Results 241 to 250 of about 471,511 (315)

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source

Single-Cell Transcriptomics Reveals the Potential Role of GZMK+ CD8+ T Cells in Cell Senescence of Triple-Negative Breast Cancer. [PDF]

Int J Genomics
Zhou D, Hu T, Xu B, Zhu J, Ma M, Zhang W, Xie L, Ouyang Z, Xu Y, Su Y.   +9 more
europepmc   +1 more source

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

Advanced Science, EarlyView.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang, Tingbo Liang, Qida Hu   +11 more
wiley   +1 more source

Mitochondrial complex II orchestrates divergent effects in CD4+ and CD8+ T cells. [PDF]

J Clin Invest
Seike K, Chu SA, Sumii Y, Ikeda T, Wu MC, Maneix L, Zhao D, Sun Y, Cieslik M, Reddy P.   +9 more
europepmc   +1 more source

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

<i>Piscirickettsia salmonis</i> elicited an antigen-specific cytotoxic response dependent on CD8+ T cells in Atlantic salmon. [PDF]

Front Immunol
Barraza-Rojas F, Wong-Benito V, Valdés-Henriquez D, Maisey K, Dixon B, Imarai M.   +5 more
europepmc   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

IL-21 enhances the cytotoxicity of intratumoral CD8+ T cells, improving radiation efficacy. [PDF]

JCI Insight
Li XY, Xie XQ, Wei BC, Sun XZ, Chen MX, Liu RF, Tao QX, Huang YH, Wang Q, Ma SS, Wei L, Xiao R, Liu ZY, Yu JM, Wu M, Chen D.   +15 more
europepmc   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Peripheral vaccination-induced brain-resident memory CD8+ T cells durably protect mice against intracranial malignancy. [PDF]

J Clin Invest
Mix MR, Sievers CM, Hassert M, Kannan SK, Pewe LL, Huang SC, He R, Fain CE, Heidarian M, Hancox LS, Arumugam SA, Beltz TG, Jin F, Johnson AJ, Carter CS, Butler NS, Salem AK, Badovinac VP, Harty JT.   +18 more
europepmc   +1 more source