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Antigen cross-presentation potentiating cancer vaccine adjuvant for T cell expansion and synergy with anti-PD-1. [PDF]
NPJ VaccinesDang GC +5 more
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Differentiation and activation antigens on CD8 T cells
, 2016 Mongkolsapaya, J +2 more
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Channeling antigens to CD8 + T cells
Science, 2023Perforin-2 facilitates antigen translocation to the cytosol in cross-presenting dendritic ...
Kavita, Rawat, Claudia V, Jakubzick
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Antigen‐presenting Cells for CD8+ T Cells
Immunological Reviews, 1990Evidence is presented that a wide variety of cell types are capable of presenting class I alloantigens to purified unprimed CD8+ cells in the absence of added help. These cells include dendritic cells, a population of Ia- Thy 1- cells in spleen, peritoneal exudate cells and one of three T-tumor lines. Some cell types, e.g.
J, Sprent, M, Schaefer
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CD8 and antigen-specific T cell adhesion cascades
Seminars in Immunology, 1993Activation of T cells involves both the antigen-specific T cell receptor and a number of additional accessory receptors. For cytotoxic T lymphocytes these include CD8, LFA-1 and VLA receptors. Recent studies have demonstrated that these receptors become activated to mediate adhesion upon crosslinking of the T cell receptor, and can deliver co ...
A M, O'Rourke +2 more
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CD8+ T cell tolerance following antigen recognition on hepatocytes
Journal of Autoimmunity, 2010Hepatocytes, the predominant cell type in the liver, are the main cell infected by the hepatitis C virus (HCV) and represent important targets for immune therapy. Although early studies suggested that this parenchymal cell expresses low levels of class I MHC molecules, hepatocytes are emerging as important players in intrahepatic immune responses.
Lauren E, Holz +4 more
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Decreased production of CD8 (T8) antigen after immunotherapy
Journal of Clinical Immunology, 1989The working mechanism(s) of immunotherapy still remains ill defined. As T cells bearing CD8 antigen possess suppressor/cytotoxic function, this study was conducted to examine the effect of immunotherapy on the production of CD8 antigen. Peripheral blood mononuclear cells (MNC) were obtained from 21 newly diagnosed and 23 hyposensitized (greater than 1 ...
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Mechanisms Underlying Antigen-Specific CD8+ T Cell Homeostasis
Science, 2001Badovinac et al . ([1][1]) reported important new insights concerning the role of perforin and interferon-γ (IFN-γ) in regulating antigen-specific (Ag-specific) CD8+ T cell homeostasis. Using an attenuated strain of Listeria monocytogenes , they demonstrated that absence of perforin resulted ...
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Antigen presentation to CD8+ T cells
Current opinion in immunology, 2001Recent studies indicate that, in most types of infections, antigen presentation by 'professional' bone-marrow-derived cells is essential for priming pathogen-specific CD8+ T cells. This is true even in the absence of direct infection of these cells, which indicates that cross-priming is an essential component of the immune response against pathogens.
den Haan, J M, Bevan, M J
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