Results 121 to 130 of about 629,825 (307)

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Cold Atmospheric Plasma‐Activated Decellularized Extracellular Matrix Gel as a Tumor‐Infiltrating Immunoactivation Platform for Post‐Surgical Cancer Immunotherapy

Advanced Materials, EarlyView.
An injectable cold atmospheric plasma‐activated decellularized tumor extracellular matrix hydrogel is introduced as a post‐surgical immunoactivation platform. The engineered gel attracts residual tumor cells and induces immunogenic cell death, reshaping the tumor microenvironment and eliciting systemic antitumor immunity. In combination with checkpoint
Tianxu Fang, Mo Chen, Yueyang Deng, Tianqin Ning, Tianwen Luo, Guojun Chen   +5 more
wiley   +1 more source

LFA-1/ICAM-1 Interactions Between CD8⁺ and CD4⁺ T Cells Promote CD4⁺ Th1-Dominant Differentiation and CD8⁺ T Cell Cytotoxicity for Strong Antitumor Immunity After Cryo-Thermal Therapy

Cells
CD4+ T cells have been well-regarded as “helper” cells in activating the cytotoxicity of CD8+ T cells for effective tumor eradication, while few studies have focused on whether CD8+ T cells regulate CD4+ T cells.
Yichen Yao, Zelu Zhang, Shicheng Wang, Junjun Wang, Yuankai Hao, Ke Wang, Ping Liu   +6 more
doaj   +1 more source

Matrix Viscoelasticity Regulates Dendritic Cell Migration and Immune Priming

Advanced Materials, EarlyView.
Matrix viscoelasticity is a key mechanical feature of the tumor microenvironment but remains poorly understood in immune regulation. Here, we develop a tunable collagen platform to decouple viscoelasticity from stiffness and show that slow‐relaxing matrices constrain dendritic cell migration by limiting actomyosin‐driven matrix remodeling, thereby ...
Wei‐Hung Jung, Emie Humann, Joshua M. Price, Yoav Binenbaum, Azra Haseki, Sanjana Iyer, David J. Mooney   +6 more
wiley   +1 more source

Intrahepatic CD161hiCD8+T Cell Recruitment Has a Pathogenetic Potential in Chronic HBV Infection

Immunity, Inflammation and Disease
Backgrounds and Aims CD8+T cells are crucially associated with the fight against hepatitis B virus (HBV) infection. CD161 has been shown to express remarkably on HCV‐specific CD8+T cells.
Jianfei Li, Qian Liu, Wanlu Duan, Zhi Duan, Futing Liu, Mengqi Ruan, Qiyin Zong, Hao Zhang, Qiang Zhou, Qin Wang   +9 more
doaj   +1 more source

Longitudinal Intra- and Inter-individual variation in T-cell subsets of HIV-infected and uninfected men participating in the LA Multi-Center AIDS Cohort Study. [PDF]

, 2019
To assess the intra-individual and inter-individuals biological variation and the effect of aging on lymphocyte T-cells subsets.We assessed lymphocyte phenotypes (CD3, CD4, and CD8 T-cells) in 89 HIV-1-infected and 88 uninfected white non-Hispanic men ...
Aziz, Najib, Chow, Marianne, Detels, Roger, Jamieson, Beth D, Martinez-Maza, Otoniel, Quint, Joshua J   +5 more
core  

CD8+ T cells cure without killing [PDF]

Nature Reviews Immunology, 2019
Mala Maini describes a 1996 paper by Frank Chisari and colleagues that showed CD8+ T cells can exert potent antiviral efficacy against hepatitis B virus without lysing infected cells, through the production of antiviral cytokines.
openaire   +2 more sources

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

Advanced Materials, EarlyView.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou, Yalei Hu, Jie Yu, Naoki Komatsu, Yuta Nishina, Alberto Bianco   +5 more
wiley   +1 more source

Activin A promoted the anti‐tumor effect of ActRIIA high CD8+ T cells in mouse hepatoma

Cancer Medicine
Background Activin A, a noteworthy member of the TGF‐β superfamily. Activin A can regulate the biological functions of various immune cells, such as macrophages, neutrophils, NK cells, etc.
Liangchang Hu, Yu Zhao, Xuguang Zhang, Chunhui Ma   +3 more
doaj   +1 more source

Dynamic analysis of CD127 expression on memory CD8 T cells from patients with chronic hepatitis B during telbivudine treatment

Virology Journal, 2010
Background Accumulating evidence supports the theory that expression of CD127 on CD8 T cells during the process of antiviral immune response indicates a subset of effect CD8 T cells that successfully develop into fully protective memory.
Lv Guocai, Ying Linjung, Ma Wen-Jiang, Jin Xi, Zheng Lin, Li Lanjuan, Yang Yida   +6 more
doaj   +1 more source