Results 231 to 240 of about 471,511 (315)

Acute COVID-19 is associated with altered CD8 T-cells indicative of impaired ability to control Epstein-Barr virus reactivation. [PDF]

Med Microbiol Immunol
Stervbo U, Anft M, Paniskaki K, Blazquez-Navarro A, Doevelaar A, Skrzypczyk S, Kohut E, Kurek J, Wehler P, Kaliszczyk S, Rosiewicz K, Seibert FS, Hölzer B, Thieme CJ, Roch T, Konik MJ, Berger MM, Brenner T, Kölsch U, Adamzik M, Schmueck-Henneresse M, Scheibenbogen C, Dolff S, Dittmer U, Witzke O, Westhoff TH, Babel N.   +26 more
europepmc   +1 more source

Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction

Advanced Science, EarlyView.
This study presents the Tech‐tetrahedron, a designer dynamic DNA nanoaggregate engineered for precise mitochondrial energy restriction. Its trinity‐functionalized design integrates navigable unit, telomerase‐activated latch, and self‐assembly module.
Ruijia Deng, Jing Sheng, Ben Niu, Wenjuan Fu, Yingjie Yang, Zuowei Xie, Shuang Xie, Yunxuan He, Meilin Gong, Jue Wang, Yan Pi, Ming Chen, Kai Chang   +12 more
wiley   +1 more source

Correction: <i>Piscirickettsia salmonis</i> elicited an antigen-specific cytotoxic response dependent on CD8+ T cells in Atlantic salmon. [PDF]

Front Immunol
Barraza-Rojas F, Wong-Benito V, Valdés-Henriquez D, Maisey K, Dixon B, Imarai M.   +5 more
europepmc   +1 more source

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, EarlyView.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source

PD-1 and TIGIT coexpression enables selective enrichment of clonally expanded tumor-reactive CD8 T cells for melanoma TIL therapy. [PDF]

J Transl Med
Ducoin K, Beauvais T, Goward J, Ahondo M, Lambot S, Mordelet A, Daminette A, Thabot M, Deng J, Tian S, Rulli S, Quereux G, Khammari A, Labarrière N.   +13 more
europepmc   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Cytolysis limits IFN-I and effector memory CD8 T cells after viral vector vaccination. [PDF]

Mol Ther Nucleic Acids
Penaloza-MacMaster P.
europepmc   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source

Author Correction: Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells. [PDF]

Nat Immunol
Sinclair LV, Youdale T, Spinelli L, Gakovic M, Langlands AJ, Pathak S, Howden AJM, Ganley IG, Cantrell DA.   +8 more
europepmc   +1 more source