Results 261 to 270 of about 419,552 (297)

Unveiling altered CD8 T-cell metabolism and homeostatic proliferation behind a low CD4/CD8 ratio in ART-suppressed HIV individuals with normal CD4 recovery. [PDF]

Front Immunol
Garrido-Rodríguez V, Bulnes-Ramos Á, Olivas-Martínez I, Pozo-Balado MDM, Tejerina-Picado F, Gutiérrez F, Marco-Sánchez C, Tiraboschi JM, Castillo-Navarro A, Bernal E, Garcia-Guerrero MC, Puertas MC, Peraire J, Rull A, Martinez-Picado J, Pacheco YM.   +15 more
europepmc   +1 more source

Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes

Advanced Science, EarlyView.
This study uses a high‐resolution DNA methylation reference panel for 19 immune cell‐types, as well as transcriptomic, metabolomic, and large population cohort data to show that age‐related epigenetic heterogeneity within monocytes correlates with inflammaging, biological age, and all‐causemortality, and does so more strongly than existing monocyte ...
Xiaolong Guo, Josephine A. Robertson, Andrea Aparicio, Kirsten Seale, Qingwen Chen, Anne Richmond, Zhaozhen Du, Mahnoor Sulaiman, Shijie C Zheng, Esteban Ballestar, Charlotte AM Cecil, Bastiaan T Heijmans, Steve Horvath, Varun B. Dwaraka, Jessica Lasky‐Su, Ryan Smith, Riccardo E. Marioni, Andrew E Teschendorff   +17 more
wiley   +1 more source

Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR‐NFκB Pathway

Advanced Science, EarlyView.
This study demonstrates that vinburnine, an approved cerebrovascular drug, synergizes with radiotherapy in nasopharyngeal carcinoma (NPC) by modulating EDAR‐NFκB signaling through directly binding to EDAR, leading to triggering apoptosis/pyroptosis, and amplifying CCL5/CX3CL1‐driven T‐cell cytotoxicity.
Jing Chen, Nian Liu, Qian Tao, Jie Wu, Jinyu Huang, Can Lu, Qiuqiu Li, Liangfang Shen, Xiang Chen, Cong Peng   +9 more
wiley   +1 more source

Lack of immunogenicity for an influenza-derived peptide across the HLA-B44 supertype molecules. [PDF]

Clin Transl Immunology
Leong SL, Maddumage JC, Gras S, Grant EJ.   +3 more
europepmc   +1 more source

Disruption of NF‐κB‐Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis

Advanced Science, EarlyView.
This study reveals a feedback mechanism regulating copper homeostasis, in which copper directly interacts with TAK1 to activate NF‐κB signaling, while NF‐κB transcriptionally suppresses copper transporter (CTR1) expression. These findings highlight a promising therapeutic strategy for breast cancer by combining NF‐κB inhibitors with copper chelators or
Xiaomei Zhang, Yaqing Su, Weixiong Yang, Zimin Song, Zicheng Sun, Xueji Wu, Jianwen Chen, Bing Gao, Zekang Wang, Lei Wang, Qiwei Jiang, Lang Bu, Jingting Li, Ying Lin, Wei Xie, Jie Li, Jianping Guo   +16 more
wiley   +1 more source

PD1/PDL1 and TIM3/Gal9 expression in acute lymphoblastic leukemia: Gal-9 expression on leukemia stem cells as an independent prognostic parameter. [PDF]

BMC Cancer
Kamel AM, Almuslimani AM, Kandil EZ, Hanafy M, Samra MA, Madney YM, Osman RA.   +6 more
europepmc   +1 more source

CXCR1 Depletion in Ly6C+ cDC2 Alleviates Acute Lung Injury via Modulation of Th17/Treg Balance

Advanced Science, EarlyView.
Pro‐inflammatory Ly6C⁺ cDC2s are identified as key effector cells mediating Cxcr1 signaling, driving the progression of ALI. Ly6C⁺ cDC2s release high levels of Il‐6 and Il‐1β, inducing Th17 differentiation. Cxcr1 deficiency reduces Il‐6 and Il‐1β production from Ly6C⁺ cDC2s through suppressing MEK1/ERK /NF‐κB signaling, thereby shifts naïve T cells ...
Shenghui Li, Wei Zhuang, Yang Wang, Hao Qin, Xichun Qin, Xianliang Yan, Xuefei Hu, Xiucheng Liu, Chang Chen   +8 more
wiley   +1 more source

Immunosenescence phenotypes and prognostic significance of CD8 + CD28- T cells in AIDS-related non-Hodgkin lymphoma. [PDF]

Ann Med
Kang Z, Tao X, Wu S, Chu S, Peng J, Chen J.   +5 more
europepmc   +1 more source

CD8 T cell exhaustion-associated LncRNA signature reveals novel molecular subtypes and immune targets in hepatocellular carcinoma. [PDF]

Discov Oncol
Feng J, Yan D, Jiang L, Song F.
europepmc   +1 more source