Results 41 to 50 of about 552,193 (236)

Skewed distribution of IL-7 receptor-α-expressing effector memory CD8+ T cells with distinct functional characteristics in oral squamous cell carcinoma.

PLoS ONE, 2014
CD8(+) T cells play important roles in anti-tumor immunity but distribution profile or functional characteristics of effector memory subsets during tumor progression are unclear.
Jang-Jaer Lee, Chiou-Yueh Yeh, Chiau-Jing Jung, Ching-Wen Chen, Mao-Kuang Du, Hui-Ming Yu, Chia-Ju Yang, Hui-Yi Lin, Andy Sun, Jenq-Yuh Ko, Shih Jung Cheng, Yen-Liang Chang, Jean-San Chia   +12 more
doaj   +1 more source

CD40 ligand stimulation affects the number and memory phenotypes of human peripheral CD8+ T cells

BMC Immunology, 2023
Background CD40L is primarily expressed on activated CD4+ T cells and binds to CD40 which is expressed by various cells including dendritic cells, macrophages and B lymphocytes.
Haeyoun Choi, Hyun-Joo Lee, Hyun-Jung Sohn, Tai-Gyu Kim   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Priming of CD8+ T cell responses following immunization with heat-killed Plasmodium sporozoites.

, 2006
Protective immune responses against malaria are induced by immunization with radiation-attenuated Plasmodium sporozoites. In contrast, non-viable, heat-killed sporozoites do not induce protection, emphasizing the requirement for live parasites to achieve
Morrot, Alexandre, Rai, Urvashi, Alexandre Morrot, Fidel Zavala, Hafalla, Julius CR, Rodriguez, Ana, Ana Rodriguez, Zavala, Fidel, Urvashi Rai, Dabeiba Bernal-Rubio, Bernal-Rubio, Dabeiba, Julius C. R. Hafalla   +11 more
core   +1 more source

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells [PDF]

, 2012
mTORC1 (mammalian target of rapamycin complex 1) controls transcriptional programs that determine CD8 cytolytic T cell (CTL) fate. In some cell systems, mTORC1 couples phosphatidylinositol-3 kinase (PI3K) and Akt to the control of glucose uptake and ...
Julia Rolf, Sinclair, Linda V., David K. Finlay, Andrey A. Panteleyev, Rolf, Julia, Okkenhaug, Klaus, Klaus Okkenhaug, Doreen A. Cantrell, Cantrell, Doreen A., Rosenzweig, Ella, Jens L. Hukelmann, Feijoo-Carnero, Carmen, Carmen Feijoo-Carnero, Panteleyev, Andrey A., Hukelmann, Jens L., Linda V. Sinclair, Finlay, David K., Ella Rosenzweig   +17 more
core   +2 more sources

Quantitative multiplex immunofluorescence analysis identifies infiltrating PD1+CD8+ and CD8+ T cells as predictive of response to neoadjuvant chemotherapy in breast cancer

Thoracic Cancer, 2020
Background This study aimed to explore the potentially predictive role and dynamic changes of immune checkpoints on T cell subsets in patients with breast cancer receiving neoadjuvant chemotherapies.
Hongling Liang, Hongsheng Li, Zhi Xie, Tianen Jin, Yu Chen, Zhiyi Lv, Xiaojun Tan, Jia Li, Guodong Han, Weixing He, Ni Qiu, Ming Jiang, Jie Zhou, Haoming Xia, Yongtao Zhan, Lulu Cui, Weiling Guo, Jianqing Huang, Xuchao Zhang, Yi‐long Wu   +19 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Phenotype and molecular signature of CD8+ T cell subsets in T cell- mediated rejections after kidney transplantation.

PLoS ONE, 2020
We investigated the phenotype and molecular signatures of CD8+ T cell subsets in kidney-transplant recipients (KTRs) with biopsy-proven T cell-mediated rejection (TCMR).
Eun Jeong Ko, Jung-Woo Seo, Kyoung Woon Kim, Bo-Mi Kim, Jang-Hee Cho, Chan-Duck Kim, Junhee Seok, Chul Woo Yang, Sang-Ho Lee, Byung Ha Chung   +9 more
doaj   +1 more source

Decidual CD8+T cells exhibit both residency and tolerance signatures modulated by decidual stromal cells

Journal of Translational Medicine, 2020
Background During early pregnancy, tolerance of the semi-allogeneic fetus necessitates comprehensive modifications of the maternal immune system. How decidual CD8+T (CD8+dT) cells balance maternal tolerance of the fetus with defense from invading ...
Lu Liu, Xixi Huang, Chunfang Xu, Chunqin Chen, Weijie Zhao, Dajin Li, Liping Li, Li Wang, Meirong Du   +8 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source