Results 71 to 80 of about 883,722 (384)

Neoadjuvant sipuleucel-T induces both Th1 activation and immune regulation in localized prostate cancer

OncoImmunology, 2019
Sipuleucel-T is the only FDA-approved immunotherapy for metastatic castration-resistant prostate cancer. The mechanism by which this treatment improves survival is not fully understood.
Katsunobu Hagihara, Stephen Chan, Li Zhang, David Y. Oh, Xiao X. Wei, Jeffry Simko, Lawrence Fong   +6 more
doaj   +1 more source

Immunohistochemical analysis of metastasising hepatocellular carcinomas in dogs

Veterinární Medicína, 2016
In this study, the immunohistochemical features of primary hepatocellular carcinomas and their metastases in visceral organs, including the lungs, spleen and kidneys were examined using antibodies against carcino-embryonic antigen (CEA) cytokeratin (CK ...
R. Ciaputa, P. Bandoch, K. Lewandowska, J.A. Madej, M. Kandefer-Gola, I. Janus, M. Nowak   +6 more
doaj   +1 more source

HTLV-1 Proliferation after CD8+ Cell Depletion by Monoclonal Anti-CD8 Antibody Administration in Latently HTLV-1-Infected Cynomolgus Macaques

Microbiology Spectrum, 2023
Human T-cell leukemia virus type 1 (HTLV-1) induces chronic asymptomatic latent infection with a substantial proviral load but without significant viral replication in vivo.
Midori Nakamura-Hoshi, Takushi Nomura, Masako Nishizawa, Trang Thi Thu Hau, Hiroyuki Yamamoto, Midori Okazaki, Hiroshi Ishii, Kenzo Yonemitsu, Yuriko Suzaki, Yasushi Ami, Tetsuro Matano   +10 more
doaj   +1 more source

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small cell lung cancer treated with PD-1 blockade

Nature Network Boston, 2018
Evidence from mouse chronic viral infection models suggests that CD8+ T cell subsets characterized by distinct expression levels of the receptor PD-1 diverge in their state of exhaustion and potential for reinvigoration by PD-1 blockade.
D. Thommen, V. Koelzer, P. Herzig, A. Roller, Marcel P. Trefny, S. Dimeloe, A. Kiialainen, Jonathan Hanhart, Catherine Schill, C. Hess, S. Savic Prince, M. Wiese, D. Lardinois, Ping-Chih Ho, C. Klein, V. Karanikas, K. Mertz, T. Schumacher, A. Zippelius   +18 more
semanticscholar   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes [PDF]

, 1990
Although the relative contribution of different immune effector functions to clearing tissues of cytomegalovirus is controversial, the contribution of CD8+ T lymphocytes has generally been accepted as essential. In this report, we show that under certain
Jonjic, Stipan, Koszinowski, Ulrich H., Lucin, Pero, Pavic, Ivica, Rukavina, Daniel   +4 more
core  

IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages.

, 2002
CD4+ T cells are crucial to the development of CD8+ T cell responses against hepatocytes infected with malaria parasites. In the absence of CD4+ T cells, CD8+ T cells initiate a seemingly normal differentiation and proliferation during the first few days
A Franco, AB Lyons, Alexandre Morrot, C Kurts, DP Dialynas, F Ossendorp, F Zavala, Fidel Zavala, G Sano, Gen-ichiro Sano, H Bodmer, J Ohara, JA Keene, JA Pedras-Vasconcelos, JD Altman, JM McCune, JM Riberdy, JP Ridge, Julius C.R. Hafalla, KS Schluns, L Peng, LH Carvalho, LR Huang, Luzia H. Carvalho, Maria A. Curotto de Lafaille, MH Kaplan, MM Rodrigues, P Borrow, P Romero, RA Tripp, RD Cardin, RJ Armitage, RM Buller, RP Bucy, SO Andreasen, SP Schoenberger, SR Bennett, T Ohteki, T Schuler, W Allan, WE Paul, WE Seaman, WR Weiss, Y Miyahira, Z Lu   +44 more
core   +1 more source

Research progress on targetingmetabolic reprogramming of tumormicroenvironment to reinvigorate exhausted CD8+T cells

生物医学转化, 2022
CD8+T cell exhaustion is one of the most important reasons for the low response rate of immunotherapy. In the tumor microenvironment(TME), tumor cells preferentially utilize metabolic reprogramming such as aerobic glycolysis to get an advantage on ...
Zhong Jiaxin, Lin Xiaorong, Hu Hai
doaj   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection. [PDF]

, 2016
HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors that eventually result in T cell exhaustion and failure to control viral replication.
Abdel-Mohsen, Mohamed, Burwitz, Benjamin J, Chew, Glen M, Clayton, Kiera L, Deeks, Steven G, Fujita, Tsuyoshi, Hammond, Katherine B, Hansen, Scott G, Hecht, Frederick M, Ishii, Naoto, Korman, Alan J, Liegler, Teri, Maurer, Mark, Mitchell, Brooks I, Ndhlovu, Lishomwa C, Ostrowski, Mario, Reed, Jason S, Sacha, Jonah B, Shikuma, Cecilia M, Webb, Gabriela M, Wu, Helen L   +20 more
core   +3 more sources