Results 41 to 50 of about 629,825 (307)

PD-L1+CD8+ T cells enrichment in lung cancer exerted regulatory function and tumor-promoting tolerance

iScience, 2022
Summary: Immunotherapy targeting checkpoint blockade to rescue T cells from exhaustion has become an essential therapeutic strategy in treating cancers. Till now, little is known about the PD-L1 graphic pattern and characteristics in CD8+ T cells.
Yingxia Zheng, Li Han, Zheyi Chen, Yiyang Li, Bingqian Zhou, Rui Hu, Shiyu Chen, Haibo Xiao, Yanhui Ma, Guohua Xie, Junyao Yang, Xianting Ding, Lisong Shen   +12 more
doaj   +1 more source

Systematic and Cell Type-Specific Telomere Length Changes in Subsets of Lymphocytes. [PDF]

, 2016
Telomeres, the protective DNA-protein complexes at the ends of linear chromosomes, are important for genome stability. Leukocyte or peripheral blood mononuclear cell (PBMC) telomere length is a potential biomarker for human aging that integrates genetic,
Aschbacher, Kirstin, Blackburn, Elizabeth H, Brown, Rashida, Cheon, Joshua, Coccia, Michael, Epel, Elissa, Lin, Jue, Puterman, Eli, Sinclair, Elizabeth   +8 more
core   +3 more sources

Tissue-Resident Memory-Like CD8+ T Cells Exhibit Heterogeneous Characteristics in Tuberculous Pleural Effusion

Journal of Immunology Research, 2021
Tissue-resident memory T (TRM) cells are well known to play critical roles in peripheral tissues during virus infection and tumor immunology. Our previous studies indicated that CD69+CD4+ and CD69+CD8+ T cells in tuberculous pleural effusion (TPE) were ...
Sifei Yu, Suihua Lao, Binyan Yang, Changyou Wu   +3 more
doaj   +1 more source

HIV-1-Specific CD11c+ CD8+ T Cells Display Low PD-1 Expression and Strong Anti-HIV-1 Activity

Frontiers in Immunology, 2021
Exhaustion of HIV-1-specific CD8+ T cells prevents optimal control of HIV-1 infection. Identifying unconventional CD8+ T cell subsets to effectively control HIV-1 replication is vital. In this study, the role of CD11c+ CD8+ T cells during HIV-1 infection
An-Liang Guo, An-Liang Guo, Jin-Fang Zhao, Lin Gao, Lin Gao, Hui-Huang Huang, Ji-Yuan Zhang, Chao Zhang, Jin-Wen Song, Ruo-Nan Xu, Xing Fan, Ming Shi, Yan-Mei Jiao, Fu-Sheng Wang   +13 more
doaj   +1 more source

Persistent CD8 T Cell Marks Caused by the HCMV Infection in Seropositive Adults: Prevalence of HLA-E-Reactive CD8 T Cells

Cells, 2023
This study investigated the frequency and peptide specificity of long-lasting HCMV-specific CD8 T cells in a cohort of 120 cytomegalovirus seropositive (HCMV+) healthy carriers with the aim of deciphering the relative contribution of unconventional HLA-E-
Amélie Rousselière, Béatrice Charreau
doaj   +1 more source

CD40L Expression Allows CD8+ T Cells to Promote Their Own Expansion and Differentiation through Dendritic Cells

Frontiers in Immunology, 2017
CD8+ T cells play an important role in providing protective immunity against a wide range of pathogens, and a number of different factors control their activation.
Neil Q. Tay, Neil Q. Tay, Neil Q. Tay, Debbie C. P. Lee, Debbie C. P. Lee, Yen Leong Chua, Yen Leong Chua, Nayana Prabhu, Nayana Prabhu, Nicholas R. J. Gascoigne, Nicholas R. J. Gascoigne, David M. Kemeny, David M. Kemeny   +12 more
doaj   +1 more source

Comparison of dynamic changes in the peripheral CD8+ T cells function and differentiation in ESCC patients treated with radiotherapy combined with anti-PD-1 antibody or concurrent chemoradiotherapy

Frontiers in Immunology, 2022
ObjectiveThe systematic immune status of cancer patients undergoing immunotherapy is little known. We prospectively identified the function and differentiation traits of peripheral CD8+ T cells based on our phase 1b clinical trial (NCT03222440) of ...
Hui Wei, Yanqi Li, Zhoubo Guo, Xiaoxue Ma, Yang Li, Xiaoying Wei, Dong Han, Tian Zhang, Xi Chen, Cihui Yan, Jiahuan Zhou, Qingsong Pang, Ping Wang, Wencheng Zhang   +13 more
doaj   +1 more source

HIV-Specific CD8+ T Cells Exhibit Reduced and Differentially Regulated Cytolytic Activity in Lymphoid Tissue

Cell Reports, 2017
Summary: Elimination of lymphoid tissue reservoirs is a key component of HIV eradication strategies. CD8+ T cells play a critical role in control of HIV, but their functional attributes in lymph nodes (LNs) remain unclear.
Morgan A. Reuter, Perla M. Del Rio Estrada, Marcus Buggert, Constantinos Petrovas, Sara Ferrando-Martinez, Son Nguyen, Alberto Sada Japp, Yuria Ablanedo-Terrazas, Amaranta Rivero-Arrieta, Leticia Kuri-Cervantes, Heidi M. Gunzelman, Emma Gostick, David A. Price, Richard A. Koup, Ali Naji, David H. Canaday, Gustavo Reyes-Terán, Michael R. Betts   +17 more
doaj   +1 more source

Early Skewed Distribution of Total and HIV-Specific CD8+ T-Cell Memory Phenotypes during Primary HIV Infection Is Related to Reduced Antiviral Activity and Faster Disease Progression [PDF]

, 2014
The important role of the CD8+ T-cells on HIV control is well established. However, correlates of immune protection remain elusive. Although the importance of CD8+ T-cell specificity and functionality in virus control has been underscored, further ...
Cahn, Pedro, Falivene, Juliana, Gherardi, Maria Magdalena, Ghiglione, Yanina Alexandra, Giavedoni, Luis, Laufer, Natalia Lorna, Ruiz, Maria Julia, Salomon, Horacio Eduardo, Socías, María Eugenia, Sued, Omar Gustavo, Turk, Gabriela Julia Ana   +10 more
core   +1 more source

Cancer immunosurveillance by CD8 T cells [PDF]

F1000Research, 2020
Clinical success attained in patients with cancer treated with checkpoint inhibitors has renewed the interest in the immune system and in particular in T cells as a therapeutic tool to eliminate tumors. Here, we discuss recent studies that evaluate the anti-tumor role of CD8 T cells and the mechanisms that interfere with this function.
José C. Crispín, George C. Tsokos
openaire   +2 more sources