Results 41 to 50 of about 524,942 (303)

Persistent CD8 T Cell Marks Caused by the HCMV Infection in Seropositive Adults: Prevalence of HLA-E-Reactive CD8 T Cells

Cells, 2023
This study investigated the frequency and peptide specificity of long-lasting HCMV-specific CD8 T cells in a cohort of 120 cytomegalovirus seropositive (HCMV+) healthy carriers with the aim of deciphering the relative contribution of unconventional HLA-E-
Amélie Rousselière, Béatrice Charreau
doaj   +1 more source

Early self-regulatory mechanisms control the magnitude of CD8+ T cell responses against liver stages of murine malaria. [PDF]

, 2003
Following immunization with Plasmodium yoelii sporozoites, the CD8(+) T cell population specific for the SYVPSAEQI epitope expressed in sporozoite and liver stages of this malaria parasite revealed the existence of a short term Ag presentation process ...
Morrot, Alexandre, Hafalla, Julius CR, Milon, Geneviève, Lafaille, Juan J, Zavala, Fidel, Sano, Gen-Ichiro   +5 more
core   +1 more source

Phenotype and molecular signature of CD8+ T cell subsets in T cell- mediated rejections after kidney transplantation.

PLoS ONE, 2020
We investigated the phenotype and molecular signatures of CD8+ T cell subsets in kidney-transplant recipients (KTRs) with biopsy-proven T cell-mediated rejection (TCMR).
Eun Jeong Ko, Jung-Woo Seo, Kyoung Woon Kim, Bo-Mi Kim, Jang-Hee Cho, Chan-Duck Kim, Junhee Seok, Chul Woo Yang, Sang-Ho Lee, Byung Ha Chung   +9 more
doaj   +1 more source

Sepsis-induced changes in differentiation, maintenance, and function of memory CD8 T cell subsets

Frontiers in Immunology, 2023
Formation of long-lasting memory lymphocytes is one of the foundational characteristics of adaptive immunity and the basis of many vaccination strategies.
Mohammad Heidarian, Thomas S. Griffith, Thomas S. Griffith, Vladimir P. Badovinac, Vladimir P. Badovinac   +4 more
doaj   +1 more source

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells [PDF]

, 2012
mTORC1 (mammalian target of rapamycin complex 1) controls transcriptional programs that determine CD8 cytolytic T cell (CTL) fate. In some cell systems, mTORC1 couples phosphatidylinositol-3 kinase (PI3K) and Akt to the control of glucose uptake and ...
Julia Rolf, Sinclair, Linda V., David K. Finlay, Andrey A. Panteleyev, Rolf, Julia, Okkenhaug, Klaus, Klaus Okkenhaug, Doreen A. Cantrell, Cantrell, Doreen A., Rosenzweig, Ella, Jens L. Hukelmann, Feijoo-Carnero, Carmen, Carmen Feijoo-Carnero, Panteleyev, Andrey A., Hukelmann, Jens L., Linda V. Sinclair, Finlay, David K., Ella Rosenzweig   +17 more
core   +2 more sources

Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes [PDF]

, 1990
Although the relative contribution of different immune effector functions to clearing tissues of cytomegalovirus is controversial, the contribution of CD8+ T lymphocytes has generally been accepted as essential. In this report, we show that under certain
Pavic, Ivica, Koszinowski, Ulrich H., Lucin, Pero, Rukavina, Daniel, Jonjic, Stipan   +4 more
core   +2 more sources

Tissue-Resident Memory-Like CD8+ T Cells Exhibit Heterogeneous Characteristics in Tuberculous Pleural Effusion

Journal of Immunology Research, 2021
Tissue-resident memory T (TRM) cells are well known to play critical roles in peripheral tissues during virus infection and tumor immunology. Our previous studies indicated that CD69+CD4+ and CD69+CD8+ T cells in tuberculous pleural effusion (TPE) were ...
Sifei Yu, Suihua Lao, Binyan Yang, Changyou Wu   +3 more
doaj   +1 more source

IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages.

, 2002
CD4+ T cells are crucial to the development of CD8+ T cell responses against hepatocytes infected with malaria parasites. In the absence of CD4+ T cells, CD8+ T cells initiate a seemingly normal differentiation and proliferation during the first few days
Morrot, Alexandre, Gen-ichiro Sano, Alexandre Morrot, Maria A. Curotto de Lafaille, Fidel Zavala, Hafalla, Julius CR, Carvalho, Luzia H, Curotto de Lafaille, Maria A, Zavala, Fidel, Luzia H. Carvalho, Julius C.R. Hafalla, Sano, Gen-Ichiro   +11 more
core   +1 more source

IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites. [PDF]

, 2005
IL-4 receptor (IL-4R)-deficient CD8+ T cells specific for the circumsporozoite protein of Plasmodium yoelii develop a severely impaired memory response after priming with parasites.
Morrot, Alexandre, Alexandre Morrot, Fidel Zavala, Hafalla, Julius CR, Cockburn, Ian A, Carvalho, Luzia H, Zavala, Fidel, Julius C.R. Hafalla, Luzia H. Carvalho, Ian A. Cockburn   +9 more
core   +1 more source

A Subset of CXCR5+CD8+ T Cells in the Germinal Centers From Human Tonsils and Lymph Nodes Help B Cells Produce Immunoglobulins

Frontiers in Immunology, 2018
Recent studies indicated that CXCR5+CD8+ T cells in lymph nodes could eradicate virus-infected target cells. However, in the current study we found that a subset of CXCR5+CD8+ T cells in the germinal centers from human tonsils or lymph nodes are ...
Juan Shen, Xi Luo, Qiongli Wu, Jun Huang, Guanying Xiao, Liantang Wang, Binyan Yang, Huabin Li, Changyou Wu   +8 more
doaj   +1 more source