Results 281 to 290 of about 922,724 (383)

Pomalidomide enhances CD8⁺ T and NK cell mediated killing of HIV-infected cells. [PDF]

EBioMedicine
Pascoe RD, Gubser C, Chang JJ, Schröder J, Utzschneider DT, Barrow A, Lee WS, McMahon JH, Chiu CY, Solomon A, Anderson J, Lewin SR, Rasmussen TA.   +12 more
europepmc   +1 more source

One CD4+TCR and One CD8+TCR Targeting Autochthonous Neoantigens Are Essential and Sufficient for Tumor Eradication

Steven P. Wolf, Vasiliki Anastasopoulou, Kimberley Drousch, Markus I. Diehl, Boris Engels, Poh Yin Yew, Kazuma Kiyotani, Yusuke Nakamura, Karin Schreiber, Hans Schreiber, Matthias Leisegang   +10 more
openalex   +2 more sources

Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1–targeted therapy in lung cancer patients

Proceedings of the National Academy of Sciences of the United States of America, 2017
A. Kamphorst, R. Pillai, Shu Yang, T. Nasti, Rama S. Akondy, A. Wieland, G. Sica, Ke Yu, Lydia Koenig, N. Patel, M. Behera, Hong Wu, M. Mccausland, Zhengjia Chen, Chao Zhang, F. Khuri, T. Owonikoko, R. Ahmed, S. Ramalingam   +18 more
semanticscholar   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

KIAA1429 impairs anti-tumor immunity via regulation of PD-L1 and CD8⁺ T cells in colorectal cancer. [PDF]

Sci Rep
Du Y, Liu Y, Wang M, Wang Y, Lin M.
europepmc   +1 more source

CircLRBA Promotes Epithelial‐Mesenchymal Transition, Immune Evasion, Chemoimmunotherapy Resistance and Metastasis Through Stabilizing Twist1

Advanced Science, EarlyView.
CircLRBA is highly expressed in breast cancer (BC) and associated with poor overall survival. Zeb1 mediated circLRBA facilitates BC cell proliferation, invasion, docetaxel (DTX) resistance and inhibits the infiltration of CD8+ T cell. CircLRBA could combine with SPOP to suppress the Twist1 ubiquitination degradation and enhances PD‐L1 transcription ...
Xiaosong Wang, Xin Yang, Lei Xing, Hang Chen, Fuming Xie, Bin Wang, Bowen Shi, Yan Yang, Junxia Chen   +8 more
wiley   +1 more source

CD8 T cells are dispensable for experimental autoimmune prostatitis induction and chronic pelvic pain development [PDF]

Florencia C. Salazar, Maria Santos Martínez, Daniela Andrea Paira, Yair A. Chocobar, Carolina Olivera, Gloria J. Godoy, Eva V. Acosta Rodríguez, Virginia E. Rivero, Rubén D. Motrich   +8 more
openalex   +1 more source

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, EarlyView.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source

Dual blockades of TIM-3 and PD-1 effectively prevent hyper-progression and enhance the efficacy of anti-PD-1 therapy in high-grade serous ovarian cancer. [PDF]

Cell Death Dis
Li J, Zhou Y, Song Y, Dai G, Li X, Sun Y, Wang J, Wei R, Li F, Xi L.   +9 more
europepmc   +1 more source

Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer.

Proceedings of the National Academy of Sciences of the United States of America, 2005
E. Sato, S. Olson, Jiyoung Ahn, B. Bundy, H. Nishikawa, F. Qian, A. Jungbluth, D. Frosina, S. Gnjatic, C. Ambrosone, J. Kepner, Tosin Odunsi, G. Ritter, S. Lele, Yao-Tseng Chen, H. Ohtani, L. Old, K. Odunsi   +17 more
semanticscholar   +1 more source