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Irradiation-induced pneumonitis relies on the CD95/ CD95-L system
, 2006 Heinzelmann, F +9 more
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CD95 tyrosine phosphorylation is required for CD95 oligomerization
Apoptosis, 2006Proapoptotic stimuli, such as CD95 ligand and hydrophobic bile acids induce an epidermal growth factor receptor (EGFR)-catalyzed tyrosine phosphorylation of CD95-death receptor in hepatocytes, as a prerequisite for CD95-translocation to the plasma membrane, formation of the death-inducing signalling complex and execution of apoptotic cell death ...
Andrea, Eberle +4 more
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2011
Summary. CD95 expression on peripheral blood lymphocytes of 72 patients with chronic lymphocytic leukaemia (CLL) depending on the stage of disease, cytopenia pattern and the treatment schedules. A low (0???5%) level of CD95+ cells was detected in the majority (78%) of patients.
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Summary. CD95 expression on peripheral blood lymphocytes of 72 patients with chronic lymphocytic leukaemia (CLL) depending on the stage of disease, cytopenia pattern and the treatment schedules. A low (0???5%) level of CD95+ cells was detected in the majority (78%) of patients.
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CD95/Fas ligand induced toxicity
Biochemical Society Transactions, 2023The role of CD95/Fas ligand (CD95L/FasL) in the induction of CD95-mediated extrinsic apoptosis is well characterized. Trimerized, membrane-bound CD95L ligates the CD95 receptor activating downstream signaling resulting in the execution of cells by caspase proteins.
Ashley Haluck-Kangas, Marcus E. Peter
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CD95-Mediated Calcium Signaling
2017Intracellular calcium signals regulate cell function and cell survival by controlling many processes. CD95 engagement results in distinct intracellular calcium signals that control the cell fate, apoptosis, or survival, depending on the ligand (membrane or soluble).
Mehdi, Hammadi +4 more
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CD95/CD95 Ligand-Mediated Counterattack Does Not Block T Cell Cytotoxicity
Biochemical and Biophysical Research Communications, 2000Expression of CD95 ligand on parenchymal, epithelial, or tumor cells has been suggested to downregulate the immune response and to control lymphocyte activation. Suppression might be mediated by induction of apoptosis or by inhibition of Ca(2+) channels upon CD95 triggering.
A, Jekle +4 more
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CD95 signaling in colorectal cancer
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2012CD95 and its ligand (CD95L) are widely expressed in colorectal tumors, but their role in shaping tumor behavior is unclear. CD95 activation on tumor cells can lead to apoptosis, while CD95L attracts neutrophils, suggesting a function in tumor suppression.
Hoogwater, Frederik J. H. +4 more
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CD95-Mediated Proton Regulation
2017The Na+/H+ exchanger NHE1 is at the crossroads of a large diversity of signaling pathways, whose activation modifies the cooperative response of the transporter to intracellular H+ ions. Here we show how the activation of the Na+/H+ exchanger NHE1 by the cleaved ligand of CD95 can be measured.
Tauzin, Sébastien +9 more
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CD95 Signaling in Cancer Treatment
Current Pharmaceutical Design, 2014The CD95/CD95 ligand (CD95L) system regulates cell death, which plays a relevant role in cancer. The impairment of the CD95/CD95L system in cancer cells may lead to apoptosis resistance and contributes to tumor progression. However, a complete loss of CD95 is rarely seen in human cancers, and many cancer cells express large quantities of CD95 ...
Angel J, De la Rosa +4 more
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