Results 291 to 300 of about 922,724 (383)

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, EarlyView.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

Limited vaccine-induced CD8+ T cell immunity in HIV-infected immunological nonresponders. [PDF]

JCI Insight
Karl V, Graeser A, Kremser A, Bauersfeld L, Emmerich F, Herkt N, Rieg S, Usadel S, Bengsch B, Boettler T, Luxenburger H, Neumann-Haefelin C, Müller MC, Thimme R, Hofmann M.   +14 more
europepmc   +1 more source

The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8+ T cell responses

, 2013
Nada M. Melhem, Kellie N. Smith, Xiao-Li Huang, Bonnie A. Colleton, Weimin Jiang, Robbie B. Mailliard, James I. Mullins, Charles R. Rinaldo   +7 more
openalex   +1 more source

Bifurcate Regulation of Hematopoietic Homeostasis and Bone Osteogenesis by VHL‐HIF2α‐Controlled Adipocyte Function

Advanced Science, EarlyView.
The VHL‐HIF2α (VHL is Von Hippel‐Lindau) axis in adipocytes differentially regulates hematopoiesis and bone formation through stem cell factor (SCF) and chemerin, respectively. This hypoxia‐responsive pathway in adipocytes establishes a systemic signaling network with HSCs and MSCs to maintain tissue homeostasis, revealing a targetable axis for ...
Qian Li, Jia Li, Anshu Tang, Cong Li, Chao Zhang, Congcong Zhang, Yun‐Cai Liu   +6 more
wiley   +1 more source

Sclerosing Angiomatoid Nodular Transformation With Characteristic Imaging Findings: A Report of Three Cases Treated by Laparoscopic Splenectomy. [PDF]

Clin Case Rep
Sawai M, Saito K, Kako T, Kato T, Imafuji H, Shamoto T, Morimoto M, Ogawa R, Takahashi H, Matsuo Y, Mitsui A, Takiguchi S.   +11 more
europepmc   +1 more source

CD8 Negative [PDF]

, 2020
openaire   +1 more source

Epigenetic control of CD8+ T cell differentiation

Nature reviews. Immunology, 2018
A. Henning, R. Roychoudhuri, N. Restifo
semanticscholar   +1 more source

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source

Decoding the distinct immune landscape and possible regulatory mechanisms of autoimmune hepatitis through integrated single-cell and bulk RNA sequencing. [PDF]

PLoS One
Chi G, Che Y, Pei J, Li X, Wang J.
europepmc   +1 more source