Results 31 to 40 of about 524,942 (303)

Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells [PDF]

, 2011
The outcome of viral infections is dependent on the function of CD8+ T cells which are tightly regulated by costimulatory molecules. The NK cell receptor 2B4 (CD244) is a transmembrane protein belonging to the Ig superfamily which can also be expressed ...
Lunemann, Sebastian, Bektas, Hueseyin, Heiner Wedemeyer, Wedemeyer Heiner, Suneetha, Pothakamuri Venkata, Grabowski, Jan, Michael Peter Manns, Markus Cornberg, Sarrazin, Christoph, Julia Dietz, Hueseyin Bektas, Christoph Sarrazin, Helfritz Fabian, Schlaphoff, Verena, Lunemann Sebastian, Fabian Helfritz, Suneetha Pothakamuri Venkata, Dietz, Julia, Jaroszewicz, Jerzy, Wedemeyer, Heiner, Bektas Hueseyin, Sebastian Lunemann, Pothakamuri Venkata Suneetha, Sarrazin Christoph, Manns Michael Peter, Jaroszewicz Jerzy, Jerzy Jaroszewicz, Helfritz, Fabian Arnold, Cornberg, Markus, Jan Grabowski, Schlaphoff Verena, Dietz Julia, Manns, Michael P., Verena Schlaphoff, Grabowski Jan, Cornberg Markus   +35 more
core   +2 more sources

Cytomegalovirus Colitis in Primary Hypogammaglobulinemia With Normal CD4+ T Cells: Deficiency of CMV-Specific CD8+ T Cells

Frontiers in Immunology, 2019
CMV colitis has been reported in immunocompromized patients with severe deficiency of CD4+ T cells and T cell functions. In this study we present an extensive immunological analysis in a patient with primary hypogammaglobulinemia and CMV colitis who had ...
Sudhanshu Agrawal, Amrita Khokhar, Sudhir Gupta   +2 more
doaj   +1 more source

CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection

Cell Reports, 2021
Summary: CD4 T cells are essential for immunity to tuberculosis because they produce cytokines, including interferon-γ. Whether CD4 T cells act as “helper” cells to promote optimal CD8 T cell responses during Mycobacterium tuberculosis is unknown.
Yu-Jung Lu, Palmira Barreira-Silva, Shayla Boyce, Jennifer Powers, Kelly Cavallo, Samuel M. Behar   +5 more
doaj   +1 more source

NanoAPC deliver antigen, IL-2 and co-stimulatory molecules to antigen specific T cells and activate viral specific T cells in chronic infections [PDF]

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The study of the immune system has provided insight in the mechanism of protection induced by vaccination; primarily that most clinically protective ...
Liu, Mengya
core   +7 more sources

CD80 Expressed by CD8+ T Cells Contributes to PD-L1-Induced Apoptosis of Activated CD8+ T Cells

Journal of Immunology Research, 2017
Tumor cells are capable of limiting antitumor CD8+ T cell responses through their cell surface expression of PD-L1. In addition to PD-1 expressed by CD8+ T cells, PD-L1 also binds to CD80 expressed by CD8+ T cells.
Meagan R. Rollins, Rachel M. Gibbons Johnson   +1 more
doaj   +1 more source

A brief history of CD8 T cells [PDF]

European Journal of Immunology, 2007
CD8 T cells comprise a powerful branch of the adaptive immune system, yet were not formally recognized until long after the discovery of antibody. CD8 T cells contribute to the eradication of intracellular infections and to the control of many chronic infections.
David, Masopust, Vaiva, Vezys, E John, Wherry, Rafi, Ahmed   +3 more
openaire   +2 more sources

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity [PDF]

, 2012
Decline of cell-mediated immunity is often attributed to decaying T-cell numbers and their distribution in peripheral organs. This study examined the hypothesis that qualitative as well as quantitative changes contribute to the declining efficacy of CD8+
James P. Hindley, Ann Ager, van den Berg, Hugo A., McLaren, James Edward, Ladell, Kristin Ingrid, Marsden, Morgan, Hindley, James P., Godkin, Andrew, McLaren, James E., Price, D. A., James E. McLaren, Mathew Clement, Bridgeman, Hayley, Ian R. Humphreys, David A. Price, Hindley, James Philip, Gallimore, Awen Myfanwy, Humphreys, Ian R., Linda Wooldridge, Hugo A. van den Berg, Godkin, Andrew James, Clement, Mathew, Ager, Ann, Berg, Hugo van den, Hayley M. Bridgeman, Kristin Ladell, Andrew Godkin, Awen M. Gallimore, Morgan Marsden, Ladell, Kristin, Smart, Kathryn, Price, David, Kathryn Smart, Bridgeman, Hayley M., Wooldridge, Linda, Gallimore, Awen M.   +35 more
core   +1 more source

Interleukin-7 regulates CD127 expression and promotes CD8+ T cell activity in patients with primary cutaneous melanoma

BMC Immunology, 2022
Background Interleukin (IL)-7 signaling through CD127 is impaired in lymphocytes in cancers and chronic infections, resulting in CD8+ T cell exhaustion. The mechanisms underlying CD8+ T cell responses to IL-7 in melanoma remain not completely elucidated.
Hongxia He, Binjun Qiao, Shuping Guo, Hongzhou Cui, Ziyan Zhang, Junxia Qin   +5 more
doaj   +1 more source

HIV-1-Specific CD11c+ CD8+ T Cells Display Low PD-1 Expression and Strong Anti-HIV-1 Activity

Frontiers in Immunology, 2021
Exhaustion of HIV-1-specific CD8+ T cells prevents optimal control of HIV-1 infection. Identifying unconventional CD8+ T cell subsets to effectively control HIV-1 replication is vital. In this study, the role of CD11c+ CD8+ T cells during HIV-1 infection
An-Liang Guo, An-Liang Guo, Jin-Fang Zhao, Lin Gao, Lin Gao, Hui-Huang Huang, Ji-Yuan Zhang, Chao Zhang, Jin-Wen Song, Ruo-Nan Xu, Xing Fan, Ming Shi, Yan-Mei Jiao, Fu-Sheng Wang   +13 more
doaj   +1 more source

Dichotomous Roles of Programmed Cell Death 1 on HIV-Specific CXCR5+ and CXCR5− CD8+ T Cells during Chronic HIV Infection

Frontiers in Immunology, 2017
BackgroundCXCR5+CD8+ T cells have been demonstrated to play an important role in the control of chronic viral replication; however, the relationship between CXCR5+CD8+ T cells, HIV disease progression, and programmed cell death 1 (PD-1) expression ...
Yan-Mei Jiao, Hong-Ge Yang, Hui-Huang Huang, Bo Tu, Shao-Jun Xing, Lin Mao, Wei Xia, Ran He, Ji-Yuan Zhang, Ruo-Nan Xu, Lei Jin, Ming Shi, Zhe Xu, En-Qiang Qin, Xi-Cheng Wang, Hao Wu, Lilin Ye, Fu-Sheng Wang   +17 more
doaj   +1 more source