Results 151 to 160 of about 436,454 (294)

Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules. [PDF]

, 1989
Hung‐Sia Teh, Hiroyuki Kishi, B Scott, Harald von Boehmer   +3 more
openalex   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Targeting the N-acetyltransferase 10/DKK2 axis enhances CD8+ T cell antitumor activity in colorectal cancer models. [PDF]

J Clin Invest
Li M, Zhao X, Wu J, Zhou S, Fu Y, Chen C, Ma Z, Xu J, Qian Y, Wang Z, Wang B, Wang Q, Ding Q, Chen C, Wang H, Yang X, Dai W, Zhang W, Wang S.   +18 more
europepmc   +1 more source

FcγRIIIa is a noncanonical costimulatory molecule for CD8 T cells [PDF]

Kevin S. Kao, Nicole Loren Pihlstrom, Emily G. Niejadlik, Tineke Cantaert, Rafi Ahmed, Jeffrey V. Ravetch, Stylianos Bournazos   +6 more
openalex   +1 more source

Vaccination with a Fusion Protein That Introduces HIV-1 Gag Antigen into a Multitrimer CD40L Construct Results in Enhanced CD8 ⁺ T Cell Responses and Protection from Viral Challenge by Vaccinia-Gag [PDF]

, 2013
Sachin Gupta, James M. Termini, Francesca Raffa, Cindi-Ann Williams, Richard S. Kornbluth, Geoffrey W. Stone   +5 more
openalex   +1 more source

YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination

Advanced Science, EarlyView.
The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu, Wenzhi Du, Yongwen Luo, Jiageng Shi, Tianyun Liu, Meng Ji, Kangping Xiong, Siming Chen, Fenfang Zhou, Mingxing Li, Jingtian Yu, Gang Wang, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Kaiyu Qian   +16 more
wiley   +1 more source

Decorin facilitates T cell-mediated antitumor immunity and augments the efficacy of anti-PD1 immunotherapy. [PDF]

Cancer Immunol Immunother
Zheng N, Xiang L, Xu G, Liu Y, Xu C, Zhang L, Zuo Y, Ye Z, Liu Y, Yang Z.   +9 more
europepmc   +1 more source

Induction of Antiviral Antibodies by DNA Immunization Requires neither Perforin-Mediated nor CD8⁺-T-Cell-Mediated Lysis of Antigen-Expressing Cells [PDF]

, 1999
Daniel E. Hassett, Jie Zhang, J. Lindsay Whitton   +2 more
openalex   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

The orphan nuclear receptor NR4A3 is dispensable for resident memory CD8+ T-cell generation. [PDF]

Immunohorizons
Odagiu L, Boulet S, De Sousa DM, Daudelin JF, Labrecque N.   +4 more
europepmc   +1 more source