Results 11 to 20 of about 1,892,074 (261)

Uptake of oxidized lipids from the tumor microenvironment by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8 T cells

Immunity, 2021
SUMMARY A common metabolic alteration in the tumor microenvironment (TME) is lipid accumulation, a feature associated with immune dysfunction. Here we examined how CD8+ tumor infiltrating lymphocytes (TILs) respond to lipids within the TME.
Shihao Xu, O. Chaudhary, Patricia Rodríguez-Morales, Xiao-Li Sun, Dan Chen, R. Zappasodi, Zi-Yan Xu, Antonio F. M. Pinto, April E Williams, Isabell Schulze, Yagmur Farsakoglu, S. Varanasi, J. Low, Wenxi Tang, Haiping Wang, Bryan McDonald, V. Tripple, M. Downes, R. Evans, N. Abumrad, T. Merghoub, J. Wolchok, M. Shokhirev, Ping-Chih Ho, J. Witztum, B. Emu, Guoliang Cui, S. Kaech   +27 more
semanticscholar   +1 more source

Cytotoxic CD8+ T cells in cancer and cancer immunotherapy

British Journal of Cancer, 2020
The functions of, and interactions between, the innate and adaptive immune systems are vital for anticancer immunity. Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of
H. Raskov, A. Orhan, J. Christensen, I. Gögenur   +3 more
semanticscholar   +1 more source

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

Nature Immunology, 2020
The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery from COVID-19 (28 with mild disease and 14 ...
Yanchun Peng, A. Mentzer, Guihai Liu, X. Yao, Z. Yin, D. Dong, W. Dejnirattisai, T. Rostron, P. Supasa, Chang Liu, C. López-Camacho, J. Slon-Campos, Yuguang Zhao, D. Stuart, G. Paesen, J. Grimes, A. Antson, O. Bayfield, D. E. Hawkins, D. Ker, Beibei Wang, L. Turtle, Krishanthi S Subramaniam, Paul J. Thomson, Ping Zhang, C. Dold, J. Ratcliff, P. Simmonds, T. D. de Silva, P. Sopp, D. Wellington, U. Rajapaksa, Yi-Ling Chen, M. Salio, G. Napolitani, Wayne Paes, P. Borrow, B. Kessler, J. Fry, N. Schwabe, M. Semple, J. Baillie, S. Moore, P. Openshaw, M. Ansari, S. Dunachie, Ellie Barnes, J. Frater, G. Kerr, P. Goulder, T. Lockett, R. Levin, Yonghong Zhang, R. Jing, L. Ho, R. Cornall, C. Conlon, P. Klenerman, G. Screaton, J. Mongkolsapaya, A. McMichael, J. Knight, G. Ogg, Tao Dong   +63 more
semanticscholar   +1 more source

CD8+ T cells in the Cancer Immunity Cycle

Immunity, 2023
CD8+ T cells are end effectors of cancer immunity. Most forms of effective cancer immunotherapy involve CD8+ T cell cytotoxic function. Here we review the current understanding of T cell function in cancer, focusing on key CD8+ T cell subtypes and states.
Josephine R. Giles, A. Globig, S. Kaech, E. Wherry   +3 more
semanticscholar   +1 more source

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

Nature, 2020
Alzheimer’s disease is an incurable neurodegenerative disorder in which neuroinflammation has a critical function1. However, little is known about the contribution of the adaptive immune response in Alzheimer’s disease2.
D. Gate, N. Saligrama, Olivia Leventhal, Andrew C. Yang, M. S. Unger, J. Middeldorp, Kelly S. Chen, B. Lehallier, D. Channappa, Mark B. De Los Santos, Alisha Mcbride, J. Pluvinage, Fanny M. Elahi, G. Tam, Yongha Kim, M. Greicius, A. Wagner, L. Aigner, D. Galasko, Mark M. Davis, T. Wyss-Coray   +20 more
semanticscholar   +1 more source

Non-hematopoietic cells in lymph nodes drive memory CD8 T cell inflation during murine cytomegalovirus infection. [PDF]

, 2011
During human and murine cytomegalovirus (MCMV) infection an exceptionally large virus-specific CD8 T cell pool is maintained in the periphery lifelong.
Torti, Nicole, Oxenius, Annette, Walton, Senta M., Walton Senta M., Rülicke Thomas, Senta M Walton, Torti Nicole, Oxenius Annette, Brocker, Thomas, Senta M. Walton, Rülicke, Thomas, Nicole Torti, Brocker Thomas, Thomas Brocker, Thomas Rülicke, Annette Oxenius   +15 more
core   +2 more sources

CD8+ T cells regulate tumor ferroptosis during cancer immunotherapy

Nature, 2019
Cancer immunotherapy restores or enhances the effector function of CD8+ T cells in the tumour microenvironment1,2. CD8+ T cells activated by cancer immunotherapy clear tumours mainly by inducing cell death through perforin–granzyme and Fas–Fas ligand ...
Weimin Wang, M. Green, J. E. Choi, M. Gijón, Paul D. Kennedy, Jeffrey K. Johnson, P. Liao, Xueting Lang, Ilona Kryczek, Amanda Sell, Houjun Xia, Jiajia Zhou, Gao-Peng Li, Jing Li, Wei Li, Shuang Wei, Linda Vatan, Hongjuan Zhang, Wojciech Szeliga, W. Gu, Rebecca J Liu, T. Lawrence, Candice Lamb, Yuri Tanno, M. Cieslik, Everett M Stone, G. Georgiou, T. Chan, A. Chinnaiyan, W. Zou   +29 more
semanticscholar   +1 more source

The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes.

Cell, 2022
Blocking PD-1/PD-L1 signaling transforms cancer therapy and is assumed to unleash exhausted tumor-reactive CD8+ T cells in the tumor microenvironment (TME).
Qi-Zhao Huang, Xia Wu, Zhiming Wang, Xiangyu Chen, Lisha Wang, Yijun Lu, D. Xiong, Qiao-Yi Liu, Yuhan Tian, Huayu Lin, Junyi Guo, Shuqiong Wen, Wei Dong, Xiaofan Yang, Yuchen Yuan, Zhengliang Yue, Shun Lei, Qing Wu, Ling Ran, Luoyingzi Xie, Yifei Wang, Leiqiong Gao, Qin Tian, Xinyuan Zhou, Beicheng Sun, Li-Fan Xu, Zhonghui Tang, L. Ye   +27 more
semanticscholar   +1 more source

NanoAPC deliver antigen, IL-2 and co-stimulatory molecules to antigen specific T cells and activate viral specific T cells in chronic infections [PDF]

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The study of the immune system has provided insight in the mechanism of protection induced by vaccination; primarily that most clinically protective ...
Liu, Mengya
core   +7 more sources

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

Nature Immunology, 2019
T cell dysfunction is a hallmark of many cancers, but the basis for T cell dysfunction and the mechanisms by which antibody blockade of the inhibitory receptor PD-1 (anti-PD-1) reinvigorates T cells are not fully understood.
Brian C. Miller, Debattama R. Sen, Rose Al Abosy, Kevin Bi, Y. Virkud, M. LaFleur, Kathleen B. Yates, A. Lako, K. Felt, G. S. Naik, M. Manos, E. Gjini, Juhi R. Kuchroo, J. Ishizuka, J. Collier, Gabriel K. Griffin, Seth Maleri, Dawn E Comstock, Sarah A. Weiss, Flavian D. Brown, Arpit Panda, Margaret D. Zimmer, R. Manguso, F. Hodi, S. Rodig, A. Sharpe, W. Haining   +26 more
semanticscholar   +1 more source