Results 101 to 110 of about 98,906 (300)

HIV and decreased risk of multiple sclerosis: role of low CD4+ lymphocyte count and male prevalence [PDF]

, 2017
In this retrospective case-control study, we compared the number of circulating lymphocyte subsets among 31 healthy controls, 18 naïve and 40 antiretroviral-treated HIV patients, 28 untreated and 18 treated relapsing-remitting multiple sclerosis (MS ...
Mandoj C., Plantone D., Koudriavtseva T., Cordiali-Fei P., Pimpinelli F., Latini A., Giannarelli D., Colafigli M., Trento E.   +8 more
core   +1 more source

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

Advanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng, Chao He, Zhibin He, Hongbo Chen, Fang Cheng, Yongjiang Zheng   +5 more
wiley   +1 more source

Cox proportional-hazards regression analysis for independent associations between the survival time and the IPI, CD4 count and a lymphocyte count <1.3 x 10⁹/L.

, 2023
Cox proportional-hazards regression analysis for independent associations between the survival time and the IPI, CD4 count and a lymphocyte count 9/L.
Jenifer Vaughan (12102112), Tracey Wiggill (14380907), Denise Lawrie (9156791), Merriam Machaba (14380910), Moosa Patel (14380913)   +4 more
core   +1 more source

Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC

Advanced Science, EarlyView.
Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang, Lin Ding, Yu Zhong, Haokang Feng, Linglong Huang, Waidong Huang, Chunqing Wang, Arne Östman, Beili Wang, Jian Zhou, Jia Fan, Wei Guo, Liang Wu, Yunfan Sun   +13 more
wiley   +1 more source

Mathematical predictive relationship of CD4+ lymphocytes and total leukocytes in HIV-infected patients

HIV & AIDS Review. International Journal of HIV-Related Problems
Introduction Different parameters have been established to direct the treatment of patients with human immunodeficiency virus (HIV) infection, such as CD4+ lymphocyte values, and it is of clinical interest to have methodologies that accurately predict ...
Signed Esperanza Prieto Bohorquez, Joao Cuesta, César Alejandro Valdés Cadena, Carlos Eduardo Pérez Díaz, Sandra Medina Araujo, Ribká Soracipa Muñoz, Andrés David Ibarra, Eduardo Méndez Pino, Sandra Catalina Correa Herrera, Javier Oswaldo Rodríguez Velasquez   +9 more
doaj   +1 more source

Real World Lab Data: Patterns of Lymphocyte Counts in Fingolimod Treated Patients

Frontiers in Immunology, 2018
Objective:Fingolimod is approved for the treatment of highly active relapsing remitting multiple sclerosis (MS) patients and acts by its unique mechanism of action via sphingosine-1-phosphate receptor-modulation.
Maxi Kaufmann, Rocco Haase, Undine Proschmann, Tjalf Ziemssen, Katja Akgün   +4 more
doaj   +1 more source

Association of KIR/HLA alleles with baseline CD4⁺ lymphocyte count.

, 2016
Association of KIR/HLA alleles with baseline CD4+ lymphocyte count.
Stephen A. Spector (298587), Min Qin (123347), Sean S. Brummel (753221), Rodney N. Trout (3178479), Kumud K. Singh (320595), Konstantia Angelidou (3178476), Terence Fenton (705082)   +6 more
core   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Thymic function and T cell parameters in a natural human experimental model of seasonal infectious diseases and nutritional burden [PDF]

, 2011
BACKGROUND:The study exploits a natural human experimental model of subsistence farmers experiencing chronic and seasonally modified food shortages and infectious burden.
Ngom, Pa T, Solon Juan, Ngom Pa T, Andrew M Prentice, Morgan Gareth, Juan Solon, Prentice Andrew M, Richard Aspinall, Morgan, Gareth, Pa T Ngom, Prentice, Andrew M, Sophie E Moore, Aspinall, Richard, Gareth Morgan, Moore, Sophie E, Solon, Juan, Ngom, Pa T., Moore, Sophie E., Prentice, Andrew M., Aspinall Richard, Moore Sophie E   +20 more
core   +1 more source

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source