Results 261 to 270 of about 459,921 (305)

Channeling antigens to CD8 ⁺ T cells

Science, 2023
Perforin-2 facilitates antigen translocation to the cytosol in cross-presenting dendritic ...
Kavita, Rawat, Claudia V, Jakubzick
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Antigen‐presenting Cells for CD8+ T Cells

Immunological Reviews, 1990
Evidence is presented that a wide variety of cell types are capable of presenting class I alloantigens to purified unprimed CD8+ cells in the absence of added help. These cells include dendritic cells, a population of Ia- Thy 1- cells in spleen, peritoneal exudate cells and one of three T-tumor lines. Some cell types, e.g.
J, Sprent, M, Schaefer
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CD8 and antigen-specific T cell adhesion cascades

Seminars in Immunology, 1993
Activation of T cells involves both the antigen-specific T cell receptor and a number of additional accessory receptors. For cytotoxic T lymphocytes these include CD8, LFA-1 and VLA receptors. Recent studies have demonstrated that these receptors become activated to mediate adhesion upon crosslinking of the T cell receptor, and can deliver co ...
A M, O'Rourke, B, Ybarrondo, M F, Mescher   +2 more
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Increases in soluble CD8 antigen in plasma, and CD8+ and CD8+CD38+ cells in human immunodeficiency virus type-1 infection

Clinical Immunology and Immunopathology, 1992
Increases in plasma levels of soluble CD8 (SCD8) antigen and expansion of the CD8+ CD38+ lymphocyte compartment were early immunologic alterations frequently observed prior to detection of antibodies against human immunodeficiency virus type 1 (HIV-1) and diminution of CD4+ cells in subjects at risk to develop AIDS. These increases identified in the 49
M J, Yagi, F N, Chu, J D, Jiang, J, Wallace, P, Mason, Y, Liu, J, Carafa, J G, Bekesi   +7 more
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Decreased production of CD8 (T8) antigen after immunotherapy

Journal of Clinical Immunology, 1989
The working mechanism(s) of immunotherapy still remains ill defined. As T cells bearing CD8 antigen possess suppressor/cytotoxic function, this study was conducted to examine the effect of immunotherapy on the production of CD8 antigen. Peripheral blood mononuclear cells (MNC) were obtained from 21 newly diagnosed and 23 hyposensitized (greater than 1 ...
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Molecular Analysis of the Interaction of p56lck with the CD4 and CD8 Antigens

1991
The CD4 and CD8 antigens on the surface of T cells appear to bind to major histocompatibility complex (MHC) class II and I antigens, respectively. These antigens also synergize with the Ti(TcR)/CD3 complex in the potentiation of T-cell proliferation. Our earlier work demonstrated that the CD4 and CD8 receptors are coupled to a protein-tyrosine kinase ...
C E, Rudd, E K, Barber, K E, Burgess, J Y, Hahn, A D, Odysseos, M S, Sy, S F, Schlossman   +6 more
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CD8+ T cell tolerance following antigen recognition on hepatocytes

Journal of Autoimmunity, 2010
Hepatocytes, the predominant cell type in the liver, are the main cell infected by the hepatitis C virus (HCV) and represent important targets for immune therapy. Although early studies suggested that this parenchymal cell expresses low levels of class I MHC molecules, hepatocytes are emerging as important players in intrahepatic immune responses.
Lauren E, Holz, Alessandra, Warren, David G, Le Couteur, David G, Bowen, Patrick, Bertolino   +4 more
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