Results 31 to 40 of about 410,730 (244)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
CD40 ligand stimulation affects the number and memory phenotypes of human peripheral CD8+ T cells
BMC Immunology, 2023 Background CD40L is primarily expressed on activated CD4+ T cells and binds to CD40 which is expressed by various cells including dendritic cells, macrophages and B lymphocytes.
Haeyoun Choi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Journal of Translational Medicine, 2020 Background During early pregnancy, tolerance of the semi-allogeneic fetus necessitates comprehensive modifications of the maternal immune system. How decidual CD8+T (CD8+dT) cells balance maternal tolerance of the fetus with defense from invading ...
Lu Liu +8 more
doaj +1 more source
生物医学转化, 2022 CD8+T cell exhaustion is one of the most important reasons for the low response rate of immunotherapy. In the tumor microenvironment(TME), tumor cells preferentially utilize metabolic reprogramming such as aerobic glycolysis to get an advantage on ...
Zhong Jiaxin, Lin Xiaorong, Hu Hai
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
PLoS ONE, 2020 We investigated the phenotype and molecular signatures of CD8+ T cell subsets in kidney-transplant recipients (KTRs) with biopsy-proven T cell-mediated rejection (TCMR).
Eun Jeong Ko +9 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Research and Reports in Tropical Medicine, 2020 Joseph Baruch Baluku,1– 3 Joseph Musaazi,4 Rose Mulwana,1 Araali Robert Mugabo,1 Felix Bongomin,5 Winceslaus Katagira3 1Mulago National Referral Hospital, Pulmonology Division, Kampala, Uganda; 2Mildmay Uganda, Kampala, Uganda; 3Makerere University
Baluku JB +5 more
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Frontiers in Immunology, 2016 Altered T-cell homeostasis, such as expansion of CD8+ T cells to the secondary lymphatic compartments has been suggested as a mechanism of HIV/SIV-pathogenesis.
Jinbiao Liu +12 more
doaj +1 more source