanoma-Associated Antigen Recognized by CD4+ Th1 Cells. [PDF]

PLoS ONE, 2015
Immunotherapy has emerged as a promising strategy for the treatment of metastatic melanoma. Clinical studies have demonstrated the feasibility of cancer immunotherapy using tumor antigens recognized by CD8(+) T cells.
Yukiko Kiniwa, Jiang Li, Mingjun Wang, Chuang Sun, Jeffrey E Lee, Rong-Fu Wang, Helen Y Wang   +6 more
doaj   +1 more source