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Understanding immune checkpoint inhibitor efficacy through spatial decoding of the lung cancer tumor immune microenvironment. [PDF]
J Clin InvestZou T, Minna JD.
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Immunological Biomarkers in Glioblastoma: Targeting T and NK Cells for Enhanced Diagnosis and Prognosis. [PDF]
BiologicsAkbari AM +6 more
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Channeling antigens to CD8 + T cells
Science, 2023Perforin-2 facilitates antigen translocation to the cytosol in cross-presenting dendritic ...
Kavita, Rawat, Claudia V, Jakubzick
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Antigen‐presenting Cells for CD8+ T Cells
Immunological Reviews, 1990Evidence is presented that a wide variety of cell types are capable of presenting class I alloantigens to purified unprimed CD8+ cells in the absence of added help. These cells include dendritic cells, a population of Ia- Thy 1- cells in spleen, peritoneal exudate cells and one of three T-tumor lines. Some cell types, e.g.
J, Sprent, M, Schaefer
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CD8 and antigen-specific T cell adhesion cascades
Seminars in Immunology, 1993Activation of T cells involves both the antigen-specific T cell receptor and a number of additional accessory receptors. For cytotoxic T lymphocytes these include CD8, LFA-1 and VLA receptors. Recent studies have demonstrated that these receptors become activated to mediate adhesion upon crosslinking of the T cell receptor, and can deliver co ...
A M, O'Rourke +2 more
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Clinical Immunology and Immunopathology, 1992
Increases in plasma levels of soluble CD8 (SCD8) antigen and expansion of the CD8+ CD38+ lymphocyte compartment were early immunologic alterations frequently observed prior to detection of antibodies against human immunodeficiency virus type 1 (HIV-1) and diminution of CD4+ cells in subjects at risk to develop AIDS. These increases identified in the 49
M J, Yagi +7 more
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Increases in plasma levels of soluble CD8 (SCD8) antigen and expansion of the CD8+ CD38+ lymphocyte compartment were early immunologic alterations frequently observed prior to detection of antibodies against human immunodeficiency virus type 1 (HIV-1) and diminution of CD4+ cells in subjects at risk to develop AIDS. These increases identified in the 49
M J, Yagi +7 more
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Decreased production of CD8 (T8) antigen after immunotherapy
Journal of Clinical Immunology, 1989The working mechanism(s) of immunotherapy still remains ill defined. As T cells bearing CD8 antigen possess suppressor/cytotoxic function, this study was conducted to examine the effect of immunotherapy on the production of CD8 antigen. Peripheral blood mononuclear cells (MNC) were obtained from 21 newly diagnosed and 23 hyposensitized (greater than 1 ...
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