Results 281 to 290 of about 419,552 (297)
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Science Immunology, 2023
Iterative acute stimulations can maintain CD8 T cells for longer than their organismal lifespan.
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Iterative acute stimulations can maintain CD8 T cells for longer than their organismal lifespan.
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AIDS Research and Human Retroviruses, 1999
The distribution and function of lymphocytes vary in different clinical states. The object of this study was to characterize the CD8+ lymphocyte subpopulations and CD8+ anti-HIV suppressor activity in HIV-infected and uninfected pregnant and nonpregnant women.
Alan L. Landay +4 more
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The distribution and function of lymphocytes vary in different clinical states. The object of this study was to characterize the CD8+ lymphocyte subpopulations and CD8+ anti-HIV suppressor activity in HIV-infected and uninfected pregnant and nonpregnant women.
Alan L. Landay +4 more
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2004
Publisher Summary The term “effector cell” best describes differentiated T cells with immediate TcR-triggered cytotoxicity or cytokine secretion, as detected in short-term assays, which are currently only feasible in vitro. Investigators agree that antigen recognition by naive CD8+ T cells does not result in either type of effector function (the IL-2
Marta Catalfamo, Pierre A. Henkart
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Publisher Summary The term “effector cell” best describes differentiated T cells with immediate TcR-triggered cytotoxicity or cytokine secretion, as detected in short-term assays, which are currently only feasible in vitro. Investigators agree that antigen recognition by naive CD8+ T cells does not result in either type of effector function (the IL-2
Marta Catalfamo, Pierre A. Henkart
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Nature Reviews Immunology, 2019
A mix of 11 strains of commensal bacteria is shown to specifically induce potent antimicrobial and antitumour IFNγ-producing CD8+ T cells in mice.
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A mix of 11 strains of commensal bacteria is shown to specifically induce potent antimicrobial and antitumour IFNγ-producing CD8+ T cells in mice.
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Seminars in Immunopathology, 2019
CD8+ T cells are important for the protective immunity against intracellular pathogens and tumor. In the case of chronic infection or cancer, CD8+ T cells are exposed to persistent antigen and/or inflammatory signals. This excessive amount of signals often leads CD8+ T cells to gradual deterioration of T cell function, a state called "exhaustion ...
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CD8+ T cells are important for the protective immunity against intracellular pathogens and tumor. In the case of chronic infection or cancer, CD8+ T cells are exposed to persistent antigen and/or inflammatory signals. This excessive amount of signals often leads CD8+ T cells to gradual deterioration of T cell function, a state called "exhaustion ...
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The Journal of Immunology, 2017
Abstract Autoimmune diseases such as type I diabetes (TID) and multiple sclerosis (MS) are chronic conditions that have a significant impact on quality of life. CD8+ T-cells play an important role in the pathogenesis of these diseases. However, drugs that target the entire CD8+ T-cell population are not desirable because this population ...
Linda Wooldridge +19 more
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Abstract Autoimmune diseases such as type I diabetes (TID) and multiple sclerosis (MS) are chronic conditions that have a significant impact on quality of life. CD8+ T-cells play an important role in the pathogenesis of these diseases. However, drugs that target the entire CD8+ T-cell population are not desirable because this population ...
Linda Wooldridge +19 more
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Anti-CD8 conjugated nanoparticles to target mammalian cells expressing CD8
International Journal of Pharmaceutics, 2010This work aimed at the development of targeted drug delivery systems using nanoparticles fused with antibodies. The antibody anti-human CD8 was coupled onto PLGA nanoparticles, and the ability of these particles to specifically target cells expressing CD8 was studied.
M. Margarida Cardoso +3 more
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Inactivation of Misselected CD8 T Cells by CD8 Gene Methylation and Cell Death
Science, 1999Misselected CD8 cells that express T cell receptors (TCRs) that do not recognize class I major histocompatibility complex (MHC) protein can emerge from thymic selection. A postthymic quality control mechanism that purges these cells from the repertoire is defined here.
Harvey Cantor +5 more
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Lack of the CD8+ cell anti-HIV factor in CD8+ cell granules
Blood, 2003AbstractIn HIV infection, CD8+ cells show cytotoxic and noncytotoxic anti-HIV activity. The latter function is mediated, at least in part, by a secreted antiviral protein, the CD8+ cell antiviral factor (CAF). Because antiviral effector molecules, such as perforin and granzymes, reside in the exocytic granules of CD8+ T cells, we examined the ...
Sunil S. Metkar +5 more
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Requirement for CD8 β Chain in Positive Selection of CD8-Lineage T Cells
Science, 1994CD8 is either an αα homodimer or an αβ heterodimer, although most peripheral CD8-lineage T cells express only the CD8αβ heterodimer. The physiological function of CD8β was elucidated with mice that were chimeric for the homozygous disruption of the CD8β gene.
Osami Kanagawa +7 more
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