Results 61 to 70 of about 1,892,074 (261)

Characterization of CD8 T cell responses in Mycobacterium Tuberculosis infection [PDF]

, 2011
The aim of this project was to compare the breadth and magnitude of CFP10 and ESAT6-specific CD8 T cell responses in individuals with latent Mycobacterium tuberculosis (MTB) infection (LTBI) and active TB disease, and further define MTB-specific CD8 T ...
Moshi, Noell Dominika
core   +1 more source

CD40L Expression Allows CD8+ T Cells to Promote Their Own Expansion and Differentiation through Dendritic Cells

Frontiers in Immunology, 2017
CD8+ T cells play an important role in providing protective immunity against a wide range of pathogens, and a number of different factors control their activation.
Neil Q. Tay, Neil Q. Tay, Neil Q. Tay, Debbie C. P. Lee, Debbie C. P. Lee, Yen Leong Chua, Yen Leong Chua, Nayana Prabhu, Nayana Prabhu, Nicholas R. J. Gascoigne, Nicholas R. J. Gascoigne, David M. Kemeny, David M. Kemeny   +12 more
doaj   +1 more source

HIV-1-Specific CD11c+ CD8+ T Cells Display Low PD-1 Expression and Strong Anti-HIV-1 Activity

Frontiers in Immunology, 2021
Exhaustion of HIV-1-specific CD8+ T cells prevents optimal control of HIV-1 infection. Identifying unconventional CD8+ T cell subsets to effectively control HIV-1 replication is vital. In this study, the role of CD11c+ CD8+ T cells during HIV-1 infection
An-Liang Guo, An-Liang Guo, Jin-Fang Zhao, Lin Gao, Lin Gao, Hui-Huang Huang, Ji-Yuan Zhang, Chao Zhang, Jin-Wen Song, Ruo-Nan Xu, Xing Fan, Ming Shi, Yan-Mei Jiao, Fu-Sheng Wang   +13 more
doaj   +1 more source

Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

bioRxiv, 2021
T cell exhaustion is a major impediment to anti-tumor immunity. However, it remains elusive how other immune cells in the tumor microenvironment (TME) contribute to this dysfunctional state.
K. Kersten, K. Hu, A. Combes, B. Samad, Tory Harwin, A. Ray, A. Rao, En Cai, Kyle Marchuk, Jordan Artichoker, T. Courau, Quanming Shi, Julia A. Belk, Ansuman T. Satpathy, M. Krummel   +14 more
semanticscholar   +1 more source

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells [PDF]

, 2012
mTORC1 (mammalian target of rapamycin complex 1) controls transcriptional programs that determine CD8 cytolytic T cell (CTL) fate. In some cell systems, mTORC1 couples phosphatidylinositol-3 kinase (PI3K) and Akt to the control of glucose uptake and ...
Julia Rolf, Sinclair, Linda V., David K. Finlay, Andrey A. Panteleyev, Rolf, Julia, Okkenhaug, Klaus, Klaus Okkenhaug, Doreen A. Cantrell, Cantrell, Doreen A., Rosenzweig, Ella, Jens L. Hukelmann, Feijoo-Carnero, Carmen, Carmen Feijoo-Carnero, Panteleyev, Andrey A., Hukelmann, Jens L., Linda V. Sinclair, Finlay, David K., Ella Rosenzweig   +17 more
core   +2 more sources

Persistent CD8 T Cell Marks Caused by the HCMV Infection in Seropositive Adults: Prevalence of HLA-E-Reactive CD8 T Cells

Cells, 2023
This study investigated the frequency and peptide specificity of long-lasting HCMV-specific CD8 T cells in a cohort of 120 cytomegalovirus seropositive (HCMV+) healthy carriers with the aim of deciphering the relative contribution of unconventional HLA-E-
Amélie Rousselière, Béatrice Charreau
doaj   +1 more source

Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer

Nature, 2021
T cells are important in tumour immunity but a better understanding is needed of the differentiation of antigen-specific T cells in human cancer1,2. Here we studied CD8 T cells in patients with human papillomavirus (HPV)-positive head and neck cancer and
C. Eberhardt, H. Kissick, M. Patel, M. Cardenas, Nataliya Prokhnevska, Rebecca C. Obeng, T. Nasti, Christopher C. Griffith, S. Im, Xu Wang, Dong-Mi Shin, Mary Carrington, Z. Chen, J. Sidney, A. Sette, N. Saba, A. Wieland, R. Ahmed   +17 more
semanticscholar   +1 more source

PD-L1+CD8+ T cells enrichment in lung cancer exerted regulatory function and tumor-promoting tolerance

iScience, 2022
Summary: Immunotherapy targeting checkpoint blockade to rescue T cells from exhaustion has become an essential therapeutic strategy in treating cancers. Till now, little is known about the PD-L1 graphic pattern and characteristics in CD8+ T cells.
Yingxia Zheng, Li Han, Zheyi Chen, Yiyang Li, Bingqian Zhou, Rui Hu, Shiyu Chen, Haibo Xiao, Yanhui Ma, Guohua Xie, Junyao Yang, Xianting Ding, Lisong Shen   +12 more
doaj   +1 more source

An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

Nature, 2019
Tumour-infiltrating lymphocytes are associated with a survival benefit in several tumour types and with the response to immunotherapy1–8. However, the reason some tumours have high CD8 T cell infiltration while others do not remains unclear.
Caroline S. Jansen, Nataliya Prokhnevska, V. Master, M. Sanda, J. Carlisle, M. Bilen, M. Cardenas, S. Wilkinson, Ross Lake, A. Sowalsky, R. Valanparambil, W. Hudson, D. McGuire, K. Melnick, A. I. Khan, K. S. Kim, Yun-Min Chang, Alice Kim, C. Filson, M. Alemozaffar, A. Osunkoya, Patrick Mullane, C. Ellis, Rama S. Akondy, S. Im, A. Kamphorst, A. Reyes, Yuan Liu, H. Kissick   +28 more
semanticscholar   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source