Results 11 to 20 of about 524,942 (303)

CD8⁺ T Cells in Atherosclerosis [PDF]

Cells, 2020
Atherosclerotic lesions are populated by cells of the innate and adaptive immune system, including CD8+ T cells. The CD8+ T cell infiltrate has recently been characterized in mouse and human atherosclerosis and revealed activated, cytotoxic, and possibly
Sarah Schäfer, Alma Zernecke
doaj   +4 more sources

CD8+ T Cells: GITR Matters

The Scientific World Journal, 2012
As many members of the tumor necrosis factor receptor superfamily, glucocorticoid-induced TNFR-related gene (GITR) plays multiple roles mostly in the cells of immune system.
Simona Ronchetti, Giuseppe Nocentini, Maria Grazia Petrillo, Carlo Riccardi   +3 more
doaj   +4 more sources

CD8+ T Cell Exhaustion in Cancer [PDF]

Frontiers in Immunology, 2021
A paradigm shift in the understanding of the exhausted CD8 + T cell (T ex ) lineage is underway. Originally thought to be a uniform population that progressively loses effector function in response to persistent antigen, single-cell analysis has now ...
Joseph S. Dolina, Natalija Van Braeckel-Budimir, Graham D. Thomas, Shahram Salek-Ardakani   +3 more
openaire   +3 more sources

Stem-like CD8+ T cells in cancer

Frontiers in Immunology
Stem-like CD8+ T cells (TSL) are a subset of immune cells with superior persistence and antitumor immunity. They are TCF1+ PD-1+ and important for the expansion of tumor specific CD8+ T cells in response to checkpoint blockade immunotherapy.
Chelsea Steiner, Nathan Denlinger, Xiaopei Huang, Yiping Yang   +3 more
doaj   +3 more sources

CD8 T cell quiescence revisited [PDF]

Trends in Immunology, 2012
Naïve T cells are typically considered to be in a default state of quiescence, whereas memory T cells undergo basal proliferation and quickly exhibit effector responses when stimulated. Over the past few years, however, a more complex picture has emerged, with evidence that naïve T cell quiescence is actively enforced, and that heterogeneity among ...
Sara E, Hamilton, Stephen C, Jameson
openaire   +2 more sources

Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with Hepatitis B virus infection [PDF]

, 2005
CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell responses of patients with chronic and resolved ...
Gotto, J, Ornella Franzese, Antonio Bertoletti, Maini, Mk, Franzese, O., Williams, R., Adam J. Gehring, Gehring, A.J., Roger Williams, Gehring, Aj, Gotto, J., Bertoletti, A., Kennedy, P.T.F., Williams, R, Maini, M.K., Patrick T. F. Kennedy, Kennedy, Ptf, Jim Gotto, Mala K. Maini, FRANZESE, ORNELLA   +19 more
core   +1 more source

Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection. [PDF]

, 2011
During human and murine cytomegalovirus (MCMV) infection an exceptionally large virus-specific CD8 T cell pool is maintained in the periphery lifelong.
Torti, Nicole, Oxenius, Annette, Walton, Senta M., Walton Senta M., Rülicke Thomas, Senta M Walton, Torti Nicole, Oxenius Annette, Brocker, Thomas, Senta M. Walton, Rülicke, Thomas, Nicole Torti, Brocker Thomas, Thomas Brocker, Thomas Rülicke, Annette Oxenius, Oxenius A, Torti N, Brocker T, Rülicke T, Walton SM   +20 more
core   +2 more sources

Cancer immunosurveillance by CD8 T cells [PDF]

F1000Research, 2020
Clinical success attained in patients with cancer treated with checkpoint inhibitors has renewed the interest in the immune system and in particular in T cells as a therapeutic tool to eliminate tumors. Here, we discuss recent studies that evaluate the anti-tumor role of CD8 T cells and the mechanisms that interfere with this function.
José C. Crispín, George C. Tsokos
openaire   +2 more sources

Splenic CD8(+) T cells secrete TGF-beta 1 to exert suppression in mice with anterior chamber-associated immune deviation [PDF]

, 2009
Background CD8(+) regulatory T cells (Treg) have been considered to be involved in a model of ocular-induced tolerance, known as anterior chamber-associated immune deviation (ACAID).
Hao He, Lin, X.M., Peizeng Yang, Jiang, L.Q., Hongyan Zhou, Aize Kijlstra, Liqiong Jiang, Huang, X.K., Yang, P.Z., He, H., Zhou, H.Y., Xiaomin Lin, Xiangkun Huang, Kijlstra, A.   +13 more
core   +1 more source

Intratumoral CXCL13+CD8+T cell infiltration determines poor clinical outcomes and immunoevasive contexture in patients with clear cell renal cell carcinoma

Journal for ImmunoTherapy of Cancer, 2021
Background Chemokine (C-X-C motif) ligand 13 (CXCL13) was known as a selective chemotaxis for B cells, a product of follicular helper CD4+T cells (TFH) and a contributor to tertiary lymphoid structures (TLS).
Jiejie Xu, Yu Xia, Ying Xiong, Yu Zhu, Zewei Wang, Han Zeng, Zhaopei Liu, Jiajun Wang, Yuan Chang, Le Xu, Qi Bai, Jianming Guo, Siyuan Dai, Kaifeng Jin, Wenbin Jiang, Zhiyuan Lin, Yang Qu   +16 more
doaj   +1 more source