Results 261 to 270 of about 394,438 (273)

Silk Fibroin Nanoparticles for Enhanced Cuproptosis and Immunotherapy in Pancreatic Cancer Treatment

Advanced Science, EarlyView.
Cuproptosis can be triggered via intracellular copper overload mediated by elesclomol (ES).Enhancing ES‐Cu's tumor targeting and circulation stability can efficiently induce tumor cuproptosis. TSF@ES‐Cu protect ES‐Cu, target tumors via natural RGD sequences, and release through multi‐responsiveness.
Si Gao, Haodong Ge, Lili Gao, Ying Gao, Shuibin Tang, Yiming Li, Zhiqing Yuan, Wei Chen   +7 more
wiley   +1 more source

CaMKK2 Regulates Macrophage Polarization Induced by Matrix Stiffness: Implications for Shaping the Immune Response in Stiffened Tissues

Advanced Science, EarlyView.
Macrophage phenotypes are influenced by the microenvironment. Matrix stiffness, a key ECM factor, polarizes macrophage toward a pro‐regenerative phenotype in a 3D physiological environment. CaMKK2 selectively regulates stiffness‐induced macrophage polarization, impacting tumor growth and wound healing.
Ya Guan, Min Zhang, Jiyeon Song, Marcos Negrete, Tyler Adcock, Reeva Kandel, Luigi Racioppi, Sharon Gerecht   +7 more
wiley   +1 more source

Targeting Antigen‐Presenting Cells to Enhance the Tumor‐Spleen Immunity Cycle through Liposome‐Neoantigen Vaccine

Advanced Science, EarlyView.
LNPsD18, a cationic liposome that enhances antigen‐presenting cell uptake in the spleen and tumor without targeting ligands is developed. Co‐delivering neoantigens and a TLR9 agonist significantly improve DC activation, tumor immunity, and survival in liver and colorectal cancer models, demonstrating the importance of dual‐site APC targeting for cancer
Yu Xu, Bing Wang, Yue Huang, JianPing Liao, Chenyi Wu, Chenxi Zhou, Zishi Kang, Shiyang Jiang, Bing‐Chen Wu, Da Zhang, Ruihua Xu, Xiaolong Liu, Feng Wang   +12 more
wiley   +1 more source

Novel immunodominant neoepitope in a KPC mouse model of pancreatic cancer allowing identification of tumor-specific T cells. [PDF]

Oncoimmunology
Antsiferova M, Berrera M, Zagdoun AC, Raauf M, Nguyen TT, Murgia C, Appelt B, Trumpfheller C, Gasser S, Pilet S, Nicolini V, de Matos IG.   +11 more
europepmc   +1 more source

KK2DP7 Stimulates CD11b+ Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

Advanced Science, EarlyView.
This study introduces KK2DP7, a dendrimer‐structured peptide adjuvant, as a tool to decode trained immunity's role in antitumor therapy. Splenic CD11b+ cells mediate tumor suppression via TLR2‐IRF7 activation and epigenetic reprogramming, validated by adoptive transfer experiments.
Rui Zhang, Lin Tang, Yusi Wang, Xuejing Zhou, Zhenyu Ding, Li Yang   +5 more
wiley   +1 more source

Effector CD8 T cell differentiation in primary and breakthrough SARS-CoV-2 infection in mice. [PDF]

Commun Biol
Kingstad-Bakke B, Lee W, Yount BL, Cleven T, Park H, Sullivan JA, Baric RC, Suresh M.   +7 more
europepmc   +1 more source

Patients with Cervical Cancer with and without HIV Infection Have Unique T-cell Activation Profiles despite Similar Survival Outcomes after Chemoradiation. [PDF]

Cancer Res Commun
MacDuffie EC, Cocka L, Lin X, Bvochora-Nsingo M, Chiyapo S, Balang D, Maswabi B, Ngoni K, Ramogola-Masire D, Zetola NM, Wei Z, Shen H, Bassa S, Grover S, Robertson ES.   +14 more
europepmc   +1 more source

Orchestrating T and NK cells for tumor immunotherapy via NKG2A-targeted delivery of a de novo designed IL-2Rβγ agonist. [PDF]

Drug Deliv
Chen J, Ren E, Tao Z, Lu H, Huang Y, Li J, Chen Y, Chen Z, She T, Yang H, Zhu H, Lu X.   +11 more
europepmc   +1 more source

Prognostic significance of cytotoxic-T-lymphocytes to immunosuppressive lymphocytes ratio (CIL) in laryngeal squamous cell carcinoma. [PDF]

Cancer Immunol Immunother
Zhang D, Heng Y, Jin QY, Tang D, Zhu XK, Lu LM, Wu CP, Tao L.   +7 more
europepmc   +1 more source

CCR8 antagonist suppresses liver cancer progression via turning tumor-infiltrating Tregs into less immunosuppressive phenotype. [PDF]

J Exp Clin Cancer Res
Tian B, Wang Z, Cao M, Wang N, Jia X, Zhang Y, Zhou J, Liu S, Zhang W, Dong X, Li Z, Xue J, Wang J, Fan GH, Li Q.   +14 more
europepmc   +1 more source