Results 171 to 180 of about 419,552 (297)

Emodin Alleviates Sepsis‐Induced Multiorgan Damage by Inhibiting NETosis through Targeting Neutrophils BCL‐10

Advanced Science, EarlyView.
Emodin targets BCL‐10 to modulate the BCL‐10/MALT1 complex, thereby suppressing NF‐κB activation and significantly exerting multiorgan protective effects in sepsis. Abstract Sepsis is a life‐threatening condition caused by dysregulated host responses to infection, characterized by excessive inflammation and abnormal coagulation.
Xiaolong Xu, Yumeng Yan, Meiling Zheng, Mina Zhang, Tengfei Chen, Zhicheng Qu, Yinglu Bai, Shuwen Zhang, Chunming Zhao, Yifan Shi, Yan Lin, Ning Wang, Yunjing Bai, Yating Zhai, Zhaofang Bai, Wei Guo, Qingquan Liu   +16 more
wiley   +1 more source

Dengue virus-specific cross-reactive CD8+ human cytotoxic T lymphocytes

, 1989
Jack F. Bukowski, I Kurane, C J Lai, M Bray, Barry Falgout, F A Ennis   +5 more
openalex   +1 more source

Correlation between CD8 dependency and determinant density using peptide-induced, Ld-restricted cytotoxic T lymphocytes. [PDF]

, 1991
M Alexander, Cheryl A Damico, K Wieties, Ted H. Hansen, J M Connolly   +4 more
openalex   +1 more source

Neuron-reactive KIR⁺CD8⁺ T cells display an encephalitogenic transcriptional program in autoimmune encephalitis. [PDF]

Nat Commun
Perriot S, Jones S, Genolet R, Mathias A, Lindsay H, Bobisse S, Di Liberto G, Canales M, Queiroz L, Sauvage C, Wagner I, Oberholster L, Gimenez M, Bégarie D, Kovac S, Desestret V, Théaudin M, Pot C, Wiendl H, Honnorat J, Merkler D, Gottardo R, Harari A, Du Pasquier R.   +23 more
europepmc   +1 more source

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, EarlyView.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source

An HLA-C-restricted CD8+ cytotoxic T-lymphocyte clone recognizes a highly conserved epitope on human immunodeficiency virus type 1 gag [PDF]

, 1991
R A Littaua, Michael B. A. Oldstone, Atsushi Takeda, Christine Debouck, Johnson T. Wong, Carmelita U. Tuazon, Bernard Moss, Femia Kievits, Francis A. Ennis   +8 more
openalex   +1 more source

CD8⁺ T cells in allergy [PDF]

Allergy, 1992
B. J. Holmes, D. M. Kemeny, D Diaz-Sanchez   +2 more
openaire   +3 more sources

Increased Peripheral T Stem Cell-like Memory Features in Patients with Advanced Solid Tumors Treated with Tumor-Targeting IL-12 Immunocytokine Therapy. [PDF]

Clin Cancer Res
Goswami M, Celades C, Minnar CM, Khelifa AS, Poppe LK, Bracken-Clarke D, Toney NJ, Lynch MT, Marté JL, Gameiro SR, Gulley JL, Schlom J, Donahue RN.   +12 more
europepmc   +1 more source

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients

Advanced Science, EarlyView.
scRNA sequencing reveals distinct tumor ecosystem features in CAYA‐PTC, marked by enriched CD4T_Tfh, CD8T_Tex cells, and rapid malignant thyrocyte differentiation (absent of mild‐state BRAF‐like population) toward invasive states. Prominent emCAF_LAMP5 populations interact with endothelial cells and thyrocytes facilitate angiogenesis and metastasis ...
Kai Guo, Lingyi Yang, Zirui Huang, Kai Qian, Yuan Shi, Mengjia Fei, Yuan Feng, Zixian Chen, Ming Qiu, Linglin Tang, Anqi Li, Zhibao Lv, Jiangbin Liu, Zhou Chen, Kuiran Dong, Zhuoying Wang   +15 more
wiley   +1 more source

Fc gamma RII/III and CD2 expression mark distinct subpopulations of immature CD4-CD8- murine thymocytes: in vivo developmental kinetics and T cell receptor beta chain rearrangement status. [PDF]

, 1993
Hans-Reimer Rodewald, K Awad, Philippe Moingeon, Luciano D'adamio, David S. Rabinowitz, Yoichi Shinkai, F W Alt, Ellis L. Reinherz   +7 more
openalex   +1 more source