Results 141 to 150 of about 1,892,074 (261)

LFA-1/ICAM-1 Interactions Between CD8⁺ and CD4⁺ T Cells Promote CD4⁺ Th1-Dominant Differentiation and CD8⁺ T Cell Cytotoxicity for Strong Antitumor Immunity After Cryo-Thermal Therapy

Cells
CD4+ T cells have been well-regarded as “helper” cells in activating the cytotoxicity of CD8+ T cells for effective tumor eradication, while few studies have focused on whether CD8+ T cells regulate CD4+ T cells.
Yichen Yao, Zelu Zhang, Shicheng Wang, Junjun Wang, Yuankai Hao, Ke Wang, Ping Liu   +6 more
doaj   +1 more source

Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation [PDF]

, 2007
TCR signal strength is involved in many cell fate decisions in the T-cell lineage. Here, we show that transcriptional events induced by Hedgehog (Hh) signaling reduced TCR signal strength in mice.
Drakopoulou, E, Rowbotham, NJ, Crompton, T, Dyson, J, Shah, DK, Cebecauer, M, Hager-Theodorides, AL, Outram, SV   +7 more
core  

CD8 T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4 T Cells <200 Cell/μL: The DART Trial STI Substudy. [PDF]

, 2011
Objective. To better understand attributes of ART-associated HIV-induced T-cell responses that might be therapeutically harnessed. Methods. CD8(+) T-cell responses were evaluated in some HIV-1 chronically infected participants of the fixed duration STI ...
Mugaba, Susan, Walker, S, Sarah Walker, Auma Betty, Paula Munderi, Jennifer Serwanga, Betty, Auma, Edward Pimego, Walker, Ann, Walker, Sarah, Serwanga, J, Pimego, Edward, Serwanga, Jennifer, Frances Gotch, Kaleebu, Pontiano, Munderi, P, Pontiano Kaleebu, Pimego, E, Mugaba, S, Heiner Grosskurth, Kaleebu, P, Gilks, Charles, Munderi, Paula, Grosskurth, H, Betty, A, Gilks, C, Susan Mugaba, Gotch, Frances, Gotch, F, Grosskurth, Heiner, Charles Gilks   +30 more
core   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Intrahepatic CD161hiCD8+T Cell Recruitment Has a Pathogenetic Potential in Chronic HBV Infection

Immunity, Inflammation and Disease
Backgrounds and Aims CD8+T cells are crucially associated with the fight against hepatitis B virus (HBV) infection. CD161 has been shown to express remarkably on HCV‐specific CD8+T cells.
Jianfei Li, Qian Liu, Wanlu Duan, Zhi Duan, Futing Liu, Mengqi Ruan, Qiyin Zong, Hao Zhang, Qiang Zhou, Qin Wang   +9 more
doaj   +1 more source

Pre-existing intratumoral stem-like CD8+ T cells drive radiotherapy-induced tumor immunity

Cell Reports
Summary: CD8+ T cells are crucial for both spontaneous and therapy-induced restriction of tumor progression. Although many patients with cancer undergo radiotherapy, the precise effect of this genotoxic treatment on tumor-associated CD8+ T cells is ...
Hakan Köksal, Michael Herbst, Paulo Perreira, Marc Nater, Nicola Regli, Cheïma Boudjeniba, Nese Erdem Borgoni, Virginia Cecconi, Maries van den Broek   +8 more
doaj   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Membrane‐Bound Multimodal Plasmonic Transducers for Noninvasive, In Situ Monitoring and Control of CAR T Cells Against Heterogeneous Solid Tumors

Advanced Materials, EarlyView.
Membrane‐bound multimodal transducers enable longitudinal ultrasound‐guided photoacoustic monitoring and in situ thermal control of CAR T cells in heterogeneous solid tumors. Imaging correlates T cell trafficking with tumor response, distinguishing responders from nonresponders.
Myeongsoo Kim, Ali Zamat, Melissa Cadena, Chloé Thiveaud, Riya Sen, Jeungyoon Lee, Elif Kulaksizoglu, S. Abbey Oliver, Don VanderLaan, Sydney Fábrega, Zizhen Zha, Kelsey P. Kubelick, Jinhwan Kim, Gabriel A. Kwong, Stanislav Y. Emelianov   +14 more
wiley   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

Nature, 2021
M. Dudek, D. Pfister, Sainitin Donakonda, P. Filpe, A. Schneider, M. Laschinger, D. Hartmann, N. Hüser, Philippa Meiser, F. Bayerl, Donato Inverso, Jennifer Wigger, M. Sebode, R. Öllinger, R. Rad, S. Hegenbarth, M. Anton, A. Guillot, A. Bowman, Danijela Heide, Florian Müller, P. Ramadori, V. Leone, C. García-Cáceres, Tim Gruber, G. Seifert, A. Kabat, Jan-Philipp Mallm, S. Reider, M. Effenberger, S. Roth, A. Billeter, B. Müller-Stich, E. Pearce, F. Koch-Nolte, Rafael Käser, H. Tilg, R. Thimme, Tobias Boettler, F. Tacke, J. Dufour, D. Haller, P. Murray, R. Heeren, D. Zehn, Jan P. Böttcher, Mathias F. Heikenwälder, P. Knolle   +47 more
semanticscholar   +1 more source