Results 231 to 240 of about 257,746 (309)

B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the antiviral CD8⁺ T-cell response. [PDF]

Cell Mol Immunol
Liu X, Demircik F, Antipova M, Stylianakis E, Klein M, Bejarano D, Elwy A, Ebering A, Blanfeld M, Carter K, Johann L, Uhlfelder DC, Blickberndt E, Chen Y, Probst HC, Hövelmeyer N, Bopp T, Arens R, Bunse L, den Haan JMM, Gommerman JL, von Stebut E, Clausen BE, Schlitzer A, Lang KS, Su B, Backer RA, Lemmermann NA, Waisman A.   +28 more
europepmc   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

How the Immune System Recognizes the Myriad of Antigens: Diversity of MHC (HLA) and TCR Molecules. [PDF]

Juntendo Med J
Akiba H.
europepmc   +1 more source

Living Hydrogels: Harnessing Microorganism–Material Synergy for Next‐Generation Therapeutics

Advanced Science, EarlyView.
 . ABSTRACT Microorganism‐based therapies, particularly those utilizing probiotics, have emerged as a powerful biomedical strategy owing to their inherent living functionalities. These living systems can dynamically interact with host environments and self‐regulate their activity, offering superior adaptability, prolonged functionality, and ...
Shuifang Mao, Bingyao Bai, Xingqian Ye, Yiliang Lin   +3 more
wiley   +1 more source

Neutrophil Antigen Presentation Reprograms the Tumor Microenvironment and Elicits Durable and Broad Antitumor Immunity. [PDF]

Cancer Res Commun
Wang H, Meng Q, Ito Y, Kusumakar K, Mayadas T.   +4 more
europepmc   +1 more source

Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai, Lingyou Sun, Luping Zhang, Jianguo Sun   +12 more
wiley   +1 more source

Cold atmospheric plasma-engineered nanovaccine with spatiotemporal sequential immunization reprograms antitumor immunity. [PDF]

Sci Adv
Li S, Wang P, Wu Z, Mu Q, Zhou R, Liu N, Xi Y, An X, Li Y, Sun D, Liang H, Zhang C, Huang Q, Zhuang Z, Wang X, Zhao L, Gan D, Wang X, Liu X, Liu G, Liu C.   +20 more
europepmc   +1 more source

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

Trogocytosis and Allergy. [PDF]

Cells
Boeva OS, Abbasova VS, Kozlov VA, Pashkina EA.   +3 more
europepmc   +1 more source