Results 271 to 280 of about 459,921 (305)
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Antigen presentation to CD8+ T cells:cross-priming in infectious diseases
Current opinion in immunology, 2001Recent studies indicate that, in most types of infections, antigen presentation by 'professional' bone-marrow-derived cells is essential for priming pathogen-specific CD8+ T cells. This is true even in the absence of direct infection of these cells, which indicates that cross-priming is an essential component of the immune response against pathogens.
den Haan, J M, Bevan, M J
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Specificity of proliferative response of human CD8 clones to mycobacterial antigens
European Journal of Immunology, 1988AbstractHuman CD8 T lymphocyte clones (TLC) were generated from the pleural effusion of patients with tuberculosis using a protocol that required, in addition to antigen, co‐culture of purifed CD8+ T cells, accessory cells, interleukin 2 (IL2) and anti‐CD3‐Sepharose. The TLC obtained were stimulated by mycobacterial soluble extracts in an IL2‐dependent
A, Rees +4 more
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Soluble CD8 antigen in systemic sclerosis.
Journal of clinical & laboratory immunology, 1990In 15 patients suffering from systemic sclerosis (PSS) the function of CD8+ circulating lymphocytes was assayed by determining soluble CD8 antigen (sCD8) both in sera and in 48 hr PHA-conditioned media of peripheral blood mononuclear cells (PBMCs). Furthermore, the frequency of circulating activated CD8+ cells, which express DR antigens, interleukin-2 ...
Famularo G +6 more
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Accumulation of CD8+ Cells after Immunization with Soluble Antigen
Scandinavian Journal of Immunology, 1990Rats were immunized with ovalbumin, either subculaneously or by aerosol inhalation. The lymphocyte distribution in lymph nodes, peripheral blood, and spleen was investigated by flow cytometry after labelling with T pan (0X19 and W3/13), T helper lymphocytes (W3/25), T cytotoxic/suppressor lymphocytes (OX8), k light chain (MAR 18‐5), or MHC class II ...
G, Nilsson, P, Matsson, S, Ahlstedt
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Assessing antigen-specific CD8+ CTL responses in humans.
Methods in molecular medicine, 2002Townsend and colleagues (1) were the first to demonstrate, in 1984, that target cells that had been transfected with single viral RNA segments could be specifically recognized by cytotoxic T lymphocytes (CTL). Recombinant vaccinia viruses that expressed single-gene products were subsequently used to identify major target antigens for CTL (2,3).
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Soluble CD8 Antigen in Plasmodium falciparum Malaria
Journal of Infectious Diseases, 1989P G, Kremsner, U, Bienzle
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Mechanisms Underlying Antigen-Specific CD8+ T Cell Homeostasis
Science, 2001Badovinac et al . ([1][1]) reported important new insights concerning the role of perforin and interferon-γ (IFN-γ) in regulating antigen-specific (Ag-specific) CD8+ T cell homeostasis. Using an attenuated strain of Listeria monocytogenes , they demonstrated that absence of perforin resulted ...
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The Expansion and Maintenance of Antigen‐Selected CD8+ T Cell Clones
2007The biological purpose of the mature, postthymic CD8(+) T cell is to respond to microbial antigens with a developmental program of clonal expansion and concomitant differentiation leading to effector cells (T(EFF)) that provide antimicrobial defense. Because many microbial infections persist into a chronic phase, this antigen-stimulated developmental ...
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Cancer germline antigens and tumor-agnostic CD8+ T cell evasion
Trends in Immunology, 2022Reno Debets +2 more
exaly
B-chronic lymphocytic leukemia with aberrant expression of CD8 antigen
2001SUMMARY - OBJECTIVE: The aim of this study was to describe an unusual phenotype in otherwise typical B-chronic lymphocytic leukemia (B-CLL) and confirm its belonging to the neoplastic cell clone. PATIENTS AND METHODS: Peripheral blood (PB) samples of 140 patients (91F/49 M, median age 61.0 years) with B-CLL were analysed by flow
Kardum, Mirjana-Marijana +5 more
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