Results 231 to 240 of about 174,472 (265)

Molecular Analysis of the Interaction of p56lck with the CD4 and CD8 Antigens

1991
The CD4 and CD8 antigens on the surface of T cells appear to bind to major histocompatibility complex (MHC) class II and I antigens, respectively. These antigens also synergize with the Ti(TcR)/CD3 complex in the potentiation of T-cell proliferation. Our earlier work demonstrated that the CD4 and CD8 receptors are coupled to a protein-tyrosine kinase ...
C E, Rudd, E K, Barber, K E, Burgess, J Y, Hahn, A D, Odysseos, M S, Sy, S F, Schlossman   +6 more
openaire   +2 more sources

CD8+ T cell tolerance following antigen recognition on hepatocytes

Journal of Autoimmunity, 2010
Hepatocytes, the predominant cell type in the liver, are the main cell infected by the hepatitis C virus (HCV) and represent important targets for immune therapy. Although early studies suggested that this parenchymal cell expresses low levels of class I MHC molecules, hepatocytes are emerging as important players in intrahepatic immune responses.
Lauren E, Holz, Alessandra, Warren, David G, Le Couteur, David G, Bowen, Patrick, Bertolino   +4 more
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Specificity of proliferative response of human CD8 clones to mycobacterial antigens

European Journal of Immunology, 1988
AbstractHuman CD8 T lymphocyte clones (TLC) were generated from the pleural effusion of patients with tuberculosis using a protocol that required, in addition to antigen, co‐culture of purifed CD8+ T cells, accessory cells, interleukin 2 (IL2) and anti‐CD3‐Sepharose. The TLC obtained were stimulated by mycobacterial soluble extracts in an IL2‐dependent
A, Rees, A, Scoging, A, Mehlert, D B, Young, J, Ivanyi   +4 more
openaire   +2 more sources

Antigen presentation to CD8+ T cells:cross-priming in infectious diseases

Current opinion in immunology, 2001
Recent studies indicate that, in most types of infections, antigen presentation by 'professional' bone-marrow-derived cells is essential for priming pathogen-specific CD8+ T cells. This is true even in the absence of direct infection of these cells, which indicates that cross-priming is an essential component of the immune response against pathogens.
den Haan, J M, Bevan, M J
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Soluble CD8 antigen in systemic sclerosis.

Journal of clinical & laboratory immunology, 1990
In 15 patients suffering from systemic sclerosis (PSS) the function of CD8+ circulating lymphocytes was assayed by determining soluble CD8 antigen (sCD8) both in sera and in 48 hr PHA-conditioned media of peripheral blood mononuclear cells (PBMCs). Furthermore, the frequency of circulating activated CD8+ cells, which express DR antigens, interleukin-2 ...
Famularo G, GIACOMELLI, Roberto, Sacchetti S, Danese C, Luciani AM, Perego MA, Tonietti G.   +6 more
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Accumulation of CD8⁺ Cells after Immunization with Soluble Antigen

Scandinavian Journal of Immunology, 1990
Rats were immunized with ovalbumin, either subculaneously or by aerosol inhalation. The lymphocyte distribution in lymph nodes, peripheral blood, and spleen was investigated by flow cytometry after labelling with T pan (0X19 and W3/13), T helper lymphocytes (W3/25), T cytotoxic/suppressor lymphocytes (OX8), k light chain (MAR 18‐5), or MHC class II ...
G, Nilsson, P, Matsson, S, Ahlstedt
openaire   +2 more sources

Antigen-independent and antigen-dependent methods to numerically expand CD19-specific CD8+ T cells

Experimental Hematology, 2007
Preclinical and clinical trials are investigating the potential of T cells genetically modified to express a first-generation CD19-specific chimeric antigen receptor (CAR), designated CD19R, for adoptive immunotherapy of B-lineage leukemias and lymphomas.
Tontanai, Numbenjapon, Lisa M, Serrano, Wen-Chung, Chang, Stephen J, Forman, Michael C, Jensen, Laurence J N, Cooper   +5 more
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Assessing antigen-specific CD8+ CTL responses in humans.

Methods in molecular medicine, 2002
Townsend and colleagues (1) were the first to demonstrate, in 1984, that target cells that had been transfected with single viral RNA segments could be specifically recognized by cytotoxic T lymphocytes (CTL). Recombinant vaccinia viruses that expressed single-gene products were subsequently used to identify major target antigens for CTL (2,3).
openaire   +3 more sources

Mechanisms Underlying Antigen-Specific CD8+ T Cell Homeostasis

Science, 2001
Badovinac et al . ([1][1]) reported important new insights concerning the role of perforin and interferon-γ (IFN-γ) in regulating antigen-specific (Ag-specific) CD8+ T cell homeostasis. Using an attenuated strain of Listeria monocytogenes , they demonstrated that absence of perforin resulted ...
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Soluble CD8 Antigen in Plasmodium falciparum Malaria

Journal of Infectious Diseases, 1989
P G, Kremsner, U, Bienzle
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