Results 41 to 50 of about 1,892,074 (261)

Natural killer cells promote early CD8 T cell responses against cytomegalovirus. [PDF]

, 2007
Understanding the mechanisms that help promote protective immune responses to pathogens is a major challenge in biomedical research and an important goal for the design of innovative therapeutic or vaccination strategies.
Sacher, Torsten, Ulrich H Koszinowski, Rupp Brigitte, Eric Vivier, Ruzsics, Zsolt, Koszinowski Ulrich H, Cornillon, Amélie, Dalod Marc, Bessou Gilles, Koszinowski, Ulrich H, Marc Dalod, Sacher Torsten, Robbins, Scott H., Torsten Sacher, Tomasello Elena, Dalod, Marc, Scott H Robbins, Nicolas Zucchini, Ruzsics Zsolt, Koszinowski, Ulrich H., Zsolt Ruzsics, Elena Tomasello, Gilles Bessou, Bessou, Gilles, Tomasello, Elena, Cornillon Amélie, Vivier Eric, Vivier, Eric, Zucchini, Nicolas, Amélie Cornillon, Brigitte Rupp, Zucchini Nicolas, Robbins, Scott H, Robbins Scott H, Rupp, Brigitte   +34 more
core   +2 more sources

Sepsis-induced changes in differentiation, maintenance, and function of memory CD8 T cell subsets

Frontiers in Immunology, 2023
Formation of long-lasting memory lymphocytes is one of the foundational characteristics of adaptive immunity and the basis of many vaccination strategies.
Mohammad Heidarian, Thomas S. Griffith, Thomas S. Griffith, Vladimir P. Badovinac, Vladimir P. Badovinac   +4 more
doaj   +1 more source

Dysfunctional CD8+ T cells form a proliferative, dynamically regulated compartment within human melanoma

Cell, 2018
Tumor immune cell compositions play a major role in response to immunotherapy but the heterogeneity and dynamics of immune infiltrates in human cancer lesions remain poorly characterized.
Hanjie Li, A. M. van der Leun, Ido Yofe, Yaniv Lubling, Dikla Gelbard-Solodkin, A. V. van Akkooi, M. van den Braber, E. Rozeman, J. Haanen, C. Blank, Hugo M. Horlings, Eyal David, Yael Baran, A. Bercovich, A. Lifshitz, T. Schumacher, A. Tanay, I. Amit   +17 more
semanticscholar   +1 more source

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity [PDF]

, 2012
Decline of cell-mediated immunity is often attributed to decaying T-cell numbers and their distribution in peripheral organs. This study examined the hypothesis that qualitative as well as quantitative changes contribute to the declining efficacy of CD8+
James P. Hindley, Ann Ager, van den Berg, Hugo A., McLaren, James Edward, Ladell, Kristin Ingrid, Marsden, Morgan, Hindley, James P., Godkin, Andrew, McLaren, James E., Price, D. A., James E. McLaren, Mathew Clement, Bridgeman, Hayley, Ian R. Humphreys, David A. Price, Hindley, James Philip, Gallimore, Awen Myfanwy, Humphreys, Ian R., Linda Wooldridge, Hugo A. van den Berg, Godkin, Andrew James, Clement, Mathew, Ager, Ann, Berg, Hugo van den, Hayley M. Bridgeman, Kristin Ladell, Andrew Godkin, Awen M. Gallimore, Morgan Marsden, Ladell, Kristin, Smart, Kathryn, Price, David, Kathryn Smart, Bridgeman, Hayley M., Wooldridge, Linda, Gallimore, Awen M.   +35 more
core   +1 more source

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

Nature Communications, 2018
Identifying tumor antigen-specific T cells from cancer patients has important implications for immunotherapy diagnostics and therapeutics. Here, we show that CD103+CD39+ tumor-infiltrating CD8 T cells (CD8 TIL) are enriched for tumor-reactive cells both ...
Thomas Duhen, Rebekka Duhen, R. Montler, Jake Moses, T. Moudgil, N. D. de Miranda, C. Goodall, T. Blair, B. Fox, J. Mcdermott, Shu-Ching Chang, G. Grunkemeier, R. Leidner, R. Bell, A. Weinberg   +14 more
semanticscholar   +1 more source

IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites. [PDF]

, 2005
IL-4 receptor (IL-4R)-deficient CD8+ T cells specific for the circumsporozoite protein of Plasmodium yoelii develop a severely impaired memory response after priming with parasites.
Morrot, Alexandre, Alexandre Morrot, Fidel Zavala, Hafalla, Julius CR, Cockburn, Ian A, Carvalho, Luzia H, Zavala, Fidel, Julius C.R. Hafalla, Luzia H. Carvalho, Ian A. Cockburn   +9 more
core   +1 more source

Dichotomous Roles of Programmed Cell Death 1 on HIV-Specific CXCR5+ and CXCR5− CD8+ T Cells during Chronic HIV Infection

Frontiers in Immunology, 2017
BackgroundCXCR5+CD8+ T cells have been demonstrated to play an important role in the control of chronic viral replication; however, the relationship between CXCR5+CD8+ T cells, HIV disease progression, and programmed cell death 1 (PD-1) expression ...
Yan-Mei Jiao, Hong-Ge Yang, Hui-Huang Huang, Bo Tu, Shao-Jun Xing, Lin Mao, Wei Xia, Ran He, Ji-Yuan Zhang, Ruo-Nan Xu, Lei Jin, Ming Shi, Zhe Xu, En-Qiang Qin, Xi-Cheng Wang, Hao Wu, Lilin Ye, Fu-Sheng Wang   +17 more
doaj   +1 more source

Tissue-Resident Memory-Like CD8+ T Cells Exhibit Heterogeneous Characteristics in Tuberculous Pleural Effusion

Journal of Immunology Research, 2021
Tissue-resident memory T (TRM) cells are well known to play critical roles in peripheral tissues during virus infection and tumor immunology. Our previous studies indicated that CD69+CD4+ and CD69+CD8+ T cells in tuberculous pleural effusion (TPE) were ...
Sifei Yu, Suihua Lao, Binyan Yang, Changyou Wu   +3 more
doaj   +1 more source

Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.

Immunity, 1998
Viral infections induce extensive T cell proliferation in vivo, but the specificity of the majority of the responding T cells has not been defined. To address this issue we used tetramers of MHC class I molecules containing viral peptides to directly ...
Kaja Murali-Krishna, J. Altman, M. Suresh, D. Sourdive, A. Zajac, Joseph D. Miller, J. Slansky, R. Ahmed   +7 more
semanticscholar   +1 more source

A reservoir of stem-like CD8+ T cells in the tumor-draining lymph node preserves the ongoing anti-tumor immune response

Science immunology, 2021
Description Tumor-specific CD8+ T cells in stable tumor-draining lymph node reservoir are clonally and developmentally related to those in tumors. A niche in the node The presence of “stem-like” TCF1+ CD8+ T (TSL) cells in tumors correlates with better ...
K. Connolly, Manik Kuchroo, Aarthi Venkat, Achia Khatun, Jiawei Wang, I. William, N. Hornick, B. Fitzgerald, M. Damo, Moujtaba Y. Kasmani, Can Cui, Eric Fagerberg, I. Monroy, A. Hutchins, Julie F. Cheung, Gena G. Foster, Dylan L. Mariuzza, M. Nader, Hongyu Zhao, W. Cui, Smita Krishnaswamy, N. Joshi   +21 more
semanticscholar   +1 more source