Results 31 to 40 of about 96,682 (259)

Baseline CD4 count and the time interval between the initial HIV infection and diagnosis among PLHIV in Bhutan

Immunity, Inflammation and Disease, 2021
Introduction CD4 count is an important predictor of disease progression, opportunities infection, deaths, and to understand the time interval between initial HIV infection to the first diagnosis.
Lekey khandu, Guru P. Dhakal, Karma Lhazeen   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Pneumocystis jirovecii Pneumonia in Patients with Nephrotic Syndrome: Application of Lymphocyte Subset Analysis in Predicting Clinical Outcomes

Canadian Journal of Infectious Diseases and Medical Microbiology, 2020
Purpose. With immunosuppressants being widely used, Pneumocystis jirovecii pneumonia (PCP) has been increasing and could be life-threatening among HIV-negative patients. This study aimed at identifying prognostic factors of PCP in patients with nephrotic
Yang Liu, Ke Zheng, Yecheng Liu, Huadong Zhu   +3 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Comparison of Standard and Point-of-Care CD4+ T Lymphocyte Measurement Methods in HIV-1 Infected Turkish Patients

Medicina
Background and Objectives: CD4+ T lymphocytes are the primary targets of HIV infection. CD4+ T lymphocyte count is an indicator of immune competence. In this study, we aimed to compare standard flow cytometry and point-of-care (POC) CD4+ T lymphocyte in ...
Müge Toygar Deniz, Sıla Akhan, Murat Sayan, Sibel Balcı   +3 more
doaj   +1 more source

The predictive role of lymphocyte subsets and laboratory measurements in COVID-19 disease: a retrospective study

Therapeutic Advances in Respiratory Disease, 2021
Aim: The aim of this study was to investigate the predictive role of lymphocyte subsets and other laboratory measurements in patients with COVID-19.
Lin Wang, Jun Chen, Jun Zhao, Feng Li, Shuihua Lu, Ping Liu, Xu-hui Liu, Qin Huang, He Wang, Qing nian Xu, Xiaomin Liu, Shijun Yu, Li Liu, Hongzhou Lu   +13 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Associação entre a carga viral e os linfócitos T CD4+ com as lesões intra-epiteliais do colo uterino em mulheres infectadas pelo vírus da imunodeficiência humana Association between viral load and CD4+ T lymphocyte count and cervical intraepithelial lesions in HIV-infected women

Revista Brasileira de Ginecologia e Obstetrícia, 2005
OBJETIVOS: verificar se a contagem de linfócitos T CD4+ e a carga viral do HIV têm influência na presença de lesões intra-epiteliais cervicais (SIL). MÉTODOS: estudo transversal, no qual foram selecionadas 134 mulheres HIV-positivas, todas submetidas à ...
Angela Cristina Labanca de Araújo, Victor Hugo de Melo, Lúcia Porto Fonseca de Castro, Mark Drew Crosland Guimarães, Agdemir Waléria Aleixo, Maria Luiza Silva   +5 more
doaj   +1 more source

Evaluating total lymphocyte count as a surrogate marker for CD4 cell count in the management of HIV-infected patients in resource-limited settings: a study from China. [PDF]

PLoS ONE, 2013
OBJECTIVE: To evaluate the correlation of total lymphocyte count (TLC) and CD4 cell count and the suitability of TLC as a surrogate marker for CD4 cell count of HIV-infected patients in China.
Jieqing Chen, Wei Li, Xiaojie Huang, Caiping Guo, Ran Zou, Qiuying Yang, Hongwei Zhang, Tong Zhang, Hui Chen, Hao Wu   +9 more
doaj   +1 more source

Microfluidic Assays for CD4 T Lymphocyte Counting: A Review

Biosensors
CD4 T lymphocytes play a key role in initiating the adaptive immune response, releasing cytokines that mediate numerous signal transduction pathways across the immune system. Therefore, CD4 T cell counts are widely used as an indicator of overall immunological health. HIV, one of the leading causes of death in the developing world, specifically targets
Zhuolun Meng, Hassan Raji, Mahtab Kokabi, Deng Zou, James Chan, Qihao Liu, Ruifeng Zhang, Mehdi Javanmard   +7 more
openaire   +3 more sources