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The Structure of the CD4 and CD8 Genes
Annual Review of Immunology, 1987The CD4 and CD8 glycoproteins are nonpolymorphic members of the immunoglobulin gene superfamily which are expressed on the surface of functionally distinct populations of T lymphocytes. These molecules, also known respectively as T4/Leu3 and T8/Leu2 in human, and as L3T4 and Lyt2/Lyt3 in mouse, appear to be essential for effective cell-cell inter ...
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American Journal of Respiratory and Critical Care Medicine, 2002
This chapter focuses on CD8 T cells, with an emphasis on the major histocompatibility complex (MHC) Ia-restricted T cells in tuberculosis, and also touches upon the unconventional CD8 T cells restricted by β2m-associated nonclassical MHC Ib or MHC I-like molecules. Although the T cells which recognize mycobacterial glycolipids in the context of group I
JoAnne L. Flynn, Vanja Lazarevic
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This chapter focuses on CD8 T cells, with an emphasis on the major histocompatibility complex (MHC) Ia-restricted T cells in tuberculosis, and also touches upon the unconventional CD8 T cells restricted by β2m-associated nonclassical MHC Ib or MHC I-like molecules. Although the T cells which recognize mycobacterial glycolipids in the context of group I
JoAnne L. Flynn, Vanja Lazarevic
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European Journal of Immunology, 1991
AbstractIn the present study we have examined the possibility that CD4 and CD8 accessory molecules can be passively acquired by thymocytes. We initially observed that most thymocytes contained within the CD4−CD8− subset actually possess low levels of CD4 and CD8 on their cell surface.
Elizabeth W. Shores +2 more
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AbstractIn the present study we have examined the possibility that CD4 and CD8 accessory molecules can be passively acquired by thymocytes. We initially observed that most thymocytes contained within the CD4−CD8− subset actually possess low levels of CD4 and CD8 on their cell surface.
Elizabeth W. Shores +2 more
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Clinical Immunology and Immunopathology, 1992
Increases in plasma levels of soluble CD8 (SCD8) antigen and expansion of the CD8+ CD38+ lymphocyte compartment were early immunologic alterations frequently observed prior to detection of antibodies against human immunodeficiency virus type 1 (HIV-1) and diminution of CD4+ cells in subjects at risk to develop AIDS. These increases identified in the 49
Yagi Mj +7 more
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Increases in plasma levels of soluble CD8 (SCD8) antigen and expansion of the CD8+ CD38+ lymphocyte compartment were early immunologic alterations frequently observed prior to detection of antibodies against human immunodeficiency virus type 1 (HIV-1) and diminution of CD4+ cells in subjects at risk to develop AIDS. These increases identified in the 49
Yagi Mj +7 more
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Role of CD8 homodimers and heterodimers in the activtion of CD8+ T cells
Human Immunology, 1992L.A. Terry +4 more
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The production of cytokines by CD8 T cells is controlled by CD8+ dendritic cells
Immunology Letters, 1997Vadim Kronin +4 more
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