Results 81 to 90 of about 1,892,074 (261)

CD8⁺ T Cells in Atherosclerosis

Cells, 2020
Atherosclerotic lesions are populated by cells of the innate and adaptive immune system, including CD8+ T cells. The CD8+ T cell infiltrate has recently been characterized in mouse and human atherosclerosis and revealed activated, cytotoxic, and possibly
Sarah Schäfer, Alma Zernecke
doaj   +1 more source

CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen:Implications for parasite strain-specific immunity [PDF]

, 2009
Although immunodominance of CD8(+) T-cell responses is a well-recognised feature of viral infections, its role in responses to more antigenically complex pathogens is less clear.
Connelley, T., Burrells, A, W. Ivan Morrison, Declan J. McKeever, Connelley, Timothy, Taracha, Evans L., Connelly, T, McKeever, DJ, Morrison, WI, Simon P. Graham, Burrells, A., MacHugh, ND, McKeever, D J, Taracha, E.L.N., Niall D. MacHugh, Roger Pelle, Ellis, SA, McKeever, Declan J., MacHugh, N D, Connelley, T, Evans L. Taracha, Ellis, S A, Graham, SP, Pelle, Roger, Ellis, Shirley A., MacHugh, Niall D., Formisano, Principia, Formisano, P, Principia Formisano, Taracha, EL, Ellis, S.A., Shirley A. Ellis, Taracha, E L, Alison Burrells, Pelle, R, IAH, Graham, Simon P., Graham, S P, Timothy Connelley, Formisano, P., Royal (Dick) School of Veterinary Studies, ILRI, Morrison, W. Ivan, Burrells, Alison, Graham, S.P.   +44 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection.

PLoS Pathogens, 2016
During chronic HIV infection, viral replication is concentrated in secondary lymphoid follicles. Cytotoxic CD8 T cells control HIV replication in extrafollicular regions, but not in the follicle.
Brodie Miles, Shannon M Miller, Joy M Folkvord, David N Levy, Eva G Rakasz, Pamela J Skinner, Elizabeth Connick   +6 more
doaj   +1 more source

Activation or exhaustion of CD8+ T cells in patients with COVID-19

Cellular & Molecular Immunology, 2021
In addition to CD4+ T cells and neutralizing antibodies, CD8+ T cells contribute to protective immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID-19), an ongoing pandemic disease.
Min-Seok Rha, E. Shin
semanticscholar   +1 more source

Oligoclonal expansions of CD8(+) T cells in chronic HIV infection are antigen specific [PDF]

, 1998
Acute HIV infection is associated with a vigorous immune response characterized by the proliferation of selected T cell receptor V beta (BV)-expressing CD8(+) T cells.
Ogg, GS, Christopher A. O'Callaghan, Philip J.R. Goulder, O'Callaghan, CA, Allen, RL, Anthony Kelleher, Andy K. Sewell, Rowland-Jones, Sarah, Jamie D.K. Wilson, Kelleher, A, Mcmichael, Andrew, Goulder, PJ, Andrew J. McMichael, O'Callaghan, Christopher, Graham S. Ogg, Rachel L. Allen, Rowland-Jones, SL, Callan, MF, Wilson, JD, Sarah L. Rowland-Jones, Margaret F.C. Callan, Sewell, AK, McMichael, AJ   +22 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Low and High CD8 Positive T cells in Multiple Sclerosis Patients

Iranian Journal of Allergy, Asthma and Immunology, 2013
Cumulating evidence points to a key role for CD8+ T cells in the pathogenesis of multiple sclerosis.CD8 expression level was believed to be present constantly on the surface of human peripheral blood T cells.
Maryam Izad, Mohammad Hossein Harirchian, Hamed Amiri, Farangis Najafi, Zahra Ghaflati, Zahra Salehi   +5 more
doaj  

Characterization of human cytomegalovirus peptide-specific CD8⁺ T-cell repertoire diversity following in vitro restimulation by antigen-pulsed dendritic cells [PDF]

, 2002
Under conditions of impaired T-cell immunity, human cytomegalovirus (HCMV) can reactivate from lifelong latency, resulting in potentially fatal disease.
Moss, Paul; id_orcid, Karl Peggs, Moss, P, Pizzey, A, Stephanie Verfuerth, Ainsworth, Jennifer, Peggs, K, Verfuerth, S, Mackinnon, S, Ainsworth, J, Paul Moss, Stephen Mackinnon, Jenni Ainsworth, Arnold Pizzey   +13 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source