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Inflaming the CD8+ T Cell Response [PDF]
Immunity, 2006 Although inflammatory cytokines induced by infection or vaccination with adjuvants have long been known to stimulate optimal antigen-presenting cell function, recent evidence indicates that some inflammatory cytokines also act directly on the responding T cells to control their response to infection.
Haring, Jodie S. +2 more
openaire +2 more sources
Swift development of protective effector functions in naive CD8(+) T cells against malaria liver stages. [PDF]
, 2001 We generated T cell receptor transgenic mice specific for the liver stages of the rodent malaria parasite Plasmodium yoelii and studied the early events in the development of in vivo effector functions in antigen-specific CD8(+) T cells.
Lafaille, JJ +11 more
core +1 more source
The Timing of Stimulation and IL-2 Signaling Regulate Secondary CD8 T Cell Responses. [PDF]
PLoS Pathogens, 2015 Memory CD8 T cells provide protection to immune hosts by eliminating pathogen-infected cells during re-infection. While parameters influencing the generation of primary (1°) CD8 T cells are well established, the factors controlling the development of ...
Shaniya H Khan +5 more
doaj +1 more source
Human memory CD8+ T-cells exhibit an intrinsic metabolic advantage as reflected by increased mitochondrial functionality and high glycolytic potential [PDF]
, 2013 Intrinsic differences between na•ve and memory CD8+ T-cells affect both quality and quantity of cognate antigen response. Cellular immune function and metabolic pathways are closely linked.
Gubser, Patrick Marc
core +1 more source
CD8 + T regulatory cells in lupus [PDF]
Rheumatology and Immunology Research, 2021 Abstract T regulatory cells (T regs ) have a key role in the maintenance of immune homeostasis and the regulation of immune tolerance by preventing the inflammation and suppressing the autoimmune responses.
Singh, Ram P. +2 more
openaire +2 more sources
World Journal of Surgical Oncology, 2023 Background Tissue-resident CD8+T cells (CD103+CD8+T cells) are the essential effector cell population of anti-tumor immune response in tissue regional immunity. And we have reported that IL-33 can promote the proliferation and effector function of tissue-
Lujun Chen +11 more
doaj +1 more source
Defining Memory CD8 T Cell [PDF]
Frontiers in Immunology, 2018 CD8 T cells comprising the memory pool display considerable heterogeneity, with individual cells differing in phenotype and function. This review will focus on our current understanding of heterogeneity within the antigen-specific memory CD8 T cell compartment and classifications of memory CD8 T cell subsets with defined and discrete functionalities ...
Matthew D. Martin +3 more
openaire +3 more sources
Molecular signatures distinguish human central memory from effector memory CD8 T cell subsets [PDF]
, 2005 Memory T cells are heterogeneous in terms of their phenotype and functional properties. We investigated the molecular profiles of human CD8 naive central memory (T(CM)), effector memory (T(EM)), and effector memory RA (T(EMRA)) T cells using gene ...
Freeman, Tom +9 more
core +1 more source
Journal of Experimental & Clinical Cancer Research, 2022 CD8+ T cells play a central role in anti-tumor immunity. Naïve CD8+ T cells are active upon tumor antigen stimulation, and then differentiate into functional cells and migrate towards the tumor sites.
Lu Zhang +13 more
doaj +1 more source
Diversity in CD8+ T cell differentiation [PDF]
Current Opinion in Immunology, 2009 CD8(+) T cells are key effector cells of the adaptive immune system, however their activity must be tightly regulated to allow pathogen clearance whilst preventing immunopathology and autoimmunity. In this review, we summarise the diversity of responses that CD8(+) T cells make to antigenic stimulation with a focus on how CD8(+) T cell responses are ...
Parish, Ian, Kaech, Susan
openaire +3 more sources