Results 61 to 70 of about 883,722 (384)

Imaging the Effector CD8 Synapse [PDF]

, 2017
Here, we describe 4D imaging of effector CD8+ T cells as they conjugate and kill live targets in vitro and analyze the polarization dynamics of intracellular compartments to this cell-cell interface.
Frazer, Gordon L, Asano, Yukako, Griffiths, Gillian M   +2 more
openaire   +2 more sources

Defining Memory CD8 T Cell [PDF]

Frontiers in Immunology, 2018
CD8 T cells comprising the memory pool display considerable heterogeneity, with individual cells differing in phenotype and function. This review will focus on our current understanding of heterogeneity within the antigen-specific memory CD8 T cell compartment and classifications of memory CD8 T cell subsets with defined and discrete functionalities ...
Matthew D. Martin, Vladimir P. Badovinac, Vladimir P. Badovinac, Vladimir P. Badovinac   +3 more
openaire   +3 more sources

Sustained Id2 regulation of E proteins is required for terminal differentiation of effector CD8+ T cells. [PDF]

, 2018
CD8+ T cells responding to infection differentiate into a heterogeneous population composed of progeny that are short-lived and participate in the immediate, acute response and those that provide long-lasting host protection.
Goldrath, Ananda W, Milner, J Justin, Nadjsombati, Marija S, Omilusik, Kyla D, Shaw, Laura A, Yu, Bingfei   +5 more
core   +1 more source

Peripheral Tolerance of CD8 T Lymphocytes [PDF]

Immunity, 2005
Whereas high-avidity recognition of peptide-MHC complexes by developing T cells in the thymus results in deletion and promotes self-tolerance, such recognition by mature T cells in the periphery results in activation and clonal expansion. This dichotomy represents the basis of a dilemma that has stumped immunologists for many years, how are self ...
Linda A. Sherman, William L. Redmond
openaire   +3 more sources

CD8⁺ T‐cell specificity is compromised at a defined MHCI/CD8 affinity threshold [PDF]

Immunology & Cell Biology, 2016
The CD8 co‐receptor engages peptide‐major histocompatibility complex class I (pMHCI) molecules at a largely invariant site distinct from the T‐cell receptor (TCR)‐binding platform and enhances the sensitivity of antigen‐driven activation to promote effective CD8+ T‐cell immunity. A small increase in the strength of the pMHCI/CD8 interaction (~1.5‐fold)
Stephen Man, Sian Llewellyn-Lacey, John S. Bridgeman, Mick Bailey, James E. McLaren, Tamsin Dockree, Mathew Clement, Christopher J. Holland, Hugo A. van den Berg, David Price, David Price, Linda Wooldridge, Kristin Ladell, Kelly L. Miners, Scott R. Burrows, Emma Gostick   +15 more
openaire   +6 more sources

Higher Expression of Activated CD8+ T Lymphocytes (CD8+CD25+, CD8+CD69+ and CD8+CD95+) Mediate Early Post-Transplant Acute Tubular Injury in Kidney Recipients

Frontiers in Bioscience-Landmark, 2023
Background: Acute kidney injury (AKI) is a leading cause of early post-transplant kidney damage. Furthermore, acute tubular necrosis (ATN) is appointed as the most prevalent form of AKI, a frequent multifactorial process associated with high morbidity and mortality, yet giving rise to delayed graft function (DGF) and, ultimately, allograft dysfunction.
Manuel Muro, Santiago Llorente, Alfredo Minguela, Jesús de la Peña-Moral, Maria R. Moya-Quiles, Rafael Alfaro, Isabel Legaz, Víctor Jimenez-Coll, Francisco Boix   +8 more
openaire   +4 more sources

Distribution of melanocytes in the skin of psoriasis patients

Vestnik Dermatologii i Venerologii, 2019
Psoriasis is a chronic immune-mediated inflammatory disease with predominant damage to the skin and joints. Despite fundamental studies of its pathogenesis, the cause of the development of the T-cell response has not been determined. More recently, a new
A. S. Zhukov, V. R. Khairutdinov, I. E. Belousova, A. V. Samtsov   +3 more
doaj   +1 more source

TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance A recent exciting development in cancer therapy involves using a patient’s own immune system to attack cancers. The attack is carried out by CD8+ T cells that destroy the malignant cells; after infiltrating tumors, however, these cells ...
Hyungseok Seo, Joyce Chen, Edahí González-Avalos, Daniela Samaniego-Castruita, Arundhoti Das, Yueqiang H. Wang, Isaac F. López-Moyado, Romain O. Georges, Wade Zhang, A. Onodera, Cheng-Jang Wu, Li-Fan Lu, P. Hogan, A. Bhandoola, A. Rao   +14 more
semanticscholar   +1 more source

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

The Evolving Role of CD8+CD28- Immunosenescent T Cells in Cancer Immunology [PDF]

, 2019
Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune response to cancer. Thus, induction of their activity is the ultimate aim of all immunotherapies.
Dey, Mahua, Fetcko, Kaleigh, Henriquez, Mario, Huff, Wei X., Kwon, Jae Hyun   +4 more
core   +1 more source