Results 221 to 230 of about 500,097 (256)

Single‐Nucleus Transcriptomic Atlas of Human Vellus Hair Pilosebaceous Units Reveals Age‐Associated Remodeling

Advanced Science, EarlyView.
Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li, Zhuoqiong Qiu, Xiaoyu Pan, Geyang Xu, Shanshan Peng, Ronghui Zhu, Qiuyang Luo, Xiaokai Fang, Xu Yao, Wei Li   +9 more
wiley   +1 more source

Targeting Macrophage‐Mediated Lymphatic Immunosuppression to Prevent Tumor Recurrence After Microwave Ablation

Advanced Science, EarlyView.
Incomplete microwave ablation induces animmunosuppressive microenvironment in tumor‐draining lymph nodes. An albumin‐based lipoprotein nanosystem enables coordinated delivery of immunomodulators to tumor‐draining lymph nodes and residual tumors, reverses post‐ablation immunosuppression, suppresses residual tumor growth, and promotes durable antitumor ...
Xuexia Shan, Yuting Shen, Xiaodong Hou, Fengshan Jin, Shaoyue Li, Weichen Xu, Weiwei Ren, Xiaowan Bo, Qiuyan Li, Shuo Liu, Weifan Hao, Chengzhong Peng, Huixiong Xu, Liping Sun, Wenwen Yue   +14 more
wiley   +1 more source

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source

Epstein-Barr Virus and Multiple Sclerosis: Mechanistic Insights into Virus-Driven Autoimmunity. [PDF]

Microorganisms
Bashiardes S, Krashias G, Englezou E, Lambrianides A, Pitsas G, Pantzaris M, Richter J.   +6 more
europepmc   +1 more source

T cells in type 1 diabetes: mechanisms of β-cell autoimmunity, innate-adaptive immune crosstalk, and translational immunotherapy. [PDF]

Front Immunol
Amer B, Alnukhali M, Haidarah A, Ahmad A.   +3 more
europepmc   +1 more source

Mucosal immunity: mechanism and application in cancer immunotherapy. [PDF]

J Hematol Oncol
Xu M, Xia R, Wei Y, Peng X, Wei X.
europepmc   +1 more source

Antitumor immunity and immune-related toxicity during immune checkpoint inhibition: mechanistic overlap, tissue selectivity, and interventional evidence. [PDF]

Front Immunol
Shi C, Li C, Yan J.
europepmc   +1 more source

Improving peptide vaccine manufacturability without sacrificing immunogenicity: substitution of methionine and cysteine with oxidation-resistant isosteres. [PDF]

J Immunol
Ishizuka AS, Garliss CM, Goddu RN, Merolle M, Schrager A, Ramirez-Valdez A, Ren Q, Baharom F, Essandoh M, Palacorolla NG, Finnigan JP, Douek DC, Bhardwaj N, Seder RA, Lynn GM, Wilson DR.   +15 more
europepmc   +1 more source