Results 261 to 270 of about 922,724 (383)

Targeted Expansion of Treg Cells to Induce Immune Tolerance after Kidney Transplantation

Advanced Science, EarlyView.
A dual‐targeting nanoparticle platform that selectively engages graft stromal cells via CD248 receptors while employing kidney‐ specific promoters (NPHS2) to drive localized IL‐ 2/TGF‐βexpression is developed. This approach achieves three therapeutic objectives:1) intragraft Treg polarization without systemic cytokine exposure;2) reduced dependence on ...
Tong Lu, Hongtao Song, Limin He, Zhihao Hu, Yu Li, Chao Xu, Shaojie Liu, Jun Jiang, Yike Zhou, Zhengxuan Li, Zeyu Li, Keying Zhang, Shuaijun Ma, Ruochen Qi, Shichao Han, Changhong Shi, Weihong Wen, Donghui Han, Weijun Qin   +18 more
wiley   +1 more source

Exploratory Immunohistochemical Profiling of FOXP3, PD-1 and CD32B in Resectable Lung Adenocarcinoma. [PDF]

Cancers (Basel)
Lin LW, Chuang HJ, Lian KH, Tseng YT, Chen CY.   +4 more
europepmc   +1 more source

Imbalance between subsets of CD8 ⁺ peripheral blood T cells in patients with chronic obstructive pulmonary disease

, 2016
Long Chen, Gang Chen, Mingqiang Zhang, Xian‐Zhi Xiong, Hongju Liu, Jian‐Bao Xin, Jianchu Zhang, Jianghua Wu, Zhao‐Ji Meng, Sheng‐Wen Sun   +9 more
openalex   +1 more source

A Novel Zinc(II) Complex for Sonodynamic Therapy Induces Pyroptosis of Breast Cancer Cells and Enhances Anti‐Tumor Immune Response

Advanced Science, EarlyView.
Although Zinc(II) complexes are effective in photodynamic therapy, their efficacy is limited by the poor tissue penetration of light. This work introduces a novel zinc(II) complex for sonodynamic therapy. Under ultrasound activation, it generates substantial singlet oxygen, induces pyroptosis in breast cancer cells, and promotes anti‐tumor immune ...
Sijie Wen, Dongsheng Tang, Lingpu Zhang, Hanchen Zhang, Zheng Cao, Kong Wai Tan, Xiaojun Wang, Haihua Xiao, Kun Shang   +8 more
wiley   +1 more source

Migration of CD8 + TSCM cells into intestine via PPBP-CXCR2 axis increases host stress susceptibility by inhibiting gut microbiome-derived homovanillic acid. [PDF]

Nat Commun
Zhang Y, Ju M, Chen S, Yang W, Cai Y, Yu X, Chen G, Shen Z, Bai Y, Ren H, Li Y, Shen L, Li J, Shi P, Yuan Y, Han B, Yao H.   +16 more
europepmc   +1 more source

Exploration of Novel Biomarkers Through a Precision Medicine Approach Using Multi‐Omics and Brain Organoids in Patients With Atypical Depression and Psychotic Symptoms

Advanced Science, EarlyView.
This study examines major depressive disorder with atypical features and psychotic symptoms through a multi‐omics precision medicine approach. By integrating clinical assessments, WBC scRNA‐seq, plasma proteomics, and brain organoid models, it uncovers immune dysregulation, synaptic protein alterations, and stress‐sensitive neuronal changes.
Insook Ahn, Soyeon Chang, Jiyoung Lee, Seok‐Ho Choi, Jinju Han, Yangsik Kim   +5 more
wiley   +1 more source

High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures. [PDF]

Nat Commun
Cabug AF, Crawford JC, McQuilten HA, Foo IJH, Allen LF, Gebregzabher D, Mettelman RC, Novak T, Chou J, Rowntree LC, Hagen RR, Thomson AJ, Martin GE, Gilbertson B, Souter MN, James F, Goodall E, Rizzetto S, Flerlage T, Jia X, Van de Velde LA, Chang SY, Luciani F, Thwaites RS, Trubiano JA, Kotsimbos TC, Cheng AC, Randolph AG, Thomas PG, Xu J, Wang Z, Nguyen THO, Chua BY, Kedzierski L, Kedzierska K.   +34 more
europepmc   +1 more source

Three‐Year Follow‐Up of Neoadjuvant Tislelizumab with Chemotherapy in Locally Advanced Gastric and Gastroesophageal Junction Adenocarcinoma: Revealing Cancer‐Associated Fibroblast Heterogeneity Corresponding to PD‐1 Blockade Efficacy

Advanced Science, EarlyView.
Heterogeneous cancer‐associated fibroblasts orchestrate dual immune microenvironments in LAGC. Abstract The potential for immunotherapy in patients with locally advanced gastric cancer (LAGC) is recently confirmed. To report the 3‐year follow‐up data are aimed from a novel clinical trial. This is a prospective single‐arm phase II trial.
Yao Lin, Xiong Sun, Chengguo Li, Ming Yang, Ke Wu, Ke Liu, Anshu Li, Xiaoming Shuai, Kailin Cai, Zheng Wang, Guobin Wang, Peng Zhang, Jianfeng Shen, Kaixiong Tao, Yuping Yin   +14 more
wiley   +1 more source

A comprehensive longitudinal analysis of the cellular immune response specific to the spike protein in healthcare workers vaccinated against SARS-CoV-2- ORCHESTRA Project. [PDF]

Front Immunol
Ugel S, Gupta A, Spiteri G, Marchetti P, De Sanctis F, Wouters S, Konnova A, Monaco MGL, Carta A, Pezzani MD, Liviero F, Pavanello S, dell'Omo M, Fabiánová E, Bérešová J, Larese Filon F, Mauro M, Verlato G, Bronte V, Kumar-Singh S, Porru S.   +20 more
europepmc   +1 more source

Ficolin-2 triggers antitumor and anti-pathogen effects by activating antigen presenting cells and CD8+T cells [PDF]

, 2017
Xiao‐Lian Zhang
openalex   +1 more source