Results 121 to 130 of about 98,906 (300)

Age-related impairment of human T lymphocytes' activation: specific differences between CD4+ and CD8+ subsets

, 2006
The relevance of physiological immune aging is of great interest with respect to determining disorders with pathologic immune function in aging individuals.
Maurer, Konrad, Schindowski, Katharina, Frölich, Lutz, Eckert, Anne, Müller, Walter E.   +4 more
core  

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

TOTAL LYMPHOCYTE COUNT AS A PROGNOSTIC MARKER FOR CD4 COUNT IN RESOURCE LIMITED SETTINGS

, 2013
Understanding the Total lymphocyte count (TLC) and CD4 relationship could aid design predictive instruments for making clinical decisions during antiretroviral therapy.
G.I., Ahaneku, P.O, Manafa, G.O., Chukwuma, O.M., Chukwuma, N., Ndembi, F.O., Nwaokorie, G. O., Ezeifeka, S.O., Kalu   +7 more
core   +2 more sources

Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction

Advanced Science, EarlyView.
This study presents the Tech‐tetrahedron, a designer dynamic DNA nanoaggregate engineered for precise mitochondrial energy restriction. Its trinity‐functionalized design integrates navigable unit, telomerase‐activated latch, and self‐assembly module.
Ruijia Deng, Jing Sheng, Ben Niu, Wenjuan Fu, Yingjie Yang, Zuowei Xie, Shuang Xie, Yunxuan He, Meilin Gong, Jue Wang, Yan Pi, Ming Chen, Kai Chang   +12 more
wiley   +1 more source

The Predictive Value of Absolute Lymphocyte Count and T Cell Subpopulations for Sepsis Prognosis

Infection and Drug Resistance
Xi Jia,1,2,* Xiaojing Li,3,* Linzi Miao,1 Rong Bao,4 Hui Xiong,3 Ran You,1 Yao Lu,1 Xiaoning Gui,1 Chenxue Qu1 1Department of Clinical Laboratory, Peking University First Hospital, Beijing, People’s Republic of China; 2Department of Clinical ...
Jia X, Li X, Miao L, Bao R, Xiong H, You R, Lu Y, Gui X, Qu C   +8 more
doaj  

Predictors of CD4+ lymphocyte count among HIV-Seropositive and HIV-Seronegative pregnant women in Dar Es Salaam, Tanzania

, 2009
Objective: To determine the predictors of CD4+ lymphocyte count among pregnant women in Dar es Salaam, Tanzania.Methods: Between 04/1995 and 03/1997, HIV-seropositive (n=1,027) and HIV- seronegative (n=280) pregnant women were interviewed to obtain socio-
GI Msamanga, Kapiga, SH, D Hunter, D Mwakagile, Mwakagile, D, SH Kapiga, Fawzi, WW, WW Fawzi, Hunter, D, D Spiegelman, Spiegelman, D, Msamanga, GI   +11 more
core   +2 more sources

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, EarlyView.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source

CD4 and total lymphocyte count [PDF]

QJM, 1997
openaire   +2 more sources

Distribution of QuantiFERON-TB® Gold In-Tube results by CD4⁺ lymphocyte count.

, 2013
Proportion of both negative and indeterminate results increased with falling CD4+ lymphocyte count. QGIT, QuantiFERON-TB® Gold In-Tube.
Petra De Haas (59112), Joseph Banda (59111), Maureen Moyo (59109), Edward Raby (59108), Akash Devendra (59110), Helen Ayles (42807), Peter Godfrey-Faussett (17915)   +6 more
core   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source